{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:28:03Z","timestamp":1791898083654,"version":"4.3.4"},"reference-count":12,"publisher":"BMJ","issue":"6853","license":[{"start":{"date-parts":[[1992,9,5]],"date-time":"1992-09-05T00:00:00Z","timestamp":715651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1992,9,5]]},"abstract":"<jats:p>OBJECTIVES--(a) to determine the efficacy of papaveretum in treating pain when administered early to patients presenting with acute abdominal pain and (b) to assess its effect on subsequent diagnosis and management. DESIGN--Prospective, randomised, placebo controlled study. SETTING--Walsgrave Hospital, Coventry. SUBJECTS--100 consecutive patients with clinically significant abdominal pain who were admitted as emergencies to a surgical firm. INTERVENTIONS--Intramuscular injection of up to 20 mg papaveretum or an equivalent volume of saline. OUTCOME MEASURES--Pain and tenderness scores, assessment of patient comfort, accuracy of diagnosis, and management decisions. RESULTS--Median pain and tenderness scores were lower after papaveretum (pain score 8.3 in control group and 3.1 in treatment group, p &lt; 0.0001; tenderness score 8.1 in control group and 5.1 in treatment group, p &lt; 0.0001). Forty eight patients were deemed to be comfortable after papaveretum compared with nine after saline. Incorrect diagnoses and management decisions applied to two patients after papaveretum compared with nine patients after saline. CONCLUSION--Early administration of opiate analgesia to patients with acute abdominal pain can greatly reduce their pain. This does not interfere with diagnosis, which may even be facilitated despite a reduction in the severity of physical signs. These patients should not be denied effective treatment.<\/jats:p>","DOI":"10.1136\/bmj.305.6853.554","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"554-556","source":"Crossref","is-referenced-by-count":150,"title":["Safety of early pain relief for acute abdominal pain."],"prefix":"10.1136","volume":"305","author":[{"given":"A. R.","family":"Attard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Corlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Kidner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. A.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,9,5]]},"reference":[{"key":"ref_1","article-title":"Early diagnosis ofthe acute abdomen","author":"Cope, Z.","year":"1979","unstructured":"Cope Z. Early diagnosis ofthe acute abdomen. 15th ed, revised by Silen W. New York: Oxford University Press, 1979.","edition":"15th ed"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/bmj.2.6200.1289","article-title":"Analgesia and the acute abdomen","volume":"ii:","author":"Lavelle, M.","year":"1979","unstructured":"Lavelle M. Analgesia and the acute abdomen. BMJ 1979;ii: 1289.","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/bmj.2.6200.1289-a","article-title":"Analgesia and the acute abdomen","volume":"ii:","author":"Shepherd, J.","year":"1979","unstructured":"Shepherd J. Analgesia and the acute abdomen. BMJ 1979;ii: 1289.","journal-title":"BMJ"},{"key":"ref_4","first-page":"1289","article-title":"Analgesia and the acute abdomen. B","volume":"ii:","author":"Dudley, H.","year":"1979","unstructured":"Dudley H. Analgesia and the acute abdomen. B.MJf 1979;ii: 1289-90.","journal-title":"MJf"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1136\/bmj.2.6200.1290","article-title":"Analgesia and the acute abdomen","volume":"ii:","author":"Quayle, J.","year":"1979","unstructured":"Quayle J. Analgesia and the acute abdomen. BMJ 1979;ii: 1290.","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/bmj.2.6201.1363-a","article-title":"Analgesia and the acute abdomen","volume":"ii:","author":"Hamilton, W.A.P.","year":"1979","unstructured":"Hamilton WAP. Analgesia and the acute abdomen. BMJ 1979;ii: 1363.","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/bmj.2.6201.1363-b","article-title":"Analgesia and the acute abdomen","volume":"ii:","author":"Fraser, I.D.","year":"1979","unstructured":"Fraser ID. Analgesia and the acute abdomen. BMJ 1979;ii: 1363.","journal-title":"BMJ"},{"key":"ref_8","article-title":"Analgesia and the acute abdomen","author":"Piper, J.V.","year":"1979","unstructured":"Piper JV. Analgesia and the acute abdomen. BMJ 1979;ii: 1443.","journal-title":"BMJ"},{"key":"ref_9","article-title":"The acute abdomen and disorders of the peritoneal cavity","volume-title":"Essential surgical practice","author":"Cuschieri, A.","unstructured":"Cuschieri A. The acute abdomen and disorders of the peritoneal cavity. In: Cuschieri A, Giles GR, Moossa AR, eds. Essential surgical practice. 2nd ed. London: Wright PSG, 1986:1238.","edition":"2nd ed"},{"key":"ref_10","article-title":"The acute abdomen","volume-title":"Current surgical diagnosis and treatment","author":"Boey, J.H.","unstructured":"Boey JH. The acute abdomen. In: Way LW, ed. Current surgical diagnosis and treatment. Connecticut: Prentice Hall, 1991:440."},{"key":"ref_11","first-page":"209","article-title":"Analgesia in the acute abdomen","volume":"68","author":"Zoltie, N.; Cust, M.P.","year":"1986","unstructured":"Zoltie N, Cust MP. Analgesia in the acute abdomen. Ann Roy Coll Surg 1986;68:209-10."},{"key":"ref_12","article-title":"Committee on Safety of Medicines. Genotoxicity of papaveretum and noscapine","volume":"31","year":"1991","unstructured":"Committee on Safety of Medicines. Genotoxicity of papaveretum and noscapine. Current Problems 1991;No 31.","journal-title":"Current Problems"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.305.6853.554","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.305.6853.554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T16:30:33Z","timestamp":1766334633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.305.6853.554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,5]]},"references-count":12,"journal-issue":{"issue":"6853","published-online":{"date-parts":[[1992,9,5]]},"published-print":{"date-parts":[[1992,9,5]]}},"alternative-id":["10.1136\/bmj.305.6853.554"],"URL":"https:\/\/doi.org\/10.1136\/bmj.305.6853.554","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9,5]]}}}