{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:32:29Z","timestamp":1765481549794,"version":"3.48.0"},"reference-count":0,"publisher":"BMJ","issue":"5924","license":[{"start":{"date-parts":[[1974,7,20]],"date-time":"1974-07-20T00:00:00Z","timestamp":143510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1974,7,20]]},"abstract":"<jats:p>In February 1972 58% of patients euthyroid after iodine-131 therapy given for thyrotoxicosis between 1954 and 1966 had a high plasma TSH (&gt;7\u00b74 \u03bcU\/ml) and 42% a normal plasma TSH level. A group of 69 of the euthyroid patients with high plasma TSH levels (25\u00b70\u00b12\u00b70 \u03bcU\/ml) in 1972 were re-examined 15 and 24 months later. The mean plasma TSH in the 66 patients remaining euthyroid at 15 months was 22\u00b76\u00b11\u00b78 \u03bcU\/ml, while three patients had become hypothyroid. At 24 months 64 of the patients were still available for study, of whom 61 remained euthyroid with a mean plasma TSH of 21\u00b76\u00b12\u00b70 \u03bcU\/ml, and a further three had become hypothyroid.<\/jats:p>\n                  <jats:p>All of a group of 61 of the euthyroid patients with normal plasma TSH levels (4\u00b70\u00b10\u00b72 \u03bcU\/ml) in 1972 remained euthyroid at 24 months with a mean plasma TSH of 4\u00b71\u00b10\u00b73 \u03bcU\/ml, though the plasma TSH level had become slightly raised in three.<\/jats:p>\n                  <jats:p>The mean serum T-4 level in the euthyroid patients with a high plasma TSH was significantly lower, though still in the normal range, than that in the euthyroid patients with a normal plasma TSH both in 1972 and in 1974.<\/jats:p>\n                  <jats:p>Since no patient with a normal plasma TSH level after iodine-131 treatment six to 18 years earlier for thyrotoxicosis developed hypothyroidism over a two-year period, the follow-up of such patients need not be so rigorous as that of similarly treated euthyroid patients with raised plasma TSH levels in whom hypothyroidism developed at the rate of 5% per year.<\/jats:p>","DOI":"10.1136\/bmj.3.5924.152","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"152-153","source":"Crossref","is-referenced-by-count":13,"title":["Plasma TSH and Serum T-4 Levels in Long-term Follow-up of Patients Treated with\n                    <sup>131<\/sup>\n                    I for Thyrotoxicosis"],"prefix":"10.1136","volume":"3","author":[{"given":"A. D.","family":"Toft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. J.","family":"Irvine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Seth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,7,20]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.3.5924.152","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.3.5924.152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:27:45Z","timestamp":1765481265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.3.5924.152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,7,20]]},"references-count":0,"journal-issue":{"issue":"5924","published-online":{"date-parts":[[1974,7,20]]},"published-print":{"date-parts":[[1974,7,20]]}},"alternative-id":["10.1136\/bmj.3.5924.152"],"URL":"https:\/\/doi.org\/10.1136\/bmj.3.5924.152","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1974,7,20]]}}}