{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:27:13Z","timestamp":1765265233665,"version":"3.46.0"},"reference-count":10,"publisher":"BMJ","issue":"6689","license":[{"start":{"date-parts":[[1989,6,24]],"date-time":"1989-06-24T00:00:00Z","timestamp":614649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1989,6,24]]},"abstract":"<jats:p>OBJECTIVE--To define the concentrations of inhibin in serum and tissue of patients with hydatidiform mole and assess their value as a clinical marker of the condition. DESIGN--Prospective study of new patients with hydatidiform mole, comparison of paired observations, and case-control analysis. SETTING--A university hospital, two large public hospitals, and a private women's clinic in Japan. PATIENTS--Seven consecutive referred patients seen over four months with newly diagnosed complete hydatidiform mole, including one in whom the mole was accompanied by viable twin fetuses (case excluded from statistical analysis because of unique clinical features). All patients followed up for six months after evacuation of molar tissue. END POINT--Correlation of serum inhibin concentrations with trophoblastic disease. MEASUREMENTS AND MAIN RESULTS--Serum concentrations of inhibin, human chorionic gonadotrophin, and follicle stimulating hormone were compared before and seven to 10 days after evacuation of the mole. Before evacuation the serum inhibin concentrations (median 8.3 U\/ml; 95% confidence interval 2.4 to 34.5) were significantly greater than in 21 normal women at the same stage of pregnancy (2.8 U\/ml; 2.1 to 3.6), and inhibin in molar tissue was also present in high concentrations (578 U\/ml cytosol; 158 to 1162). Seven to 10 days after evacuation inhibin concentrations in serum samples from the same patients declined significantly to values (0.4 U\/ml; 0.1 to 1.4) similar to those seen in the follicular phase of normal menstrual cycles. None of the four patients whose serum inhibin concentrations were 0.4 U\/ml or less after evacuation developed persistent trophoblastic disease. Though serum human chorionic gonadotrophin concentrations declined after evacuation (6.6 x 10(3) IU\/l; 0.8 x 10(3) to 32.6 x 10(3], they remained far higher than in non-pregnant women. Serum follicle stimulating hormone concentrations remained suppressed. CONCLUSIONS--In this small study serum inhibin concentrations higher than those found in the early follicular phase one to two weeks after evacuation of a hydatidiform mole seemed to be specific for persistent trophoblastic disease. Further data are needed to confirm these promising results.<\/jats:p>","DOI":"10.1136\/bmj.298.6689.1684","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1684-1686","source":"Crossref","is-referenced-by-count":37,"title":["Inhibin: a new circulating marker of hydatidiform mole?"],"prefix":"10.1136","volume":"298","author":[{"given":"T.","family":"Yohkaichiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Fukaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hoshiai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"de Kretser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-291X(86)90758-8","article-title":"The human placenta: a novel source of inhibin","volume":"140","author":"McLachlan, R.I.; Healv, D.L.; Robertson, D.M.; Burger, H.G.; de Kretser, D.M.","year":"1986","unstructured":"McLachlan RI, Healv DL, Robertson DM, Burger HG, de Kretser DM. The human placenta: a novel source of inhibin. Biochem Biophys Res Commun 1986;140:485-90.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0015-0282(16)59599-5","article-title":"Circulating immunoactive inhibin in the luteal phase and early gestation of women undergoing ovulation induction","volume":"48","author":"McLachlan, R.I.; Healy, D.L.; Robertson, D.M.; Burger, H.G.; de Kretser, D.M.","year":"1987","unstructured":"McLachlan RI, Healy DL, Robertson DM, Burger HG, de Kretser DM. Circulating immunoactive inhibin in the luteal phase and early gestation of women undergoing ovulation induction. Fertil Steril 1987;48:1001-5.","journal-title":"Fertil Steril"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1126\/science.3299703","article-title":"Localisation, secretion and action of inhibin in human placenta","volume":"237","author":"Petraglia, F.; Sawchenko, P.; Lim, A.T.W.; Rivier, J.; Vale, W.","year":"1987","unstructured":"Petraglia F, Sawchenko P, Lim ATW, Rivier J, Vale W. Localisation, secretion and action of inhibin in human placenta. Science 1987;237:187-9.","journal-title":"Science"},{"key":"ref_4","first-page":"5849","article-title":"Inhibin A-subunit cD)NAs from porcinec ovary","volume-title":"and human placenta. Proc Natl Acad Sci USA","volume":"83","author":"Mayo, K.E.; Cerelli, G.M.; Spiess, J.; el al","year":"1986","unstructured":"Mayo KE, Cerelli GM, Spiess J, el al. Inhibin A-subunit cD)NAs from porcinec ovary and human placenta. Proc Natl Acad Sci USA 1986;83:5849-53."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1210\/jcem-65-5-954","article-title":"Circulating immunoreactive inhibin levels during the normal human menstrual cycle","volume":"65","author":"McLachlan, R.I.; Robertson, D.M.; Healy, D.L.; Burger, H.G.; de Kretser, D.M.","year":"1987","unstructured":"McLachlan RI, Robertson DM, Healy DL, Burger HG, de Kretser DM. Circulating immunoreactive inhibin levels during the normal human menstrual cycle. J Clin Endocrinol Metab 1987;65:954-61.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1210\/jcem-67-3-438","article-title":"Comparison of inhibin immunological and in vitro biological activities in human serum","volume":"67","author":"Robertson, DM\\,; CG, Tsonis; RI, McLachlan","year":"1988","unstructured":"Robertson DM\\, Tsonis CG, McLachlan RI, et al. Comparison of inhibin immunological and in vitro biological activities in human serum. J Clin Endocrinol Metab 1988;67:438-43.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1471-0528.1958.tb09193.x","article-title":"Further observations on the excretion of chorionic gonadotrophin by women with hvdatidiform mole","volume":"65","author":"Hobson, B.M.","year":"1958","unstructured":"Hobson BM. Further observations on the excretion of chorionic gonadotrophin by women with hvdatidiform mole. Br J Obstet Gynaecol 1958;65: 253-9.","journal-title":"Br J Obstet Gynaecol"},{"key":"ref_8","first-page":"137","article-title":"HCG in pathologic pregnancy. Eurj Obstet Gynecol Reprod Biol","volume":"3","author":"van Leusden HA","year":"1973","unstructured":"van Leusden HA. HCG in pathologic pregnancy. Eurj Obstet Gynecol Reprod Biol 1973;3:137-46."},{"key":"ref_9","first-page":"390","article-title":"Metastatic gestational trophoblastic disease: experience at the New England Trophoblastic Disease","volume":"69","author":"DuBeshter, B.; Berkowitz, R.S.; Goldstein, D.P.; Cramer, D.W.; Berstein, M.R.","year":"1965","unstructured":"DuBeshter B, Berkowitz RS, Goldstein DP, Cramer DW, Berstein MR. Metastatic gestational trophoblastic disease: experience at the New England Trophoblastic Disease Center, 1965 to 1985. Obstet Gynecol 1987;69:390-5.","journal-title":"Center"},{"key":"ref_10","first-page":"478","article-title":"Prognostic characteristics of serum human chorionic gonadotrophin titer regression following molar pregnancy","volume":"58","author":"Schlaerth, J.B.; Morrow, C.P.; Kletzky, O.A.; Nalick, R.H.; D'Ablaing, G.A.","year":"1981","unstructured":"Schlaerth JB, Morrow CP, Kletzky OA, Nalick RH, D'Ablaing GA. Prognostic characteristics of serum human chorionic gonadotrophin titer regression following molar pregnancy. Obstet Gynecol 1981;58:478-82.","journal-title":"Obstet Gynecol"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.298.6689.1684","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.298.6689.1684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:23:12Z","timestamp":1765264992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.298.6689.1684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6,24]]},"references-count":10,"journal-issue":{"issue":"6689","published-online":{"date-parts":[[1989,6,24]]},"published-print":{"date-parts":[[1989,6,24]]}},"alternative-id":["10.1136\/bmj.298.6689.1684"],"URL":"https:\/\/doi.org\/10.1136\/bmj.298.6689.1684","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1989,6,24]]}}}