{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:58:29Z","timestamp":1776801509066,"version":"3.51.2"},"reference-count":4,"publisher":"BMJ","issue":"6655","license":[{"start":{"date-parts":[[1988,10,22]],"date-time":"1988-10-22T00:00:00Z","timestamp":593481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1988,10,22]]},"abstract":"<jats:p>With a systematically sampled population of children aged under 5 attending this centre for diarrhoeal disease research during 1983-5 a retrospective analysis of persistent diarrhoea (defined as greater than 14 days' duration) was performed to identify the possible risk factors for this syndrome. Of the 4155 children included in the analysis, 410 (10%) gave a history of persistent diarrhoea. A comparison with children with acute diarrhoea matched for age showed that 11 factors were correlated with persistent diarrhoea, and strongly associated factors were stools with blood or mucus, or both, lower respiratory tract infection, malnutrition, vitamin A deficiency, and antibiotic use before presentation. The peak age was 2 years, and there was no sex difference. Deaths occurred more often in the group with persistent diarrhoea. Although Shigella spp, Campylobacter jejuni, and Giardia lamblia were frequently identified, their rates of isolation were not significantly higher among patients with persistent diarrhoea. No seasonal variation was observed in the rates of persistent diarrhoea. Although the introduction of family food to the diet was associated with higher rates, this factor was difficult to separate from the age dependent risks.<\/jats:p>","DOI":"10.1136\/bmj.297.6655.1036","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1036-1038","source":"Crossref","is-referenced-by-count":28,"title":["Risk factors for persistent diarrhoea."],"prefix":"10.1136","volume":"297","author":[{"given":"N. S.","family":"Shahid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Sack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N.","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,10,22]]},"reference":[{"key":"ref_1","first-page":"124","article-title":"Chronic diarrhea","volume":"11","author":"Ament, M.E.; Barclay, G.N.","year":"1982","unstructured":"Ament ME, Barclay GN. Chronic diarrhea. PediatrAnn 1982;11:124-31.","journal-title":"PediatrAnn"},{"key":"ref_2","article-title":"Demographic surveillance system -Mat'ab. Vol 10. Vital events and migration-tables, 1980","volume-title":"61. (Scientific report No 58.) 3 Black RE, Lopez de Ramana","author":"Chowdhury, M.K.; Razzaque, A.; Mostafa, G.; Sarder, A.M.; D'souza, S.","year":"1982","unstructured":"Chowdhury MK, Razzaque A, Mostafa G, Sarder AM, D'souza S. Demographic surveillance system -Mat'ab. Vol 10. Vital events and migration-tables, 1980. Dhaka: International Centre for Diarrhoeal Disease Research, Bangladesh, 1982:61. (Scientific report No 58.) 3 Black RE, Lopez de Ramana G, Brown KH, et al. Development of nutritious hygienic weaning food to reduce diarrhea in Peru. Johns Hopkins University annual report. 1982-1983. Baltimore: Johns Hopkins, 1983."},{"key":"ref_3","first-page":"\"1","article-title":"Diarrhoeal diseases control programme. A manual for the treatment of acute diarrhoea","volume":"5","author":"Samadi, A.R.; Islam, M.R.; ICDDR, Aziz K.M.S.","year":"1980","unstructured":"World Health Organisation. Diarrhoeal diseases control programme. A manual for the treatment of acute diarrhoea. Geneva: WHO, 1980. (WHO\/CDD\/SER\/ 80.2.) 5 Samadi AR, Islam MR, Aziz KMS. ICDDR, B model for treatment ofdiarrhoeal diseases. Dhaka: International Centre for Diarrhoeal Disease Research, Bangladesh, 1982:1-12. (Special publication No 19.) 6 Stoll BJ, Glass RI, Huq MI, Khan MU, Holt JE, Banu H. Surveillance of patients attending a diarrhoeal disease hospital in Bangladesh. Br Med J 1982;285: 1185-8.","journal-title":"Br Med J; B model for treatment ofdiarrhoeal diseases"},{"key":"ref_4","article-title":"A guideline for the measurement of nutritional impact of supplementary feeding programmes aimed at vulnerable groups","author":"World Health Organisation","year":"1979","unstructured":"World Health Organisation. A guideline for the measurement of nutritional impact of supplementary feeding programmes aimed at vulnerable groups. Geneva: WHO, 1979. (FAP 79.1.)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.297.6655.1036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.297.6655.1036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:23:43Z","timestamp":1765477423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.297.6655.1036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10,22]]},"references-count":4,"journal-issue":{"issue":"6655","published-online":{"date-parts":[[1988,10,22]]},"published-print":{"date-parts":[[1988,10,22]]}},"alternative-id":["10.1136\/bmj.297.6655.1036"],"URL":"https:\/\/doi.org\/10.1136\/bmj.297.6655.1036","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10,22]]}}}