{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:31:42Z","timestamp":1770823902032,"version":"3.50.1"},"reference-count":7,"publisher":"BMJ","issue":"6720","license":[{"start":{"date-parts":[[1990,2,3]],"date-time":"1990-02-03T00:00:00Z","timestamp":634003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1990,2,3]]},"abstract":"<jats:p>OBJECTIVE--To determine the accuracy of midtrimester diagnosis of fetal abnormality by examination and investigation of fetuses after induced abortion. DESIGN--Prospective study over five years of fetuses aborted in the midtrimester because of abnormalities detected by ultrasonography and amniocentesis. Techniques included a full external examination by a clinical geneticist with experience in dysmorphology and other investigations including necropsy. SETTING--Regional genetic centre. PARTICIPANTS--Clinicians working within the North Western region who wished to use the service offered. RESULTS--133 Fetuses were aborted because of abnormalities detected on ultrasonography and 115 because of abnormal findings on amniotic fluid analysis. In a further two cases fetal abnormality was diagnosed by molecular genetic and biochemical techniques. Among the fetuses with abnormal scans the pretermination diagnosis was changed or refined in a way which affected genetic counselling in 53 of 133 cases. Among the 115 fetuses diagnosed as abnormal by amniocentesis the pretermination diagnosis was confirmed in 112 cases and altered in three. CONCLUSION--Fetuses aborted because of abnormalities detected by screening should be examined by suitably experienced clinicians, both for accurate genetic counselling of the families and for quality control of the tests employed.<\/jats:p>","DOI":"10.1136\/bmj.300.6720.295","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"295-297","source":"Crossref","is-referenced-by-count":44,"title":["Examination of fetuses after induced abortion for fetal abnormality."],"prefix":"10.1136","volume":"300","author":[{"given":"J","family":"Clayton-Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Farndon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"McKeown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Donnai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,2,3]]},"reference":[{"key":"ref_1","first-page":"737","article-title":"'rhe management of the patient having fetal diagnosis. Ballllwr,\"s Clin Obsiet Gynaecol","volume":"1","author":"Donnai, D.","year":"1987","unstructured":"Donnai D. 'rhe management of the patient having fetal diagnosis. Ballllwr,\"s Clin Obsiet Gynaecol 1987;1:737-45."},{"key":"ref_2","first-page":"40","article-title":"'T'he pathologicil examination of the infant and examination of the placetrta. In: I'hmnsl\/Ormcd fetus and stillbirth","author":"Winter, R.M.; Knowles, S.A.S.; Bieber, F.R.; Baraitser, M.","year":"1988","unstructured":"Winter RM, Knowles SAS, Bieber FR, Baraitser M. 'T'he pathologicil examination of the infant and examination of the placetrta. In: I'hmnsl\/Ormcd fetus and stillbirth. Chichester: John Wiley and Sons, 1988:40-68."},{"key":"ref_3","article-title":"Place of structured request forms in prettatal pathology. In: Fetal and neonatal pathology","author":"Kelling, J.W.","year":"3.","unstructured":"Kelling JW, ed. Place of structured request forms in prettatal pathology. In: Fetal and neonatal pathology. London: Springer 'Verlag, 1987:3."},{"key":"ref_4","first-page":"51","article-title":"Prenatal detection ofla fittilihal nuchal bleb simulating encephalocele","volume":"15","author":"Bieber, F.R.; Petres, R.F.; Bieber, J.M.; Nanice, W.E.","year":"1979","unstructured":"Bieber FR, Petres RF, Bieber JM, Nanice WE. Prenatal detection ofla fittilihal nuchal bleb simulating encephalocele. Birth Defects 1979;15:51-61.","journal-title":"Birth Defects"},{"key":"ref_5","first-page":"97","article-title":"Encephalocele, polycystic kidnrcys atid polycdactviv s; autosomal recessive trait simulating certain other disorders: tile MeCk1cl syndrome","volume":"14","author":"Meckel, S.; Pessarge, E.","year":"1971","unstructured":"Meckel S, Pessarge E. Encephalocele, polycystic kidnrcys atid polycdactviv s; autosomal recessive trait simulating certain other disorders: tile MeCk1cl syndrome. Ann Genet 1971;14:97.","journal-title":"Ann Genet"},{"issue":"56","key":"ref_6","first-page":"53","article-title":"'rhe OEIS conmplex (onitphlalocclc, exstrophy, imperforate anus, spinal defects)","volume":"1","author":"Carey, J.C.; Greenbaum, B.; Hall, B.D.","year":"1978","unstructured":"Carey JC, Greenbaum B, Hall BD. 'rhe OEIS conmplex (onitphlalocclc, exstrophy, imperforate anus, spinal defects). Birth De\/icts 1978;1 56B:2 53-63.","journal-title":"Birth De\/icts"},{"key":"ref_7","first-page":"210","article-title":"Smith's recognisable patterns of human malfisrmations. 4ttl Cd","author":"Jones, K.L.","year":"1988","unstructured":"Jones KL. Smith's recognisable patterns of human malfisrmations. 4ttl Cd. Philadelphia: W B Saunders, 1988:210-1."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.300.6720.295","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.300.6720.295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:33:38Z","timestamp":1765488818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.300.6720.295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2,3]]},"references-count":7,"journal-issue":{"issue":"6720","published-online":{"date-parts":[[1990,2,3]]},"published-print":{"date-parts":[[1990,2,3]]}},"alternative-id":["10.1136\/bmj.300.6720.295"],"URL":"https:\/\/doi.org\/10.1136\/bmj.300.6720.295","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2,3]]}}}