{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:37:02Z","timestamp":1765287422133,"version":"3.46.0"},"reference-count":0,"publisher":"BMJ","issue":"5817","license":[{"start":{"date-parts":[[1972,7,1]],"date-time":"1972-07-01T00:00:00Z","timestamp":78796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1972,7,1]]},"abstract":"<jats:p>Morning plasma 11-hydroxycorticoids, urinary 11-hydroxycorticoids, and urinary 17-oxogenic steroids were measured before and during a dexamethasone suppression test. This consisted in the administration by mouth of 2 mg of dexamethasone daily for 48 hours, followed by 8 mg daily for 48 hours. In addition midnight plasma 11-hydroxycorticoids were measured before the start of the test. The subjects investigated were 21 patients with Cushing's syndrome, 27 obese female patients, 10 female patients with the Stein-Leventhal syndrome, and 8 female patients with idiopathic hirsutism.<\/jats:p>\n                  <jats:p>The results showed that the clearest distinction between the groups was made by measurement of the basal urinary 11-hydroxycorticoid excretion, where, in the group of patients with Cushing's syndrome, all the levels were well above the upper limit of normal. In addition raised midnight plasma 11-hydroxycorticoid levels were of great diagnostic value. By using these results together with those of the dexamethasone suppression tests it was possible to make a firm preoperative diagnosis of pituitary-dependent Cushing's syndrome in 90% of patients in this series.<\/jats:p>","DOI":"10.1136\/bmj.3.5817.17","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"17-21","source":"Crossref","is-referenced-by-count":7,"title":["Plasma and Urinary 11-Hydroxycorticosteroids in Differential Diagnosis of Cushing's Syndrome"],"prefix":"10.1136","volume":"3","author":[{"given":"D.","family":"Mattingly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,7,1]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.3.5817.17","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.3.5817.17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:32:34Z","timestamp":1765287154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.3.5817.17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,7,1]]},"references-count":0,"journal-issue":{"issue":"5817","published-online":{"date-parts":[[1972,7,1]]},"published-print":{"date-parts":[[1972,7,1]]}},"alternative-id":["10.1136\/bmj.3.5817.17"],"URL":"https:\/\/doi.org\/10.1136\/bmj.3.5817.17","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1972,7,1]]}}}