{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:29:54Z","timestamp":1766428194476,"version":"3.46.0"},"reference-count":18,"publisher":"BMJ","issue":"6674","license":[{"start":{"date-parts":[[1989,3,11]],"date-time":"1989-03-11T00:00:00Z","timestamp":605577600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1989,3,11]]},"abstract":"<jats:p>To assess the usefulness of continuous wave Doppler ultrasonography as an antenatal screening tool for the detection of intrauterine growth retardation and fetal compromise 2097 singleton pregnancies were studied. Umbilical artery velocity waveforms were obtained at 28, 34, and 38 weeks of gestation, from which the pulsatility index, A\/B ratio, and resistance parameter were calculated. No abnormal features or indices of neonatal outcome were adequately predicted. The most sensitive index for being delivered of a growth retarded infant (less than 5th centile birth weight for gestation) was an A\/B ratio at 34 weeks (sensitivity 40%, specificity 84%). Other measures that show poor neonatal nutritional state (ponderal index, skinfold thickness, and ratio of mid-arm circumference to head circumference) were even less well predicted. Acute and chronic hypoxia as determined by Apgar score, pH in blood from the cord artery, and packed cell volume correlated poorly with umbilical artery waveform indices, and there was no obvious difference between the indices of those who subsequently required operative or instrumental delivery for fetal distress and those requiring no intervention. There were three unexplained stillbirths in the series, in each of which the fetus had shown waveform patterns that suggested increased peripheral resistance, though the technique did not appear to be useful for predicting the time of subsequent death. Screening for small for dates babies in a three stage programme was of no value regardless of the threshold or index chosen. Obstetricians should resist the temptation to introduce screening with Doppler ultrasonography until its proper role has been determined.<\/jats:p>","DOI":"10.1136\/bmj.298.6674.631","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"631-635","source":"Crossref","is-referenced-by-count":90,"title":["Antenatal screening for intrauterine growth retardation with umbilical artery Doppler ultrasonography."],"prefix":"10.1136","volume":"298","author":[{"given":"R. B.","family":"Beattie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Dornan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,3,11]]},"reference":[{"key":"ref_1","first-page":"415","article-title":"Intrauterine growth retardation: prediction of perinatal distress by Doppler uiltrasound","volume":"ii:","author":"Rcuwer, P.J.H.M.; hA, Sijmons; Rietman, G.W.; Van Tiel, M.W.A.M.; Bruinsc, H.W.","year":"1987","unstructured":"Rcuwer PJHM, Sijmons hA, Rietman GW, Van Tiel MWAM, Bruinsc HW. Intrauterine growth retardation: prediction of perinatal distress by Doppler uiltrasound. Larcet 1987;ii:415-8.","journal-title":"Larcet"},{"key":"ref_2","first-page":"266","article-title":"Cotitinuous wave ultrasound as an alternative and complemcnt to x-rays in vascular examinations","volume-title":"Cardiovascular applications of ultrasound","author":"Gosling, R.G.; King, D.H.","year":"1974","unstructured":"Gosling RG, King DH. Cotitinuous wave ultrasound as an alternative and complemcnt to x-rays in vascular examinations. In: Reneman RS, ed. Cardiovascular applications of ultrasound. New York: Elsevier North Holland, 1974:266."},{"key":"ref_3","first-page":"73","article-title":"Extraction of physiological information from spectrum analysed Doppler-shiftcd contintiotis vavc uiltrasouind signal obtained non-invasivclv from the arterial tree","volume-title":"medical electronic mionogTraph 21","author":"Gosling, R.G.","year":"1976","unstructured":"Gosling RG. Extraction of physiological information from spectrum analysed Doppler-shiftcd contintiotis vavc uiltrasouind signal obtained non-invasivclv from the arterial tree. In: Hill DM, WVatson BW, eds. IFE medical electronic mionogTraph 21. Stcvenage: Peter lPeregrinus, 1976:73-125."},{"key":"ref_4","first-page":"213","article-title":"Applications cliniques de lexamen Doppler transcutane","volume-title":"I'elocimetric ultrasonore Doppler","author":"Pourcelot, L.","year":"1975","unstructured":"Pourcelot L. Applications cliniques de lexamen Doppler transcutane. In: Peroneau P, ed. I'elocimetric ultrasonore Doppler. Paris: INSERM, 1975: 213-40."},{"key":"ref_5","first-page":"3","article-title":"A comparative study cof three indiccs of umbilical blood flow in relation to prediction of growth retardation. P1'-rinat Med","volume":"15","author":"Mulders, L.G.M.; W'ijn, P.F.F.; Jongsma, H.W.; I'R, Hein","year":"1987","unstructured":"Mulders LGM, W'ijn PFF, Jongsma HW, Hein I'R. A comparative study cof three indiccs of umbilical blood flow in relation to prediction of growth retardation. P1'-rinat Med 1987;15:3-12."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1542\/peds.47.5.831","article-title":"Incidence of hypoglycemia in newborn infants classified by birthweight and gestational age","volume":"47","author":"l O, Lubchenco; H, Bard","year":"1971","unstructured":"Lubchenco l O, Bard H. Incidence of hypoglycemia in newborn infants classified by birthweight and gestational age. Pediatrics 1971;47:831.","journal-title":"Pediatrics"},{"key":"ref_7","first-page":"311","article-title":"Mid-arm circumference and midarm circumference\/head circtimference ratios: standard curves for anthropometric assessment of neonatal nutritional status","volume":"109","author":"Sasanow, SR, Georgieff; MK, Pereira; G.R.","year":"1986","unstructured":"Sasanow SR, Georgieff MK, Pereira GR. Mid-arm circumference and midarm circumference\/head circtimference ratios: standard curves for anthropometric assessment of neonatal nutritional status. 7 Pediatr 1986;109: 311-5."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0140-6736(87)91460-7","article-title":"Intrauterine growth retardation: prediction of perinatal distress by Doppler ultrasound","volume":"ii:","author":"Beattie, R.B.; Dornan, J.C.; Thompson, W.","year":"1987","unstructured":"Beattie RB, Dornan JC, Thompson W. Intrauterine growth retardation: prediction of perinatal distress by Doppler ultrasound. Lancet 1987;ii:974-5.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1471-0528.1980.tb04613.x","article-title":"Fetal blood selocitV waveforms in normal pregnancy","volume":"87","author":"Stuart, B.; D., umm J.; I), Fitzgerald; Duignan, N.M.S.","year":"1980","unstructured":"Stuart B, D.:umm J, Fitzgerald I), Duignan NMS. Fetal blood selocitV waveforms in normal pregnancy. BrJ Obstet Gvnaecol 1980;87:780-5.","journal-title":"BrJ Obstet Gvnaecol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0095-5108(18)30836-4","article-title":"Assessment of fetal growth","volume":"13","author":"Lockwood, C.I.; Weiner, S.","year":"1986","unstructured":"Lockwood CI, Weiner S. Assessment of fetal growth. Clin Perinatol 1986;13: 3-35.","journal-title":"Clin Perinatol"},{"key":"ref_11","first-page":"5112","article-title":"Umbilical arterv velocitv waveform and intrauterine growth retardation","volume":"151","author":"Fleischer, A.; Schtilman, H.; Farmakides, G.","year":"1985","unstructured":"Fleischer A, Schtilman H, Farmakides G, et al. Umbilical arterv velocitv waveform and intrauterine growth retardation. 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Am] ObstetQvneuscol 1987:157:774-9.","journal-title":"Am] ObstetQvneuscol"},{"key":"ref_18","first-page":"929","article-title":"D)oppler ultrasound. Br O)bstet Gvnacecsl","volume":"94","author":"Neilson, J.P.","year":"1987","unstructured":"Neilson JP. D)oppler ultrasound. Br O)bstet Gvnacecsl 1987;94:929-34."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.298.6674.631","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.298.6674.631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:28:51Z","timestamp":1765261731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.298.6674.631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3,11]]},"references-count":18,"journal-issue":{"issue":"6674","published-online":{"date-parts":[[1989,3,11]]},"published-print":{"date-parts":[[1989,3,11]]}},"alternative-id":["10.1136\/bmj.298.6674.631"],"URL":"https:\/\/doi.org\/10.1136\/bmj.298.6674.631","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1989,3,11]]}}}