{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:03:33Z","timestamp":1777392213312,"version":"3.51.4"},"reference-count":7,"publisher":"BMJ","issue":"6857","license":[{"start":{"date-parts":[[1992,10,3]],"date-time":"1992-10-03T00:00:00Z","timestamp":718070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1992,10,3]]},"abstract":"<jats:p>OBJECTIVE--(a) To determine whether children given chemotherapy for haematological malignancy have significantly more melanocytic naevi than age matched children in the local population; (b) to establish whether any observed variation in naevus counts from normal is seen at the start of maintenance chemotherapy. DESIGN--Follow up of 29 consecutive children starting maintenance chemotherapy, with parental interview and count of all melanocytic naevi &gt; or = 2 mm on the child's skin. Assessment repeated three years later after completion of maintenance chemotherapy. Other dermatological problems identified at either visit were also recorded. SETTING--Royal Hospital for Sick Children, Glasgow. RESULTS--At the start of maintenance chemotherapy all children had total body counts of melanocytic naevi within the normal range established for age matched children in the local population. Three years later total body naevus counts were significantly increased, the median increase being 66 naevi per child (95% confidence interval 57 to 94). The only other problem noted in these children was relatively poor regrowth of scalp hair. CONCLUSION--Children on maintenance chemotherapy for haematological malignancies develop an excessive number of melanocytic naevi. Excessive numbers of melanocytic naevi are the most important risk factor for melanoma in the general population. These children should have periodic skin examinations at their follow up visits, and both child and parent should be educated about clinical features of early melanoma.<\/jats:p>","DOI":"10.1136\/bmj.305.6857.799","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"799-801","source":"Crossref","is-referenced-by-count":41,"title":["Effect of maintenance chemotherapy in childhood on numbers of melanocytic naevi."],"prefix":"10.1136","volume":"305","author":[{"given":"E. A.","family":"Baird","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"McHenry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"MacKie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/mpo.2950180417","article-title":"Prevalence of naevocytic naevi after chemotherapy for childhood cancer","volume":"18","author":"de Wit PE; de Vaan GA; de Boo TM; WA, Lemmens; FH, Rampen","year":"1990","unstructured":"de Wit PE, de Vaan GA, de Boo TM, Lemmens WA, Rampen FH. Prevalence of naevocytic naevi after chemotherapy for childhood cancer. Med Pediatr Oncol 1990;18:336-8.","journal-title":"Med Pediatr Oncol"},{"key":"ref_2","first-page":"167","article-title":"The number and distribution of benign pigmented moles (melanocytic naevi) in a healthy British population","volume":"113","author":"MacKie, R.M.; English, J.; Aitchison, T.C.; Fitzsimons, C.P.; Wilson, P.D.","year":"1985","unstructured":"MacKie RM, English J, Aitchison TC, Fitzsimons CP, Wilson PD. The number and distribution of benign pigmented moles (melanocytic naevi) in a healthy British population. BrJ7 Dermatol 1985;113:167-74."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1001\/archderm.1990.01670300070010","article-title":"and pigmentation factors and the frequency of acquired melanocytic nevi in children","volume":"126","author":"Gallagher, R.P.; McLean, D.I.; Yang, C.P.; Coldman, A.J.; Silver, H.K.B.; Spinelli, J.J.","year":"1990","unstructured":"Gallagher RP, McLean DI, Yang CP, Coldman AJ, Silver HKB, Spinelli JJ, et al. Suntan, sunburn, and pigmentation factors and the frequency of acquired melanocytic nevi in children. Arch Dermatol 1990;126:770-6.","journal-title":"Arch Dermatol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1136\/bmj.292.6535.1555","article-title":"Benign melanocytic naevi as a risk factor for malignant melanoma","volume":"292","author":"Swerdlow, A.J.; English, J.S.C.; MacKie, R.M.; O'Doherty, C.J.; Hunter, J.A.A.; Clark, J.","year":"1986","unstructured":"Swerdlow AJ, English JSC, MacKie RM, O'Doherty CJ, Hunter JAA, Clark J, et al. Benign melanocytic naevi as a risk factor for malignant melanoma. BMJ 1986;292: 1555-9.","journal-title":"BMJ"},{"key":"ref_5","first-page":"200","article-title":"The Danish case-control study of cutaneous malignant melanoma","volume":"42","author":"Osterlind, A.; Tucker, M.A.; Hou-Jensen, K.; Stone, B.J.; Engholm, G.; Jensen, O.M.","year":"1988","unstructured":"Osterlind A, Tucker MA, Hou-Jensen K, Stone BJ, Engholm G, Jensen OM. The Danish case-control study of cutaneous malignant melanoma. I. Importance of host factors. Int3 Cancer 1988;42:200-6.","journal-title":"I. Importance of host factors. Int3 Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0190-9622(87)70230-8","article-title":"Number of melanocytic nevi as a major risk factor for malignant melanoma","volume":"17","author":"Holly, E.A.; Kelly, J.W.; Shpall, S.; Chiu, S.-H.","year":"1987","unstructured":"Holly EA, Kelly JW, Shpall S, Chiu S-H. Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol 1987;17: 459-68.","journal-title":"J Am Acad Dermatol"},{"key":"ref_7","first-page":"487","article-title":"Personal risk-factor chart for cutaneous melanoma","volume":"ii:","author":"MacKie, R.M.; Freudenberger, T.; Aitchison, T.","year":"1989","unstructured":"MacKie RM, Freudenberger T, Aitchison T. Personal risk-factor chart for cutaneous melanoma. Lancet 1989;ii:487-90.","journal-title":"Lancet"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.305.6857.799","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.305.6857.799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T05:02:27Z","timestamp":1766379747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.305.6857.799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,3]]},"references-count":7,"journal-issue":{"issue":"6857","published-online":{"date-parts":[[1992,10,3]]},"published-print":{"date-parts":[[1992,10,3]]}},"alternative-id":["10.1136\/bmj.305.6857.799"],"URL":"https:\/\/doi.org\/10.1136\/bmj.305.6857.799","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10,3]]}}}