{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T22:57:24Z","timestamp":1765493844182,"version":"3.48.0"},"reference-count":26,"publisher":"BMJ","issue":"6747","license":[{"start":{"date-parts":[[1990,8,11]],"date-time":"1990-08-11T00:00:00Z","timestamp":650332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1990,8,11]]},"abstract":"<jats:p>OBJECTIVE--To evaluate the need for a randomised study of treatment of spinal osteoporosis with human parathyroid peptide in the secondary prevention of crush fractures; to study the effect of human parathyroid hormone peptide 1-34 plus sex hormones on vertebral body cancellous bone; and, separately, to determine the effect of relatively low doses of sodium fluoride plus calcium on spinal bone mineral density. DESIGN--Open study of patients with primary or postmenopausal osteoporosis. All patients had serial bone densitometry of the spine by quantitative computed tomography and dual photon absorptiometry as well as serial densitometry of the radial midshaft (cortical) and radial distal (trabecular) bone by quantitative computed tomography. Changes in the spinal bone not forming the spongiosa of the vertebral bodies (\"cortical\" bone) were determined from the difference between the two axial measurements, after correction to the same units of measurement. SETTING--Northwick Park Hospital and Medical Research Council Clinical Research Centre. PATIENTS--24 Patients who fulfilled the conventional criteria for type 1 (vertebral) osteoporosis not secondary to recognised causes other than sex hormone deficiency and with at least one crush or wedge vertebral fracture and a spinal bone density (quantitative computed tomography) less than 80 mg\/cm3 or two or more fractures. Twelve patients received human parathyroid peptide and 12 sodium fluoride; they were not randomised. MAIN OUTCOME MEASURES--Trends in axial and peripheral bone mass values determined by linear, time dependent regression analyses. RESULTS--The patients receiving the peptide showed a substantial increase in vertebral spongiosa (mean 25.6 mg\/cm2 two years after the start of treatment). No significant changes were seen in spinal cortical or radial bone density. The patients receiving sodium fluoride showed roughly equal increases in cancellous and cortical bone over the same period (mean increase in vertebral spongiosa 16.1 mg\/cm3). No significant changes were seen in radial bone. CONCLUSIONS--Treatment of postmenopausal women with human parathyroid peptide selectively increases spinal cancellous bone density by amounts that may prove useful in secondary prevention. Peptide treatment should now be tested in a randomised study in which the important end point is prevention of fractures as the usefulness of sodium fluoride in this context is doubtful.<\/jats:p>","DOI":"10.1136\/bmj.301.6747.314","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"314-318","source":"Crossref","is-referenced-by-count":90,"title":["Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride."],"prefix":"10.1136","volume":"301","author":[{"given":"J","family":"Reeve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U M","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hesp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"McNally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,8,11]]},"reference":[{"key":"ref_1","first-page":"1340","article-title":"The anabolic effect of human parathyroid hormone fragment (hPTH 1-34) therapy on trabecular bone in involutional osteoporosis: report of a multi-centre trial. Br MedJ3","volume":"280","author":"Reeve, J.; Meunier, P.J.; Parsons, J.A.","year":"1980","unstructured":"Reeve J, Meunier PJ, Parsons JA, et al. The anabolic effect of human parathyroid hormone fragment (hPTH 1-34) therapy on trabecular bone in involutional osteoporosis: report of a multi-centre trial. Br MedJ3 1980;280: 1340-4."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0221-8747(80)90006-5","article-title":"Effect of combined therapy with phosphate and calcitonin on bone volume in osteoporosis","volume":"2","author":"Rasmussen, H.; Bordier, P.; Marie, P.","year":"1980","unstructured":"Rasmussen H, Bordier P, Marie P, et al. Effect of combined therapy with phosphate and calcitonin on bone volume in osteoporosis. Metabolic Bone Disease and Related Research 1980;2: 107-1 1.","journal-title":"Metabolic Bone Disease and Related Research"},{"key":"ref_3","first-page":"595","article-title":"Treatment of primary osteoporosis with drugs that increase bone formation: sodium fluoride, hPTH 1-34, ADFR concept","volume":"2","author":"Meunier, P.J.; Galus, K.; Briancon, D.","year":"1984","unstructured":"Meunier PJ, Galus K, Briancon D, et al. Treatment of primary osteoporosis with drugs that increase bone formation: sodium fluoride, hPTH 1-34, ADFR concept. In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL, eds. Osteoporosis. Vol 2. Aalborg: Stiftsbogtrykkeri, 1984:595-602."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/8756-3282(86)90147-X","article-title":"Mechanisms underlying the effect of phosphate and calcitonin on bone histology in postmenopausal osteoporosis","volume":"7","author":"Marie, P.J.; Caulin, F.","year":"1986","unstructured":"Marie PJ, Caulin F. Mechanisms underlying the effect of phosphate and calcitonin on bone histology in postmenopausal osteoporosis. Bone 1986;7: 17-22.","journal-title":"Bone"},{"key":"ref_5","first-page":"160","article-title":"Human parathyroid peptide (hPTH 1-34) treatment increases the mean wall thickness of iliac trabecular packets of new bone in patients with crush fracture osteoporosis","volume":"3","author":"Bradbeer, J.N.; Arlot, M.; Reeve, J.; Meunier, P.J.","year":"1988","unstructured":"Bradbeer JN, Arlot M, Reeve J, Meunier PJ. Human parathyroid peptide (hPTH 1-34) treatment increases the mean wall thickness of iliac trabecular packets of new bone in patients with crush fracture osteoporosis. Journal of Bone and Mineral Research 1988;3:S 160.","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0221-8747(81)90018-7","article-title":"The relationship between changes in femoral bone density and calcium balance in patients with involutional osteoporosis treated with human parathyroid hormone fragment (hPTH 1-34)","volume":"2","author":"Hesp, R.; Hulme, P.; Williams, D.; Reeve, J.","year":"1981","unstructured":"Hesp R, Hulme P, Williams D, Reeve J. The relationship between changes in femoral bone density and calcium balance in patients with involutional osteoporosis treated with human parathyroid hormone fragment (hPTH 1-34). Metabolic Bone Disease and Related Research 1981;2:331-4.","journal-title":"Metabolic Bone Disease and Related Research"},{"key":"ref_7","first-page":"451","article-title":"Treatment of spinal osteoporosis in postmenopausal women","volume":"280","author":"Nordin, B.E.C.; Horsman, A.; Crilly, R.G.; Marshall, D.H.; Simpson, M.","year":"1980","unstructured":"Nordin BEC, Horsman A, Crilly RG, Marshall DH, Simpson M. Treatment of spinal osteoporosis in postmenopausal women. BrMedj 1980;280:451-4.","journal-title":"BrMedj"},{"key":"ref_8","first-page":"347","article-title":"Long-term effect of nandrolone decanoate, lct-hydroxyvitamin D3 or intermittent calcium infusion therapy on bone mineral content, bone remodeling and fracture rate in symptomatic osteoporosis: a double-blind controlled study","volume":"1","author":"Guesens, P.; Dequeker, J.","year":"1986","unstructured":"Guesens P, Dequeker J. Long-term effect of nandrolone decanoate, lct-hydroxyvitamin D3 or intermittent calcium infusion therapy on bone mineral content, bone remodeling and fracture rate in symptomatic osteoporosis: a double-blind controlled study. Bone and Mineral 1986;1:347-57.","journal-title":"Bone and Mineral"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2362.1987.tb01137.x","article-title":"Periodic courses of human 1-34 parathyroid peptide alternating with calcitriol paradoxically reduce bone remodelling in spinal osteoporosis","volume":"17","author":"Reeve, J.; Arlot, M.; Price, T.R.","year":"1987","unstructured":"Reeve J, Arlot M, Price TR, et al. Periodic courses of human 1-34 parathyroid peptide alternating with calcitriol paradoxically reduce bone remodelling in spinal osteoporosis. 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Calcif Tiss nt 1989;44:176-80.","journal-title":"Calcif Tiss nt"},{"key":"ref_16","first-page":"621","article-title":"Parathyroid peptide (hPTH 1-34) in the treatment of osteoporosis","volume-title":"Clinical disorders of bone and mineral metabolism","author":"Reeve, J.; Davies, U.M.; Arlot, M.","year":"1989","unstructured":"Reeve J, Davies UM, Arlot M, et al. Parathyroid peptide (hPTH 1-34) in the treatment of osteoporosis. In: Kleerekoper M, Krane SM, eds. Clinical disorders of bone and mineral metabolism. New York: Liebert, 1989:621-8."},{"key":"ref_17","first-page":"147","article-title":"Osteoporosis and the replacement of cell populations of the marrow by adipose tissue","volume":"80","author":"Meunier, P.J.; Aaron, J.E.; Edouard, C.; Vignon, C.","year":"1970","unstructured":"Meunier PJ, Aaron JE, Edouard C, Vignon C. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. Clin Orthop 1970;80: 147-54.","journal-title":"Clin Orthop"},{"key":"ref_18","first-page":"802","article-title":"Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis","volume":"322","author":"Riggs, B.L.; Hodgson, S.F.; O'Fallon, W.M.","year":"1990","unstructured":"Riggs BL, Hodgson SF, O'Fallon WM, et al. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N EnglJ7 Med 1990;322:802-9."},{"key":"ref_19","first-page":"37","article-title":"Fluoride therapy for osteoporosis promotes a progressive increase in spinal bone density","volume":"5","author":"Farley, S.M.G.; Libanati, C.R.; Mariano-Menez, M.R.; Tudtud-Hans, L.A.; Schulz, E.E.; Baylink, D.J.","year":"1990","unstructured":"Farley SMG, Libanati CR, Mariano-Menez MR, Tudtud-Hans LA, Schulz EE, Baylink DJ. Fluoride therapy for osteoporosis promotes a progressive increase in spinal bone density. journal of Bone and Mineral Research 1990;5:S37-42.","journal-title":"journal of Bone and Mineral Research"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/8756-3282(89)90004-5","article-title":"Skeletal fluorosis: histomorphometric analysis of bone changes and bone fluoride content in 29 patients","volume":"10","author":"Boivin, G.; Chavassieux, P.; Chapuy, M.C.; Baud, C.A.; Pi, Meunier","year":"1989","unstructured":"Boivin G, Chavassieux P, Chapuy MC, Baud CA, Meunier Pi. Skeletal fluorosis: histomorphometric analysis of bone changes and bone fluoride content in 29 patients. Bone 1989;10:89-99.","journal-title":"Bone"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0002-9343(86)90808-9","article-title":"Mechanism of acute lower extremity pain syndrome in fluoride-treated osteoporotic patients","volume":"80","author":"O'Duffy, D.; Wahner, H.W.; O'Fallon, W.M.","year":"1986","unstructured":"O'Duffy D, Wahner HW, O'Fallon WM, et al. Mechanism of acute lower extremity pain syndrome in fluoride-treated osteoporotic patients. Am J Med 1986;80:561-6.","journal-title":"Am J Med"},{"key":"ref_22","first-page":"629","article-title":"Stress fractures in fluoride therapy for osteoporosis","volume":"2","author":"Schnitzler, C.M.","year":"1984","unstructured":"Schnitzler CM. Stress fractures in fluoride therapy for osteoporosis. In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL, eds. Osteoporosis. Vol 2. Aalborg: Stiftsbogtrykkeri, 1984:629-34."},{"key":"ref_23","first-page":"376","article-title":"Continuous sodium fluoride therapy does not reduce vertebral fracture rate in postmenopausal osteoporosis","volume":"4","author":"Kleerekoper, M.; Peterson, E.; Phillips, E.; Nelson, D.; Tilley, B.; Parfitt, A.M.","year":"1989","unstructured":"Kleerekoper M, Peterson E, Phillips E, Nelson D, Tilley B, Parfitt AM. Continuous sodium fluoride therapy does not reduce vertebral fracture rate in postmenopausal osteoporosis. Journal of Bone and Mineral Research 1989;4:S376.","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(88)92834-6","article-title":"Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis","volume":"ii:","author":"Mamelle, N.; Meunier, P.J.; Dusan, R.","year":"1988","unstructured":"Mamelle N, Meunier PJ, Dusan R, et al. Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis. Lancet 1988;ii:361-5.","journal-title":"Lancet"},{"key":"ref_25","first-page":"1","article-title":"A perspective on fluoride and the treatment of osteoporosis","volume":"5","author":"Murray, T.M.","year":"1990","unstructured":"Murray TM. A perspective on fluoride and the treatment of osteoporosis. J'ournal ofBone and Mineral Research 1990;5:S1-4.","journal-title":"J'ournal ofBone and Mineral Research"},{"key":"ref_26","first-page":"177","article-title":"Effects of fluoride treatment on bone strength. J7ournal ofBone and Mineral","volume":"5","author":"Carter, D.R.; Beaupre, G.S.","year":"1990","unstructured":"Carter DR, Beaupre GS. Effects of fluoride treatment on bone strength. J7ournal ofBone and Mineral Research 1990;5:S177-84.","journal-title":"Research"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.301.6747.314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.301.6747.314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T22:55:28Z","timestamp":1765493728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.301.6747.314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8,11]]},"references-count":26,"journal-issue":{"issue":"6747","published-online":{"date-parts":[[1990,8,11]]},"published-print":{"date-parts":[[1990,8,11]]}},"alternative-id":["10.1136\/bmj.301.6747.314"],"URL":"https:\/\/doi.org\/10.1136\/bmj.301.6747.314","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1990,8,11]]}}}