{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:57:59Z","timestamp":1765483079425,"version":"3.48.0"},"reference-count":0,"publisher":"BMJ","issue":"5929","license":[{"start":{"date-parts":[[1974,8,24]],"date-time":"1974-08-24T00:00:00Z","timestamp":146534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1974,8,24]]},"abstract":"<jats:p>Twelve of the 100 family contacts of 29 patients with transient and persistent hepatitis B antigenaemia were found to be positive for hepatitis B antigen (HBAg). No relation was found between familial clustering and the nature of liver disease or the duration of antigenaemia in the index cases.<\/jats:p>\n                  <jats:p>Eight affected relatives were apparently healthy carriers of HBAG, one had cirrhosis, and three (in the same family) developed acute viral hepatitis.<\/jats:p>\n                  <jats:p>The absence of parenteral exposure in the HBA,-positive family contacts and the identity in antigenic determinants d or y with those of the index cases, suggest a non-parenteral spread of HBAg in families of patients with HBAg-associated liver diseases.<\/jats:p>","DOI":"10.1136\/bmj.3.5929.495","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"495-497","source":"Crossref","is-referenced-by-count":9,"title":["Familial Clustering of Hepatitis B Antigen: A Study in Relatives of Patients with Liver Diseases and Hepatitis B Antigenaemia"],"prefix":"10.1136","volume":"3","author":[{"given":"Miguel","family":"Bruguera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Rod\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Pedreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,8,24]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.3.5929.495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.3.5929.495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:55:26Z","timestamp":1765482926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.3.5929.495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,8,24]]},"references-count":0,"journal-issue":{"issue":"5929","published-online":{"date-parts":[[1974,8,24]]},"published-print":{"date-parts":[[1974,8,24]]}},"alternative-id":["10.1136\/bmj.3.5929.495"],"URL":"https:\/\/doi.org\/10.1136\/bmj.3.5929.495","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1974,8,24]]}}}