{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:38:52Z","timestamp":1770975532777,"version":"3.50.1"},"reference-count":8,"publisher":"BMJ","issue":"6852","license":[{"start":{"date-parts":[[1992,8,29]],"date-time":"1992-08-29T00:00:00Z","timestamp":715046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1992,8,29]]},"abstract":"<jats:p>OBJECTIVE--To determine whether one week's drug treatment is sufficient to eradicate Helicobacter pylori in patients with duodenal ulcer. DESIGN--Single blind, randomised controlled trial. SETTING--Specialised ulcer clinic in a teaching hospital. PATIENTS--155 patients with H pylori and a duodenal ulcer verified endoscopically which had either bled within the previous 24 hours or was causing dyspepsia. INTERVENTIONS--Patients were allocated randomly to receive either omeprazole for four weeks plus bismuth 120 mg, tetracycline 500 mg, and metronidazole 400 mg (all four times a day) for the first week (n = 78), or omeprazole alone for four weeks (n = 77). Further endoscopy was performed four weeks after cessation of all drugs. MAIN OUTCOME MEASURES--Presence or absence of H pylori (by urease testing, microscopy, and culture of antral biopsy specimens), duodenal ulcer, and side effects. RESULTS--Eradication of H pylori occurred in 70 (95%) patients taking the four drugs (95% confidence interval 86% to 97%) compared with three (4%) patients taking omeprazole alone (1% to 11%). Duodenal ulcers were found in four (5%) patients taking the four drugs (2% to 12%) and in 16 (22%) patients taking omeprazole alone (14% to 32%). Mild dizziness was the only reported side effect (six patients in each group) and did not affect compliance. CONCLUSIONS--A one week regimen of bismuth, tetracycline, and metronidazole is safe and effective in eradicating H pylori and reduces the number of duodenal ulcers four weeks after completing treatment.<\/jats:p>","DOI":"10.1136\/bmj.305.6852.502","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"502-504","source":"Crossref","is-referenced-by-count":95,"title":["Randomised controlled trial of short term treatment to eradicate Helicobacter pylori in patients with duodenal ulcer."],"prefix":"10.1136","volume":"305","author":[{"given":"S. W.","family":"Hosking","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Y.","family":"Yung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,8,29]]},"reference":[{"issue":"109-1","key":"ref_1","first-page":"1","article-title":"Campylobacter pylori and recurrence of duodenal","volume":"1","author":"Coghlan, J.G.; Gilligan, D.; Humphries, H.; McKenna, D.; Doolley, C.; Sweeney, E.","year":"1987","unstructured":"Coghlan JG, Gilligan D, Humphries H, McKenna D, Doolley C, Sweeney E, et al. Campylobacter pylori and recurrence of duodenal ulcers-a 12 month follow up study. Lancet 1987;ii: 1 109-1 1.","journal-title":"Lancet; study"},{"key":"ref_2","first-page":"1437","article-title":"Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori","volume":"ii:","author":"Marshall, B.J.; Goodwin, C.S.; Warren, JR, Murray; R, Blincow; ED, Blackbourn; S.J.","year":"1988","unstructured":"Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 1988;ii: 1437-41.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(90)91301-P","article-title":"Eradication of H pylori cures duodenal ulcer","volume":"335","author":"Rauws, E.A.J.; Tytgat, G.N.J.","year":"1990","unstructured":"Rauws EAJ, Tytgat GNJ. Eradication of H pylori cures duodenal ulcer. Lancet 1990;335: 1233-5.","journal-title":"Lancet"},{"key":"ref_4","first-page":"131","article-title":"Helicobacter pylori therapy: effect on peptic ulcer disease. In: Working party report to the World Congress of Gastroenterology, Sydney 1990. Helicobacter pylori: causal agent in peptic ulcer disease? A working team report","volume-title":"journal of Gastroenterology and Hepatology 1991","volume":"6","author":"Axon, A.T.R.","unstructured":"Axon ATR. Helicobacter pylori therapy: effect on peptic ulcer disease. In: Working party report to the World Congress of Gastroenterology, Sydney 1990. Helicobacter pylori: causal agent in peptic ulcer disease? A working team report. journal of Gastroenterology and Hepatology 1991;6: 131-7."},{"key":"ref_5","first-page":"24","article-title":"Is doxycycline more effective than tetracycline HCI in triple therapy of Helicobacter pylori?","volume":"98","author":"Borody, T.; Lenne, J.; Moore-Jones, D.; Devine, M.; Walton, M.; George, L.","year":"1990","unstructured":"Borody T, Lenne J, Moore-Jones D, Devine M, Walton M, George L. Is doxycycline more effective than tetracycline HCI in triple therapy of Helicobacter pylori? (abstract) Gastroenterology 1990;98:A24.","journal-title":"(abstract) Gastroenterology"},{"issue":"1","key":"ref_6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000200519","article-title":"The clinical safety of omeprazole","volume":"47","author":"Solvell, L.","year":"1990","unstructured":"Solvell L. The clinical safety of omeprazole. Digestion 1990;47 (suppl 1):59-63.","journal-title":"Digestion"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/0140-6736(91)92111-E","article-title":"A one week eradication regime for Helicobacter pylorn","volume":"338","author":"Logan, R.P.H.; Gummett, P.A.; Misiewicz, J.J.; Karim, Q.N.; Walker, M.M.; Baron, J.H.","year":"1991","unstructured":"Logan RPH, Gummett PA, Misiewicz JJ, Karim QN, Walker MM, Baron JH. A one week eradication regime for Helicobacter pylorn. Lancet 1991;338: 1249-52.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000199597","article-title":"High incidence of Campylobacter-like organisms in endoscopic biopsies from patients with gastritis, with or without peptic ulcer","volume":"38","author":"Fiocca, R.; Villani, L.; Jurpini, F.; Turpini, R.; Olcia, S.; E.","year":"1987","unstructured":"Fiocca R, Villani L, Jurpini F, Turpini R, S Olcia E. High incidence of Campylobacter-like organisms in endoscopic biopsies from patients with gastritis, with or without peptic ulcer. Digestion 1987;38:234-44.","journal-title":"Digestion"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.305.6852.502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.305.6852.502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T16:25:04Z","timestamp":1766334304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.305.6852.502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8,29]]},"references-count":8,"journal-issue":{"issue":"6852","published-online":{"date-parts":[[1992,8,29]]},"published-print":{"date-parts":[[1992,8,29]]}},"alternative-id":["10.1136\/bmj.305.6852.502"],"URL":"https:\/\/doi.org\/10.1136\/bmj.305.6852.502","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,8,29]]}}}