{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:39:45Z","timestamp":1791401985792,"version":"4.3.3"},"reference-count":7,"publisher":"BMJ","issue":"6741","license":[{"start":{"date-parts":[[1990,6,30]],"date-time":"1990-06-30T00:00:00Z","timestamp":646704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1990,6,30]]},"abstract":"<jats:p>OBJECTIVE--To determine the efficacy and morbidity of fine loop diathermy excision of the cervical transformation zone as applied to the management of outpatients with abnormal cervical smears. DESIGN--Prospective programme trial with six month follow up. SETTING--Two hospital based colposcopy clinics. PATIENTS--616 Patients aged 16-60 with abnormal cervical smears. INTERVENTIONS--After colposcopic and cytological assessment excision of the cervical transformation zone by fine loop diathermy under local anaesthesia in the outpatient department. MAIN OUTCOME MEASURES--Time to complete the treatment, immediate morbidity in terms of discomfort and bleeding, and cytological and colposcopic findings at six months. RESULTS--Treatment was completed in a mean of 3.47 minutes (SD 1.99). Immediate morbidity was minimal, and histological specimens were adequate in over 90% of cases. Almost two thirds of patients were treated at their first visit to the clinic. 58 Patients (9.4%) failed to attend for follow up at six months and one had had a hysterectomy. Of the 557 patients who attended for colposcopic and cytological follow up at six months, 506 (91%) were normal cytologically and 19 (3.4%) had histologically confirmed persistence of cervical intraepithelial neoplasia. The overall confirmed failure rate of the technique was 4.4%. CONCLUSION--Loop diathermy excision is an effective treatment with low morbidity and is an appropriate modality for patients with abnormal cervical smears.<\/jats:p>","DOI":"10.1136\/bmj.300.6741.1690","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1690-1693","source":"Crossref","is-referenced-by-count":167,"title":["Loop diathermy excision of the cervical transformation zone in patients with abnormal cervical smears."],"prefix":"10.1136","volume":"300","author":[{"given":"D M","family":"Luesley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cullimore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C W","family":"Redman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F G","family":"Lawton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Emens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P","family":"Rollason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E J","family":"Buxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1990,6,30]]},"reference":[{"key":"ref_1","series-title":"Proceedings of International Federation for Cervical Pathology and Colposcopy","article-title":"Use of the diathermy loop in the diagnosis and treatment of lesions of the uterine cervix","author":"Cartier, R.; Sopena, B.; Cartier, I.","year":"1981","unstructured":"Cartier R, Sopena B, Cartier I. Use of the diathermy loop in the diagnosis and treatment of lesions of the uterine cervix [Abstract]. Proceedings of International Federation for Cervical Pathology and Colposcopy. London, 1981."},{"key":"ref_2","first-page":"773","article-title":"A low voltage diathermy loop for taking cervical biopsies. A qualitative comparison with punch biopsy forceps. BrJ'","volume":"93","author":"Prendiville, W.; Sheperd, A.; Davies, W.A.R.","year":"1986","unstructured":"Prendiville W, Sheperd A, Davies WAR. A low voltage diathermy loop for taking cervical biopsies. A qualitative comparison with punch biopsy forceps. BrJ' Obstet Gynaecol 1986;93:773-6.","journal-title":"Obstet Gynaecol"},{"key":"ref_3","first-page":"88","article-title":"Tomlinson","volume":"ii:","author":"Woodman, C.B.J.; Williams, D.; Yates, M.","year":"1989","unstructured":"Woodman CBJ, Williams D, Yates M, Tomlinson K, Ward K, Luesley DM. Indicators of effective cytological sampling of the uterine cervix. Lancet 1989;ii:88-90.","journal-title":"Lancet; Indicators of effective cytological sampling of the uterine cervix"},{"key":"ref_4","first-page":"699","article-title":"A retrospective review of adenocarcinoma-in-situ and glandular atypia of the uterine cervix. BrJ7 Obstet Gynaecol","volume":"94","author":"Luesley, D.M.; Jordan, J.A.; Woodman, C.B.J.; Watson, N.; Williams, D.R.; Waddell, C.","year":"1987","unstructured":"Luesley DM, Jordan JA, Woodman CBJ, Watson N, Williams DR, Waddell C. A retrospective review of adenocarcinoma-in-situ and glandular atypia of the uterine cervix. BrJ7 Obstet Gynaecol 1987;94:699-703."},{"key":"ref_5","series-title":"Gynaecological laser surgery (proceedings ofthe XV RCOG study group","first-page":"127","article-title":"Are we vaporizing microinvasive lesions?","author":"Anderson, M.C.","year":"1985","unstructured":"Anderson MC. Are we vaporizing microinvasive lesions? In: Sharp F, Jordan JA, eds. Gynaecological laser surgery (proceedings ofthe XV RCOG study group). London: Perinatology Press, 1985:127-32."},{"key":"ref_6","first-page":"394","article-title":"The treatment of cervical intraepithelial neoplasia by laser vaporization. Br J7 Obstet Gynaecol","volume":"92","author":"Jordan, J.A.; Woodman, C.B.J.; Myelotte, M.J.","year":"1985","unstructured":"Jordan JA, Woodman CBJ, Myelotte MJ, et al. The treatment of cervical intraepithelial neoplasia by laser vaporization. Br J7 Obstet Gynaecol 1985;92: 394-8."},{"key":"ref_7","series-title":"Royal College of Obstetricians and Gynaecologists; Pre-clinical neoplasia ofthe cervix (proceedings ofthe IX RCOG study group","article-title":"Treatment of CIN by destruction 'cold' coagulator","author":"Duncan, I.D.","year":"1981","unstructured":"Duncan ID. Treatment of CIN by destruction 'cold' coagulator. In: Jordan JA, Sharp F, Singer A, eds. Pre-clinical neoplasia ofthe cervix (proceedings ofthe IX RCOG study group). London: Royal College of Obstetricians and Gynaecologists, 1981:197-204."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.300.6741.1690","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.300.6741.1690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T22:38:48Z","timestamp":1765492728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.300.6741.1690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6,30]]},"references-count":7,"journal-issue":{"issue":"6741","published-online":{"date-parts":[[1990,6,30]]},"published-print":{"date-parts":[[1990,6,30]]}},"alternative-id":["10.1136\/bmj.300.6741.1690"],"URL":"https:\/\/doi.org\/10.1136\/bmj.300.6741.1690","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6,30]]}}}