{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:02:38Z","timestamp":1787241758528,"version":"build-2736575974"},"reference-count":23,"publisher":"BMJ","issue":"6691","license":[{"start":{"date-parts":[[1989,7,8]],"date-time":"1989-07-08T00:00:00Z","timestamp":615859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1989,7,8]]},"abstract":"<jats:p>OBJECTIVE--To see whether children who have had chemotherapy develop increased numbers of moles. DESIGN--Blind assessment of patients having chemotherapy and subsequent comparison with the first suitable patients matched for age and sex who were attending the clinic during the same period after having completed treatment. Controls were obtained the following year by taking the first suitable patients attending a routine dermatology outpatient clinic who matched the study groups for age and sex. SETTING--Referrals to a paediatric oncology clinic and a dermatology clinic at two city hospitals. PATIENTS--The group receiving chemotherapy comprised all 32 patients with acute lymphatic leukaemia, lymphoma, and rhabdomyosarcoma who were attending the paediatric oncology clinic on two mornings a week during October 1987 to March 1988. The group who had completed treatment comprised 32 patients who were attending for follow up during the same period and who matched the first group for age and sex. Thirty two other patients attending the dermatology outpatient clinic with unrelated skin conditions served as controls. END POINT--Definite increase in numbers of moles on children after a course of chemotherapy. MEASUREMENTS AND MAIN RESULTS--Moles were counted by one observer on defined areas of the body and divided into those less than 3 mm and greater than or equal to 3 mm diameter. Patients receiving chemotherapy had a similar number of moles to the control group. By contrast patients who had completed chemotherapy had significant increases both in moles less than 3 mm and greater than or equal to 3 mm and in the total number of moles. These patients were more likely to have moles on acral sites. CONCLUSIONS--Children with substantially increased numbers of moles (benign melanocytic naevi) after successful chemotherapy for malignancy may have an increased risk of melanoma. They should be offered prolonged surveillance and cautioned about exposure to ultraviolet light.<\/jats:p>","DOI":"10.1136\/bmj.299.6691.88","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"88-91","source":"Crossref","is-referenced-by-count":73,"title":["Excess benign melanocytic naevi after chemotherapy for malignancy in childhood."],"prefix":"10.1136","volume":"299","author":[{"given":"B. R.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Cunliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1989,7,8]]},"reference":[{"key":"ref_1","first-page":"1461","article-title":"Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive tion. We are adding to these preliminary data by studying a cohort of sibs. The significant difference between those patients drugs","volume":"ii:","author":"Kinlen, L.J.; Sheil, A.G.R.; Peto, J.; Doll, R.","year":"1979","unstructured":"Kinlen LJ, Sheil AGR, Peto J, Doll R. Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive tion. We are adding to these preliminary data by studying a cohort of sibs. The significant difference between those patients drugs. BrMedJ 1979;ii:1461-6.","journal-title":"BrMedJ"},{"key":"ref_2","first-page":"123","article-title":"Eruptive dysplastic naevi following renal transplantation. Clin Exp Dermatol","volume":"13","author":"Barker, J.N.W.N.; MlacDonald, D.M.","year":"1988","unstructured":"Barker JNWN, MlacDonald DM\\. Eruptive dysplastic naevi following renal transplantation. Clin Exp Dermatol 1988;13:123-5."},{"key":"ref_3","first-page":"862","article-title":"Regional distribution ot moles and still having treatment and those whose treatment was completed suggests that this effect is likely to be due to melanoma","volume":"65","author":"Pack, G.T.; Lenson, N.; Gerber, D.M.","year":"1952","unstructured":"Pack GT, Lenson N, Gerber DM. Regional distribution ot moles and still having treatment and those whose treatment was completed suggests that this effect is likely to be due to melanoma. Arch Surg 1952;65:862-70.","journal-title":"Arch Surg"},{"key":"ref_4","first-page":"191","article-title":"Development and elimination of pigmented moles, and the anatomical distribution of primary malignant melanoma. Cancer 1973; immunosuppression as a result of treatment rather than the underlying disease. Certain drugs included in the cytotoxic regimens of these patients (cyclophosphamide, doxorubicin, and daunorubicin) are known to cause generalised hyperpigmentation, but","author":"Nicholls, E.M.","unstructured":"Nicholls EM. Development and elimination of pigmented moles, and the anatomical distribution of primary malignant melanoma. Cancer 1973; immunosuppression as a result of treatment rather than the underlying disease. Certain drugs included in the cytotoxic regimens of these patients (cyclophosphamide, doxorubicin, and daunorubicin) are known to cause generalised hyperpigmentation, but to date there 32:191-5."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/jech.39.1.48","article-title":"Frequency of moles in a defined population","volume":"39","author":"Cooke, K.R.; Spears, G.F.S.; Skegg, D.C.G.","year":"1985","unstructured":"Cooke KR, Spears GFS, Skegg DCG. Frequency of moles in a defined population. J Epidemiol Community Health 1985;39:48-52.","journal-title":"J Epidemiol Community Health"},{"key":"ref_6","first-page":"167","article-title":"The number and distribution of benign pigmented moles (melanocytic naevi) in a healthy British population","volume":"113","author":"MacKie, R.M.; English, J.; Aitchison, T.C.; Fitzsimmons, C.P.; Wilson, P.D.","year":"1985","unstructured":"MacKie RM, English J, Aitchison TC, Fitzsimmons CP, Wilson PD. The number and distribution of benign pigmented moles (melanocytic naevi) in a healthy British population. BrJ7 Dermatol 1985;113:167-74."},{"key":"ref_7","first-page":"719","article-title":"The relation of race and complexion to the are no reports of these drugs giving rise to increased numbers of benign melanocytic naevi. incidence of moles and melanomas","volume":"100","author":"Pack, G.T.; Davis, J.; Oppenheim, A.","year":"1963","unstructured":"Pack GT, Davis J, Oppenheim A. The relation of race and complexion to the are no reports of these drugs giving rise to increased numbers of benign melanocytic naevi. incidence of moles and melanomas. Ann NY Acad Sci 1963;100:719-42.","journal-title":"Ann NY Acad Sci"},{"key":"ref_8","first-page":"732","article-title":"Origin of familial malignant melanomas from heritable melanocvtic lesions. 'The B-K After chemotherapy for haematological malignancies patients have an increased risk of developing second tumours. Greene and Wilson found an excess of malignant melanoma in male patients in a large epidemiological survey ofpatients treated for leukaemia mole syndrome'","volume":"114","author":"Clark, W.H.; Reimer, R.R.; Green, M.; Ainsworth, A.M.; Mastrangelo, M.J.","year":"1978","unstructured":"Clark WH, Reimer RR, Green M, Ainsworth AM, Mastrangelo MJ. Origin of familial malignant melanomas from heritable melanocvtic lesions. 'The B-K After chemotherapy for haematological malignancies patients have an increased risk of developing second tumours. Greene and Wilson found an excess of malignant melanoma in male patients in a large epidemiological survey ofpatients treated for leukaemia mole syndrome'. Arch Dermatol 1978;114:732-8.","journal-title":"Arch Dermatol"},{"key":"ref_9","article-title":"Melanocytic naevi","volume-title":"Textbook of dermatology","author":"MacKie, R.M.","unstructured":"MacKie RM. Melanocytic naevi. In: Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL, eds. Textbook of dermatology. 4th ed. Oxford: Blackwell Scientific, 1986:181.","edition":"4th ed"},{"key":"ref_10","first-page":"25","article-title":"Increased nevus estrogen and progesterone ligand binding related to oral contraceptives or pregnancy","volume":"14","author":"Ellis, D.L.; WCheeland, R.G.","year":"1986","unstructured":"Ellis DL, WCheeland RG. Increased nevus estrogen and progesterone ligand binding related to oral contraceptives or pregnancy. J Am Acad Dermatol 1986;14:25-3 1. and Hodgkin's and non-Hodgkin's lymphomas.'7 This excess did not persist in long term survivors. Most of","journal-title":"J Am Acad Dermatol; 1. and Hodgkin's and non-Hodgkin's lymphomas.'7 This excess did not persist in long term survivors"},{"key":"ref_11","article-title":"Etiology of common acquired melanocytic nevi: constitutional variables, sun exposure and diet. JNCI 1986; 77: 329-35. the data from leukaemic patients relate to adults with chronic lymphatic leukaemia. The long term risks of developing second tumours after acute lymphatic","author":"Armstrong, B.K.; de Kerk, N.H.; Holman, D.J.","unstructured":"Armstrong BK, de Kerk NH, Holman DJ. Etiology of common acquired melanocytic nevi: constitutional variables, sun exposure and diet. JNCI 1986;77:329-35. the data from leukaemic patients relate to adults with chronic lymphatic leukaemia. The long term risks of developing second tumours after acute lymphatic"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0190-9622(88)70090-0","article-title":"Prevalence of common 'acquired' nevocytic nevi and dysplastic nevi is not related to ultraviolet exposure","volume":"18","author":"Rampen, F.H.J.; Fleuren, B.A.M.; de Boo TM\\; Lemmers, W.A.J.G.","year":"1988","unstructured":"Rampen FHJ, Fleuren BAM, de Boo TM\\, Lemmers WAJG. Prevalence of common 'acquired' nevocytic nevi and dysplastic nevi is not related to ultraviolet exposure. J.Am Acad Dermatol 1988;18:679-83.","journal-title":"J. Am Acad Dermatol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2133.1977.tb15182.x","article-title":"Eruptive naes-i: report of two cases, with enzyme histochemical, light and electron microscopical findings","volume":"97","author":"Eady, R.A.J.; Gilkes, J.J.H.; Jones, E.W.","year":"1977","unstructured":"Eady RAJ, Gilkes JJH, Jones EW. Eruptive naes-i: report of two cases, with enzyme histochemical, light and electron microscopical findings. Br J Dermtatol 1977;97:267-78.","journal-title":"Br J Dermtatol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1001\/archderm.1975.01630240114019","article-title":"Eruptive nevi","volume":"111","author":"Coskey, R.J.","year":"1975","unstructured":"Coskey RJ. Eruptive nevi. Arch Dernatol 1975;111: 1658.","journal-title":"Arch Dernatol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1001\/jama.1951.03670270031011","article-title":"Effect of corticotrophin and cortisone on the development and progress of pigmented nevi","volume":"143","author":"Goldman, L.; Richfield, D.F.","year":"1951","unstructured":"Goldman L, Richfield DF. Effect of corticotrophin and cortisone on the development and progress of pigmented nevi. JAMA 1951;143:941-3.","journal-title":"JAMA"},{"key":"ref_16","first-page":"191","article-title":"Second cancer following lymphatic and hematopoietic cancers in Connecticut, 1935-82","volume":"68","author":"Greene, M.H.; Wilson, J.","year":"1985","unstructured":"Greene MH, Wilson J. Second cancer following lymphatic and hematopoietic cancers in Connecticut, 1935-82. NCI Monogr 1985;68:191-219.","journal-title":"NCI Monogr"},{"key":"ref_17","first-page":"211","article-title":"Cancerrisk following treatment of childhood cancer","volume-title":"Radiation carcinogenesis: epidemiology and biological significance","author":"Tucker, M.A.; Meadows, A.T.; BoiceJDJr, etal","year":"1984","unstructured":"Tucker MA, Meadows AT, BoiceJDJr, etal. Cancerrisk following treatment of childhood cancer. In: Boice JD Jr, Fraumeni JF Jr, eds. Radiation carcinogenesis: epidemiology and biological significance. 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BrMedJ 1986;292:1555-9.","journal-title":"BrMedJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ijc.2910350303","article-title":"Common acquired nevi and the risk of malignant melanoma","volume":"35","author":"Green, A.; Maclennan, R.; Siskind, V.","year":"1985","unstructured":"Green A, Maclennan R, Siskind V. Common acquired nevi and the risk of malignant melanoma. Intj Cancer 1985;35:297-300.","journal-title":"Intj Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/1097-0142(194901)2:1<28::AID-CNCR2820020105>3.0.CO;2-N","article-title":"A reorientation on the histogenesis and clinical significance of cutaneous nevi and melanomas","author":"Allen, A.C.","year":"1949","unstructured":"Allen AC. A reorientation on the histogenesis and clinical significance of cutaneous nevi and melanomas. Cancer 1949;28-41.","journal-title":"Cancer"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.299.6691.88","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.299.6691.88","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:33:24Z","timestamp":1765265604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.299.6691.88"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7,8]]},"references-count":23,"journal-issue":{"issue":"6691","published-online":{"date-parts":[[1989,7,8]]},"published-print":{"date-parts":[[1989,7,8]]}},"alternative-id":["10.1136\/bmj.299.6691.88"],"URL":"https:\/\/doi.org\/10.1136\/bmj.299.6691.88","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7,8]]}}}