{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:14:12Z","timestamp":1765476852092,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"6652","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1988,10,1]]},"abstract":"<jats:p>Transabdominal chorionic villus biopsy is an established method of obtaining material for analysing fetal chromosomes in the first trimester of pregnancy but has not been widely used for karyotyping in the second and third trimesters, when rapid results are required. The technique was evaluated in two groups of patients, comprising 106 at risk of having a fetus with chromosomal anomalies (105) or X linked disease (one) studied between 13 and 22 weeks (median 15 weeks) of gestation (group 1) and 21 with abnormal fetal findings on ultrasonography studied between 13 and 38 weeks (median 27 weeks) (group 2). Chorionic tissue was collected at the first attempt in 109 patients and at the second attempt in a further 17 independent of the position of the placenta. In one case from group 1 sufficient material for analysis could not be obtained. Seven abnormal karyotypes (six in group 1 and one in group 2) were diagnosed. Karyotyping was unsuccessful in two cases in group 1 (at 17 and 18 weeks' gestation) and in two in group 2 (at 29 and 38 weeks' gestation). Follow up of group 1 four weeks after sampling showed no signs of adverse fetal development apart from one unexplained intrauterine fetal death. The findings suggest that chorionic sampling is a safe and valuable additional technique for the late detection of chromosomal defects.<\/jats:p>","DOI":"10.1136\/bmj.297.6652.822","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"822-823","source":"Crossref","is-referenced-by-count":24,"title":["Transabdominal chorionic villus biopsy in second and third trimesters of pregnancy to determine fetal karyotype."],"prefix":"10.1136","volume":"297","author":[{"given":"L.","family":"Pijpers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Jahoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Reuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Wladimiroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/pd.1970040302","article-title":"Transabdominal fine needle biopsy from chorionic villi in the first trimester","volume":"4","author":"Smidt-Jensen, S.; Hahnemann, N.","year":"1984","unstructured":"Smidt-Jensen S, Hahnemann N. Transabdominal fine needle biopsy from chorionic villi in the first trimester. Prenat Diagn 1984;4:163-9.","journal-title":"Prenat Diagn"},{"key":"ref_2","first-page":"543","article-title":"Why confine chorionic villus (placental) biopsy to the first trimester?","volume":"i:","author":"Nicolaides, K.H.; Rodeck, C.H.; Soothill, P.W.; Warren, R.C.","year":"1986","unstructured":"Nicolaides KH, Rodeck CH, Soothill PW, Warren RC. Why confine chorionic villus (placental) biopsy to the first trimester? Lancet 1986;i:543-4.","journal-title":"Lancet"},{"key":"ref_3","first-page":"512","article-title":"Mid-trimester chorionic biopsy","volume":"93","author":"Szabo, J.; Gellen, J.; Szemere, G.","year":"1986","unstructured":"Szabo J, Gellen J, Szemere G. Mid-trimester chorionic biopsy. Br 7 Obstet Gynaecol 1986;93:512-3."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1056\/NEJM198710293171816","article-title":"Safety of placental biopsy in the second and third trimesters","volume":"317","author":"Holzgreve, W.; Miny, P.; Basaran, S.; Fuhrmann, W.; Belle, F.K.","year":"1987","unstructured":"Holzgreve W, Miny P, Basaran S, Fuhrmann W, Belle FK. Safety of placental biopsy in the second and third trimesters. N Engly Med 1987;317:1159.","journal-title":"N Engly Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF00274761","article-title":"Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancy","volume":"63","author":"Simoni, G.; Brambati, B.; Danesino, C.","year":"1983","unstructured":"Simoni G, Brambati B, Danesino C. Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancy. Hum Genet 1983;63:349-57.","journal-title":"Hum Genet"},{"key":"ref_6","first-page":"323","article-title":"A simple technique for obtaining high quality chromosome preparations from chorionic villus samples using FdU synchronisation","volume":"7","author":"Gibas, L.M.; Grujic, S.; Barr, M.A.; Jackson, L.G.","year":"1987","unstructured":"Gibas LM, Grujic S, Barr MA, Jackson LG. A simple technique for obtaining high quality chromosome preparations from chorionic villus samples using FdU synchronisation. PrenatDtagn 1987;7:323-7.","journal-title":"PrenatDtagn"},{"key":"ref_7","first-page":"895","article-title":"On intrauterine growth. The significance of prenatal care. Int7 Gynaecol","volume":"8","author":"Kloosterman, G.","year":"1970","unstructured":"Kloosterman G. On intrauterine growth. The significance of prenatal care. Int7 Gynaecol Obstet 1970;8:895-904.","journal-title":"Obstet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0002-9378(85)80254-4","article-title":"Fetal blood sampling during pregnancy with the use of a needle guided by ultrasound: a study of 606 consecutive cases","volume":"153","author":"Daffos, F.; Capella-Pavlovsky, M.; Forestier, F.","year":"1985","unstructured":"Daffos F, Capella-Pavlovsky M, Forestier F. Fetal blood sampling during pregnancy with the use of a needle guided by ultrasound: a study of 606 consecutive cases. AmJ Obstet Gynecol 1985;153:655-60.","journal-title":"AmJ Obstet Gynecol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(86)90824-X","article-title":"Rapid karyotyping in non-lethal fetal malformations","volume":"i:","author":"Nicolaides, K.H.; Rodeck, C.H.; Gosden, C.M.","year":"1986","unstructured":"Nicolaides KH, Rodeck CH, Gosden CM. Rapid karyotyping in non-lethal fetal malformations. Lancet 1986;i:283-6.","journal-title":"Lancet"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.297.6652.822","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.297.6652.822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:10:57Z","timestamp":1765476657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.297.6652.822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10,1]]},"references-count":9,"journal-issue":{"issue":"6652","published-online":{"date-parts":[[1988,10,1]]},"published-print":{"date-parts":[[1988,10,1]]}},"alternative-id":["10.1136\/bmj.297.6652.822"],"URL":"https:\/\/doi.org\/10.1136\/bmj.297.6652.822","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1988,10,1]]}}}