{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:55:28Z","timestamp":1765281328556,"version":"3.46.0"},"reference-count":0,"publisher":"BMJ","issue":"5667","license":[{"start":{"date-parts":[[1969,8,16]],"date-time":"1969-08-16T00:00:00Z","timestamp":-11923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1969,8,16]]},"abstract":"<jats:p>Intravenous lignocaine (1 mg.\/kg. body weight) was found to produce insignificant haemodynamic changes, and in particular no reduction in myocardial contractility. A rate of 2 mg.\/minute infused intravenously is suggested for therapeutic purposes.<\/jats:p>\n                  <jats:p>In anaesthetized dogs an infusion of 13\u00b75 mg.\/minute caused moderate haemodynamic depression and a maximum plasma level of 7 \u03bcg.\/ml. Massive injections of 200 and 400 mg. of lignocaine produced a maximum plasma level of 13\u00b78 and 27\u00b78 \u03bcg.\/ml., respectively, and in the latter failure of myocardial contraction in the presence of a normal E.C.G. ensued (\u201cpump failure\u201d). Lignocaine appears to alter the uptake of calcium by myocardial sarcoplasmic reticulum, and this may explain the negative inotropic effect of large doses.<\/jats:p>","DOI":"10.1136\/bmj.3.5667.390","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T07:02:10Z","timestamp":1238655730000},"page":"390-392","source":"Crossref","is-referenced-by-count":25,"title":["Relation between Plasma Lignocaine Levels and Induced Haemodynamic Changes"],"prefix":"10.1136","volume":"3","author":[{"given":"P. F.","family":"Binnion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Murtagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,8,16]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.3.5667.390","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.3.5667.390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:23:07Z","timestamp":1765279387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.3.5667.390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,8,16]]},"references-count":0,"journal-issue":{"issue":"5667","published-online":{"date-parts":[[1969,8,16]]},"published-print":{"date-parts":[[1969,8,16]]}},"alternative-id":["10.1136\/bmj.3.5667.390"],"URL":"https:\/\/doi.org\/10.1136\/bmj.3.5667.390","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1969,8,16]]}}}