{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:13:49Z","timestamp":1767651229734,"version":"3.46.0"},"reference-count":10,"publisher":"BMJ","issue":"6685","license":[{"start":{"date-parts":[[1989,5,27]],"date-time":"1989-05-27T00:00:00Z","timestamp":612230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1989,5,27]]},"abstract":"<jats:p>OBJECTIVE--To assess the morbidity and mortality associated with a prenatal diagnosis of bilateral fetal uropathy. DESIGN--Retrospective study. SETTING--Departments of radiology, paediatric surgery, obstetrics, and pathology in two teaching hospitals that serve as referral centres for the Yorkshire region. PATIENTS--126 Cases of fetal uropathy were referred either prenatally or postnatally from hospitals in Yorkshire between August 1982 and December 1987. The disease was bilateral in 54 cases and unilateral in 72 cases. In 14 cases bilateral fetal uropathy was associated with coexistent disease. INTERVENTIONS--All cases were managed individually by an obstetrician after discussion with the radiologists and paediatric surgeons. Babies who survived were treated prophylactically with antibiotics after delivery and were operated on if appropriate. END POINT--Assessment of prognosis for long term renal function for each baby referred between August 1982 and December 1987: follow up ranged from six months to five years. MEASUREMENTS AND MAIN RESULTS--Of the 54 fetuses with bilateral fetal uropathy, 13 were terminated as the prenatal findings of ultrasonography were considered to be incompatible with long term survival. Ten of the liveborn babies died, five of renal or pulmonary insufficiency, or both, and five of associated congenital anomalies. Thirty one infants survived to follow up; four of these had serious coexistent disease and two had impaired renal function. Thus the overall mortality was 43% and the morbidity rate 19%. The renal anomaly was associated with other serious disease in 14 cases (26%) compared with two (3%) of the 72 cases of unilateral fetal uropathy. All but two of the 27 infants with isolated bilateral urinary tract disease had excellent prospects for survival. CONCLUSION--Although bilateral fetal uropathy is associated with a high morbidity rate and mortality, careful prenatal assessment can help to identify fetuses with a poor prognosis. The outlook for a fetus with isolated renal disease if treated promptly after delivery is excellent and compares favourably with that reported after prenatal surgical intervention.<\/jats:p>","DOI":"10.1136\/bmj.298.6685.1419","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1419-1420","source":"Crossref","is-referenced-by-count":12,"title":["Bilateral fetal uropathy: what is the outlook?"],"prefix":"10.1136","volume":"298","author":[{"given":"R. J.","family":"Arthur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C.","family":"Irving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K.","family":"Watters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,5,27]]},"reference":[{"key":"ref_1","first-page":"784","article-title":"Prenatal diagnosis: how useful is it?","volume":"57","author":"Thomas, D.F.; Irving, H.C.; Arthur, R.J.","year":"1985","unstructured":"Thomas DF, Irving HC, Arthur RJ. Prenatal diagnosis: how useful is it? BrJ7 Urol 1985;57:784-7."},{"key":"ref_2","article-title":"Dialogues in pediatric urology: fetal intervention for obstructive uropathy","author":"Duckett, J.W.","year":"1982","unstructured":"Duckett JW. Dialogues in pediatric urology: fetal intervention for obstructive uropathy. New York: William J Miller Associates, 1982."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0031-3955(16)36336-2","article-title":"Antenatal diagnosis and management of urinary anomalies","volume":"34","author":"Colodny, A.H.","year":"1987","unstructured":"Colodny AH. Antenatal diagnosis and management of urinary anomalies. PediatrClin North Am 1987;34:1365-81.","journal-title":"PediatrClin North Am"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0031-3955(16)36259-9","article-title":"The dilemma of intrauterine diagnosis of congenital renal disease","volume":"34","author":"Grupe, W.E.","year":"1987","unstructured":"Grupe WE. The dilemma of intrauterine diagnosis of congenital renal disease. Pediatr Clin North Am 1987;34:629-38.","journal-title":"Pediatr Clin North Am"},{"key":"ref_5","first-page":"556","article-title":"Fetal hydronephrosis: selection and surgical repair","volume":"22","author":"Harrison, M.R.; Golbus, M.S.; Filly, R.A.","year":"1987","unstructured":"Harrison MR, Golbus MS, Filly RA, et al. Fetal hydronephrosis: selection and surgical repair..JPediatrSurg 1987;22:556-8.","journal-title":"JPediatrSurg"},{"key":"ref_6","first-page":"376","article-title":"Management of the fetus with congenital hydronephrosis. Prognostic criteria and selection for treatment","volume":"20","author":"Glick, P.L.; Harrison, M.R.; Golbus, M.S.","year":"1985","unstructured":"Glick PL, Harrison MR, Golbus MS, et al. Management of the fetus with congenital hydronephrosis. Prognostic criteria and selection for treatment. J PediatrSurg 1985;20:376-87.","journal-title":"J PediatrSurg"},{"key":"ref_7","first-page":"1007","article-title":"Intervention for fetal obstructive uropathy: has it been effective?","volume":"ii:","author":"Elder, J.S.; Duckett, J.W.; Snyder, H.M.","year":"1987","unstructured":"Elder JS, Duckett JW, Snyder HM. Intervention for fetal obstructive uropathy: has it been effective? Lancet 1987;ii: 1007-9.","journal-title":"Lancet"},{"key":"ref_8","first-page":"336","article-title":"Report of the Intemational Fetal Surgery Registry","volume":"315","author":"Manning, F.A.; Harrison, M.R.; Rodeck, C.","year":"1986","unstructured":"Manning FA, Harrison MR, Rodeck C, et al. Report of the Intemational Fetal Surgery Registry. N EnglJ Med 1986;315:336-40.","journal-title":"N EnglJ Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1464-410X.1988.tb04351.x","article-title":"Antenatal diagnosis of congenital abnormalities in the urinary tract. Results from the Northern region fetal anomaly survey","volume":"62","author":"Scott, J.E.S.; Renwick, M.","year":"1988","unstructured":"Scott JES, Renwick M. Antenatal diagnosis of congenital abnormalities in the urinary tract. Results from the Northern region fetal anomaly survey. BrJ Urol 1988;62:295-300.","journal-title":"BrJ Urol"},{"key":"ref_10","first-page":"1026","article-title":"Caution in antenatal intervention","volume":"139","author":"Sholder, A.J.; Maizels, M.; Depp, R.","year":"1988","unstructured":"Sholder AJ, Maizels M, Depp R, et al. Caution in antenatal intervention. 7 Urol 1988;139:1026-9."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.298.6685.1419","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.298.6685.1419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:08:46Z","timestamp":1765264126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.298.6685.1419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5,27]]},"references-count":10,"journal-issue":{"issue":"6685","published-online":{"date-parts":[[1989,5,27]]},"published-print":{"date-parts":[[1989,5,27]]}},"alternative-id":["10.1136\/bmj.298.6685.1419"],"URL":"https:\/\/doi.org\/10.1136\/bmj.298.6685.1419","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1989,5,27]]}}}