{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:33:47Z","timestamp":1780054427301,"version":"3.54.0"},"reference-count":16,"publisher":"BMJ","issue":"6659","license":[{"start":{"date-parts":[[1988,11,19]],"date-time":"1988-11-19T00:00:00Z","timestamp":595900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1988,11,19]]},"abstract":"<jats:p>A case-control study was performed to determine whether aspirin confers a similar risk of bleeding from gastric or duodenal ulcers in the elderly as non-aspirin, non-steroidal anti-inflammatory drugs. The intake of analgesics in 230 patients with bleeding ulcers aged 60 and over and in hospital and community controls matched for age and sex was examined. Those who had taken aspirin were between two and three times more likely to be admitted to hospital with bleeding ulcers. This increased risk was not accounted for by aspirin taken for indigestion or by concurrent use of non-aspirin, non-steroidal anti-inflammatory drugs. A similar effect was not seen for paracetamol. When aspirin and other non-steroidal anti-inflammatory drugs were considered together the overall risk attributed to the drugs suggested that these drugs may be responsible for over a third of admissions for bleeding peptic ulcers in the elderly.<\/jats:p>","DOI":"10.1136\/bmj.297.6659.1311","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1311-1313","source":"Crossref","is-referenced-by-count":88,"title":["Aspirin and bleeding peptic ulcers in the elderly."],"prefix":"10.1136","volume":"297","author":[{"given":"G.","family":"Faulkner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Prichard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Somerville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Langman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1988,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0140-6736(58)90423-9","article-title":"Gastrointestinal haemorrhage and salicyclates","volume":"ii:","author":"Alvarez, A.S.; Summerskill, W.H.J.","year":"1958","unstructured":"Alvarez AS, Summerskill WHJ. Gastrointestinal haemorrhage and salicyclates. Lancet 1958;ii:920-5.","journal-title":"Lancet"},{"key":"ref_2","first-page":"179","article-title":"smoking and other factors in the aetiology of peptic ulcer","volume":"u:","author":"Allibone, A.; Bronchitis, Flint F.J.; aspirin","year":"1958","unstructured":"Allibone A, Flint FJ. Bronchitis, aspirin, smoking and other factors in the aetiology of peptic ulcer. Lancet 1958;u: 179-82.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1136\/gut.23.4.340","volume":"23","author":"Coggon, D.; Langman, M.J.S.; Aspirin, Spiegelhalter D.; paracetamol; haematemesis; melaena","year":"1982","unstructured":"Coggon D, Langman MJS, Spiegelhalter D. Aspirin, paracetamol, and haematemesis and melaena. Gut 1982;23:340-4.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/gut.11.7.627","article-title":"Epidemiological evidence for the association of aspirin and acute gastrointestinal bleeding","volume":"11","author":"Langman, M.J.S.","year":"1970","unstructured":"Langman MJS. Epidemiological evidence for the association of aspirin and acute gastrointestinal bleeding. Gut 1970;11:627-34.","journal-title":"Gut"},{"key":"ref_5","first-page":"101","article-title":"Aspirin and gastrointestinal haemorrhage: a methodologic assessment..7 Chronic","volume":"38","author":"Belcon, M.C.; Rooney, P.J.; Tugwell, P.","year":"1985","unstructured":"Belcon MC, Rooney PJ, Tugwell P. Aspirin and gastrointestinal haemorrhage: a methodologic assessment..7 Chronic Dis 1985;38:101-1 1.","journal-title":"Dis"},{"key":"ref_6","first-page":"132","article-title":"Gastric ulcer, duodenal ulcer, and gastric carcinoma: a case-control study of certain social and environmental factors","volume":"1","author":"Gilles, M.; Skyring, A.","year":"1968","unstructured":"Gilles M, Skyring A. Gastric ulcer, duodenal ulcer, and gastric carcinoma: a case-control study of certain social and environmental factors. Medj Aust 1968;ii: 1 132-7.","journal-title":"Medj Aust"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/gut.17.5.378","article-title":"Aspirin in chronic gastric ulcer: an Australian experience","volume":"17","author":"Duggan, J.M.","year":"1976","unstructured":"Duggan JM. Aspirin in chronic gastric ulcer: an Australian experience. Gut 1976;17:378-84.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0016-5085(81)90001-9","article-title":"Analgesic ingestion and chronic peptic ulcer","volume":"80","author":"Piper, D.W.; McIntosh, J.H.; Ariotti, D.E.; Fenton, B.H.; MacLennan, R.","year":"1981","unstructured":"Piper DW, McIntosh JH, Ariotti DE, Fenton BH, MacLennan R. Analgesic ingestion and chronic peptic ulcer. Gastroenterology 1981;80:427-32.","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/gut.26.8.789","article-title":"Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms","volume":"26","author":"McIntosh, J.H.; Byth, K.; Piper, D.W.","year":"1985","unstructured":"McIntosh JH, Byth K, Piper DW. Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms. Gut 1985;26:789-98.","journal-title":"Gut"},{"key":"ref_10","article-title":"Statistical methods in cancer research. Vol 1. The analysis ofcase-control studies","author":"Breslow, N.E.; Day, N.E.","year":"1980","unstructured":"Breslow NE, Day NE. Statistical methods in cancer research. Vol 1. The analysis ofcase-control studies. Lyons: International Agency for Research on Cancer, 1980."},{"key":"ref_11","first-page":"56","article-title":"Statistical methods for rates and proportions","author":"Fleiss, J.L.","year":"1981","unstructured":"Fleiss JL. Statistical methods for rates and proportions. 2nd ed. New York: Wiley, 1981:56-82.","edition":"2nd ed"},{"key":"ref_12","volume-title":"A dictionary of epidemiology","author":"Last, J.M.","year":"1983","unstructured":"Last JM, ed. A dictionary of epidemiology. Oxford: Oxford University Press, 1983."},{"key":"ref_13","first-page":"489","article-title":"Rising frequency of ulcer perforation in elderly people in the United Kingdom","volume":"i:","author":"Walt, R.; Katschinski, B.; Logan, R.; Ashley, J.; Langman, M.","year":"1986","unstructured":"Walt R, Katschinski B, Logan R, Ashley J, Langman M. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1986;i: 489-92.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/BF01324896","article-title":"The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers. A gastroscopic and photographic study","volume":"24","author":"Lanza, F.L.; Royer, JR, Nelson; RS, Chen; TT, Seckman; CE, Rack; M.F.","year":"1979","unstructured":"Lanza FL, Royer JR, Nelson RS, Chen TT, Seckman CE, Rack MF. The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers. A gastroscopic and photographic study. Dig Dis Sci 1979;24:823-8.","journal-title":"Dig Dis Sci"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1136\/gut.23.8.692","article-title":"The effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa","volume":"23","author":"Hoftiezer, J.W.; O'Laughlin, J.L.; Ivey, K.J.","year":"1982","unstructured":"Hoftiezer JW, O'Laughlin JL, Ivey KJ. The effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa. Gut 1982;23:692-7.","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1056\/NEJM197405232902102","article-title":"Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease","volume":"290","author":"Levy, M.","year":"1974","unstructured":"Levy M. Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. N Englj Med 1974;290: 1158-62.","journal-title":"N Englj Med"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.297.6659.1311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.297.6659.1311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:44:37Z","timestamp":1765478677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.297.6659.1311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11,19]]},"references-count":16,"journal-issue":{"issue":"6659","published-online":{"date-parts":[[1988,11,19]]},"published-print":{"date-parts":[[1988,11,19]]}},"alternative-id":["10.1136\/bmj.297.6659.1311"],"URL":"https:\/\/doi.org\/10.1136\/bmj.297.6659.1311","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11,19]]}}}