{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:05:26Z","timestamp":1791158726219,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","issue":"6728","license":[{"start":{"date-parts":[[1990,3,31]],"date-time":"1990-03-31T00:00:00Z","timestamp":638841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1990,3,31]]},"abstract":"<jats:p>OBJECTIVE--To compare the outcome of pregnancy in women with and without renal scarring after childhood urinary infections with that in unmatched controls. DESIGN--Retrospective study of pregnancies in women prospectively followed up from their first recognised urinary infection. SETTING--Tertiary referral centre in Gothenburg. SUBJECTS--111 Women attending an outpatient clinic for women with urinary infection during 1975-83, of whom 41 (65 pregnancies) were studied (19 women with renal scarring (32), 22 without scarring (33)), and 65 controls (65) randomly selected and matched for parity, age, smoking habits, and date of delivery. MAIN OUTCOME MEASURES--Urinary infections and complications in pregnancy. RESULTS--The incidence of bacteriuria during first pregnancies was significantly greater in women with (9, 47%) and without (6, 27%) renal scarring after childhood urinary infection than in controls (1, 2%) (p less than 0.001, 0.01 respectively). Symptomatic infections were seen only among women with a history of urinary infection: four women with renal scarring (three of whom had vesicoureteric reflux) developed pyelonephritis and three cystitis, and one woman without scarring developed pyelonephritis. Mean blood pressure was higher among women with severe renal scarring than controls (4\/11 v 3\/44; p less than 0.05) before and during pregnancy. There was no significant difference in the incidence of pre-eclampsia, operative delivery, prematurity, or birth weight. CONCLUSIONS--Women with a history of previous urinary infections had a high incidence of bacteriuria during pregnancy, and those with renal scarring and persistent reflux were prone to develop acute pyelonephritis. The risk of serious complications in pregnancy, however, was not increased in women with severe renal scarring, possibly owing to their continuous clinical supervision.<\/jats:p>","DOI":"10.1136\/bmj.300.6728.840","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"840-844","source":"Crossref","is-referenced-by-count":72,"title":["Pregnancies in women with and without renal scarring after urinary infections in childhood."],"prefix":"10.1136","volume":"300","author":[{"given":"J","family":"Martinell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Jodal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Lidin-Janson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1990,3,31]]},"reference":[{"key":"ref_1","first-page":"21","article-title":"Reflux ttephropathv in the adult. Int: Hodsoll","author":"Kincaid-Smith, P.; Bccker, G.J.","year":"1979","unstructured":"Kincaid-Smith P, Bccker GJ. Reflux ttephropathv in the adult. Int: Hodsoll J Kincaid-Smith P, eds. Reflux nephropathts. New York: Masson, 1979:21-8."},{"issue":"1 -20","key":"ref_2","article-title":"Epidemiology of symptomatic urinary tract intection in childhood","volume":"252","author":"Winberg, J.; Andersett, H.J.; Bergstri4ti, T.; Larsoni, Jacobssoln B.; H, Lincoln; K.","year":"1974","unstructured":"Winberg J, Andersett HJ, Bergstri4ti T, Jacobssoln B. Larsoni H, Lincoln K. Epidemiology of symptomatic urinary tract intection in childhood. Acta Paediatr Scatid 1974;suppl 252:1 -20.","journal-title":"Acta Paediatr Scatid"},{"key":"ref_3","first-page":"611","article-title":"Thc niatural history ot bacteriuria in childhood. ItnfLtsi(ous Disease Clinicsofl.\\orthlArnerica 1987; 1: 713-29. 5 (, ranerus (G, AuLrell AM. Refcrence valucs for; lCr-EDTA clearancc as a measure of glomertular filtration rate. Scandj Clin Lab Invest","volume":"41","author":"Jodal, U.","year":"1981","unstructured":"Jodal U. Thc niatural history ot bacteriuria in childhood. ItnfLtsi(ous Disease Clinicsofl.\\orthlArnerica 1987;1:713-29. 5 (,ranerus (G, AuLrell AM. Refcrence valucs for;lCr-EDTA clearancc as a measure of glomertular filtration rate. Scandj Clin Lab Invest 1981;41:611-6."},{"key":"ref_4","first-page":"191","article-title":"Natural history of chronic pyclonephritic scarring","volume":"ii:","author":"Hodson Cj, W.'ilson S.","year":"1965","unstructured":"Hodson Cj, W'ilson S. Natural history of chronic pyclonephritic scarring. Brrledj 1965;ii: 191-4.","journal-title":"Brrledj"},{"key":"ref_5","first-page":"65","article-title":"XVesico-urcteric rcflux and rCnal scarring","volume":"8","author":"Smellic, J.; Edwards, D.; Hunter, N.; Normand, I.C.S.; Prescod, N.","year":"1975","unstructured":"Smellic J, Edwards D, Hunter N, Normand ICS, Prescod N. XVesico-urcteric rcflux and rCnal scarring. Kidney Itit 1975;8:65-72.","journal-title":"Kidney Itit"},{"key":"ref_6","first-page":"105","article-title":"Ititernational Reflux Stuidy in Children. International svstem of radiographic grading of vesicoureteric refluix","volume":"15","year":"1985","unstructured":"Ititernational Reflux Stuidy in Children. International svstem of radiographic grading of vesicoureteric refluix. PediatrRadiiol 1985;15:105-9.","journal-title":"PediatrRadiiol"},{"issue":"5","key":"ref_7","first-page":"18","article-title":"Arguments for Fisher's permutation tcst","volume":"3","author":"Odeni, A.; Wedel, H.","year":"1975","unstructured":"Odeni A, Wedel H. Arguments for Fisher's permutation tcst. Annals of Statiasisiss 1975;3:5 18-20.","journal-title":"Annals of Statiasisiss"},{"key":"ref_8","article-title":"\/)isiribtiiiosn free statistical tests","author":"Bradley, J.W.","year":"1968","unstructured":"Bradley JW. \/)isiribtiiiosn free statistical tests. ILondon: lPreittis Hall, 1968."},{"issue":"4","key":"ref_9","article-title":"'crrier-Jones","volume":"991","author":"Sacks, S.H.; Roberts, R.","year":"1987","unstructured":"Sacks SH, Roberts R, 'crrier-Jones K, Asscher AW, Lcdingham JGG. Effect of symptomless bacteriuria in childhood on subsequent pregnancy. Lancet 1987;ii:991 -4.","journal-title":"Lancet; Effect of symptomless bacteriuria in childhood on subsequent pregnancy"},{"key":"ref_10","first-page":"1579","article-title":"Is screcning for bacteriuria worth while?","volume":"294","author":"Campbcll-Brown, A.M.; MlcFadven, I.R.; Seal, D.V.; Stephenson, M.L.","year":"1987","unstructured":"Campbcll-Brown AM, MlcFadven IR, Seal DV, Stephenson ML. Is screcning for bacteriuria worth while? BrM.led] 1987;294: 1579-82.","journal-title":"BrM.led]"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/inf.1985.17.issue-2.11","article-title":"Asymptomatic bacteriuria durinig pregnancy with special reference to group B streptococci","volume":"17","author":"Iiersson, K.; Kvist-Christenseit, K.; Christensen, P.; Forsgren, A.; J6rgenseni, C.; Persson, P.-H.","year":"1985","unstructured":"Iiersson K, Kvist-Christenseit K, Christensen P, Forsgren A, J6rgenseni C, Persson P-H. Asymptomatic bacteriuria durinig pregnancy with special reference to group B streptococci. ScandjI Infcit Dis 1985;17:195-9.","journal-title":"ScandjI Infcit Dis"},{"key":"ref_12","first-page":"285","article-title":"Disappcarancc of sesicouretcric reflux during long term prophylaxis of Uriniary tract infcction in children","volume":"ii:","author":"Edwards, D.; Normand, I.C.S.; Prcscod, N.; Smellie, J.","year":"1977","unstructured":"Edwards D, Normand ICS, Prcscod N, Smellie J. Disappcarancc of sesicouretcric reflux during long term prophylaxis of Uriniary tract infcction in children. BrMedj 1977;ii:285-8.","journal-title":"BrMedj"},{"key":"ref_13","first-page":"249","article-title":"Morphologic chaniges in the renal tract in pregnancy","volume":"28","author":"Bedoun, S.N.","year":"1985","unstructured":"Bedoun SN. Morphologic chaniges in the renal tract in pregnancy. C\/slln Obsite Gvnecol 1985;28:249-56.","journal-title":"C\/slln Obsite Gvnecol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/00003081-197809000-00022","article-title":"Clinical implications of ureteral reflux in pregnancy","volume":"21","author":"Mattingly, R.F.; Borkowf, H.I.","year":"1978","unstructured":"Mattingly RF, Borkowf HI. Clinical implications of ureteral reflux in pregnancy. Clin Obstet Gs'n'col 1978;21:863-73.","journal-title":"Clin Obstet Gs'n'col"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/00365548909035682","article-title":"Host response in women with svnuptormatic urinary tract","volume":"21","author":"Sandberg 'I, Lidin-Janson G, Svandborg-Edn C","year":"1989","unstructured":"Sandberg 'I, Lidin-Janson G, Svandborg-Edn C. Host response in women with svnuptormatic urinary tract infection.,Scandj Infect Dis 1989;21:67-73.","journal-title":"infection., Scandj Infect Dis"},{"key":"ref_16","article-title":"Pregnsancy outcome ins women with refltix nephropathy a rcsicw ol experience at the Roual Women's Hospital","author":"Weaser, E.; Craswell, P.","year":"1977","unstructured":"Weaser E, Craswell P. Pregnsancy outcome ins women with refltix nephropathy a rcsicw ol experience at the Roual Women's Hospital, Brisbane, 1977-"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.300.6728.840","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.300.6728.840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:59:48Z","timestamp":1765490388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.300.6728.840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3,31]]},"references-count":16,"journal-issue":{"issue":"6728","published-online":{"date-parts":[[1990,3,31]]},"published-print":{"date-parts":[[1990,3,31]]}},"alternative-id":["10.1136\/bmj.300.6728.840"],"URL":"https:\/\/doi.org\/10.1136\/bmj.300.6728.840","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3,31]]}}}