{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:10:55Z","timestamp":1774408255904,"version":"3.50.1"},"reference-count":20,"publisher":"BMJ","issue":"6711","license":[{"start":{"date-parts":[[1989,11,25]],"date-time":"1989-11-25T00:00:00Z","timestamp":627955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1989,11,25]]},"abstract":"<jats:p>STUDY OBJECTIVE--To compare three days' and seven days' treatment with co-trimoxazole in women with acute dysuria, strangury, and urinary frequency or urgency. DESIGN--Randomised double blind placebo controlled trial. SETTING--General practices in the south east of The Netherlands. PATIENTS--327 Non-pregnant female patients aged 12 to 65. INTERVENTION--161 Women were allocated to three days' treatment (co-trimoxazole 960 mg twice a day), and 166 women were allocated to seven days' treatment (co-trimoxazole 960 mg twice a day). MAIN OUTCOME MEASURE--Resolution of symptoms at one, two, and six weeks. RESULTS--The rates for resolution of symptoms were not significantly different between the two groups. Cumulative rates of recurrence after three days' and seven days' treatment were 31\/139 (22%) and 23\/151 (15%) respectively six weeks after entry (p = 0.16). Adverse effects occurred in a quarter of women given three days' treatment compared with a third of women receiving seven days' treatment (p = 0.29). In only two patients did adverse effects necessitate stopping treatment. CONCLUSIONS--Three days of co-trimoxazole seems to be as effective as a seven days' course for treating acute urinary tract infection in non-pregnant women.<\/jats:p>","DOI":"10.1136\/bmj.299.6711.1319","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1319-1322","source":"Crossref","is-referenced-by-count":28,"title":["Different lengths of treatment with co-trimoxazole for acute uncomplicated urinary tract infections in women."],"prefix":"10.1136","volume":"299","author":[{"given":"T. A.","family":"Trienekens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. E.","family":"Stobberingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Winkens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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