{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:38:08Z","timestamp":1766428688820,"version":"3.48.0"},"reference-count":8,"publisher":"BMJ","issue":"6663","license":[{"start":{"date-parts":[[1988,12,17]],"date-time":"1988-12-17T00:00:00Z","timestamp":598320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1988,12,17]]},"abstract":"<jats:p>A national survey was conducted of patients with cystic fibrosis who were known to paediatricians, chest physicians, and others or whose deaths were reported through the death certification authorities in the United Kingdom during 1977 to 1985. From this population based study a revised incidence figure of one affected baby in 2500 live births was produced. Mortality was very high in the first year of life (7.6%) and was substantially greater for females than for males under age 20 years. A temporal improvement in mortality was found during the period under study, with about 100 more births than deaths occurring each year. This improvement was notable in the first five years of life. Meconium ileus, which used to be a primary cause of early mortality, is becoming increasingly rare as a cause of death. The total prevalence of cystic fibrosis in the UK in mid-1985 was estimated to be about 5000.<\/jats:p>","DOI":"10.1136\/bmj.297.6663.1599","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1599-1602","source":"Crossref","is-referenced-by-count":69,"title":["Cystic fibrosis in the United Kingdom 1977-85: an improving picture. British Paediatric Association Working Party on Cystic Fibrosis."],"prefix":"10.1136","volume":"297","member":"239","published-online":{"date-parts":[[1988,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/adc.59.1.71","article-title":"Cystic fibrosis mortality in England and Wales and in Victoria, Australia 1976-80","volume":"59","author":"Phelan, P.; Hey, E.","year":"1984","unstructured":"Phelan P, Hey E. Cystic fibrosis mortality in England and Wales and in Victoria, Australia 1976-80. Arch Dis Child 1984;59:71-3.","journal-title":"Arch Dis Child"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0895-4356(88)90063-7","article-title":"A comparison of survival, growth, and pulmonary function in patients with cystic fibrosis in","volume":"41","author":"Corey, M.; McLaughlin, F.J.; Williams, M.; Levison, H.","year":"1988","unstructured":"Corey M, McLaughlin FJ, Williams M, Levison H. 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Arch Dis Child 1971;46:139-43.","journal-title":"Arch Dis Child"},{"key":"ref_5","article-title":"A short textbook of medical statistics","author":"Hill, A.B.","year":"1980","unstructured":"Hill AB. A short textbook of medical statistics. London: Hodder and Stoughton, 1980:199-213."},{"key":"ref_6","first-page":"650","article-title":"Playing with fire: an experiment in clinical budgeting","volume":"290","author":"Lamb, S.M.; David, T.J.","year":"1985","unstructured":"Lamb SM, David TJ. Playing with fire: an experiment in clinical budgeting. BrMedJ 1985;290:650-1.","journal-title":"BrMedJ"},{"key":"ref_7","first-page":"1","article-title":"Cysticfibrosis","author":"Capewell, G.","year":"1986","unstructured":"Capewell G. Cysticfibrosis. London: Office of Health Economics, 1986:1-41."},{"key":"ref_8","article-title":"Support hosiery","volume-title":"GP","author":"Chilvers, A.","year":"1988","unstructured":"Chilvers A. Support hosiery. GP 1988 April 1."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.297.6663.1599","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.297.6663.1599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:06:28Z","timestamp":1765479988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.297.6663.1599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12,17]]},"references-count":8,"journal-issue":{"issue":"6663","published-online":{"date-parts":[[1988,12,17]]},"published-print":{"date-parts":[[1988,12,17]]}},"alternative-id":["10.1136\/bmj.297.6663.1599"],"URL":"https:\/\/doi.org\/10.1136\/bmj.297.6663.1599","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1988,12,17]]}}}