{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:00:12Z","timestamp":1790229612620,"version":"4.1.0"},"reference-count":8,"publisher":"BMJ","issue":"6695","license":[{"start":{"date-parts":[[1989,8,5]],"date-time":"1989-08-05T00:00:00Z","timestamp":618278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1989,8,5]]},"abstract":"<jats:p>The use of local hyperthermia to treat cancer of the internal organs has been limited by the difficulty of controlling delivery of heat and limiting the effects to the tumour, but this can be overcome by using laser light transmitted through thin flexible fibres. Laser energy was delivered to tumours through fibres inserted percutaneously through needles directly into the centre of the tumour area. Ultrasound scanning was used to locate the tumour, position the fibres correctly within the tumour, and monitor the development of thermal necrosis in real time during laser exposure and through the subsequent period of healing. Five patients were treated (one with a tumour of the breast, one with a subcutaneous secondary tumour, one with a recurrent pancreatic tumour, and two with secondary tumours in the liver). Tumour necrosis was found on ultrasonography or computed tomography in all, and there were no immediate or delayed complications. In one patient the size of the isolated secondary tumour in the liver had not increased over 10 months, and he subsequently showed no other evidence of residual cancer. To develop this technique careful studies are essential to ensure that in every case the extent of thermal necrosis produced by absorption of the laser light can be matched to the full extent of the tumour being treated and that there is always sufficient adjacent normal tissue to ensure safe healing. These preliminary results suggest that this simple technique can be applied safely and effectively to common tumours in humans; more extensive trials in a range of cancers of solid organs are warranted.<\/jats:p>","DOI":"10.1136\/bmj.299.6695.362","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"362-365","source":"Crossref","is-referenced-by-count":164,"title":["Interstitial laser hyperthermia: a new approach to local destruction of tumours."],"prefix":"10.1136","volume":"299","author":[{"given":"A. C.","family":"Steger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. R.","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Walmsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Bown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1989,8,5]]},"reference":[{"key":"ref_1","first-page":"1243","article-title":"*Fhermotherapy for melanoma metastascs in liser","volume":"49","author":"Storm, K.F.; Kaiser, L.-R.; Goodnight, J.E.; ei al","year":"1982","unstructured":"Storm KF, Kaiser L-R, Goodnight JE, ei al. *Fhermotherapy for melanoma metastascs in liser. Cancer 1982;49: 1243-s.","journal-title":"Cancer"},{"key":"ref_2","first-page":"393","article-title":"Microwave indtuccd hy-perthermia and radiotherapy in human superficial tumotirs clinical results with a comparative study of combined treatment versus radiothcrapy alone","volume":"3","author":"Lindholm, C.-E.; K'ellan, E.; Nilson, P.; Hertzman, S.","year":"1987","unstructured":"Lindholm C-E, K'ellan E, Nilson P, Hertzman S. Microwave indtuccd hy-perthermia and radiotherapy in human superficial tumotirs clinical results with a comparative study of combined treatment versus radiothcrapy alone. lnr,7 1esr'ppthermia 1987;3:393-41 1."},{"issue":"10","key":"ref_3","first-page":"4869","article-title":"Whole body hypcrthertmia iinductioni tcchniqtucs","volume":"44","author":"Milligan, A.J.","year":"1984","unstructured":"Milligan AJ. Whole body hypcrthertmia iinductioni tcchniqtucs. Cancer Res 1984;44 (10 Suppl):4869-72.","journal-title":"Cancer Res"},{"key":"ref_4","first-page":"275","article-title":"Intcrstitial radiation therapy for hcpatic metastases: sonographic guidance for applicator placement","volume":"164","year":"1986","unstructured":"Dritclilo A, (irant EG, Harter KW;, Holt RWY, Rustigi SN, Rodgers JE. Intcrstitial radiation therapy for hcpatic metastases: sonographic guidance for applicator placement. Am,7 Radtol 1986;164:275-8."},{"key":"ref_5","first-page":"700","article-title":"Phototherapy of tumors World.7 Surg","volume":"7","author":"Bown, S.G.","year":"1983","unstructured":"Bown SG. Phototherapy of tumors World.7 Surg 1983;7:700-9."},{"key":"ref_6","first-page":"134","article-title":"Ultrasonography guidcd lasers and sphcric lasers","volume-title":"cds. Lasers in gastrocnicrologs","author":"1, Hashimoto","year":"1989","unstructured":"Hashimoto 1). Ultrasonography guidcd lasers and sphcric lasers. In: Ricmann JF, Ell C, cds. Lasers in gastrocnicrologs' Gec)rg Thiemc V'crlag Inc, Stuittgart: Thicmc P'uLblishicrs, 1989:134-8."},{"key":"ref_7","first-page":"949","article-title":"P'ercutaneous ethanol iijectioin in the treatment of liser neoplasms","volume":"149","author":"Shiina, S.; Yasuda, H.; Aluto, H.","year":"1987","unstructured":"Shiina S, Yasuda H, Aluto H, et al. P'ercutaneous ethanol iijectioin in the treatment of liser neoplasms. Amj7 Radiol 1987;149:949-52."},{"key":"ref_8","first-page":"3","article-title":"US-guidcd pcrCutatlcous alcohol iIjectioIn of small hepatic aind abdomiial tuimiors","volume":"161","author":"Livraghi, T.; Ml, Fcsti; Monti, F.; Salmi, A.; Vcttori, C.","year":"1986","unstructured":"Livraghi T, Fcsti Ml, Monti F, Salmi A, Vcttori C. US-guidcd pcrCutatlcous alcohol iIjectioIn of small hepatic aind abdomiial tuimiors. Radiology 1986;161:3(9-12.","journal-title":"Radiology"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.299.6695.362","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.299.6695.362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:44:25Z","timestamp":1765266265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.299.6695.362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8,5]]},"references-count":8,"journal-issue":{"issue":"6695","published-online":{"date-parts":[[1989,8,5]]},"published-print":{"date-parts":[[1989,8,5]]}},"alternative-id":["10.1136\/bmj.299.6695.362"],"URL":"https:\/\/doi.org\/10.1136\/bmj.299.6695.362","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8,5]]}}}