{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:42:13Z","timestamp":1790127733513,"version":"4.0.1"},"reference-count":12,"publisher":"BMJ","issue":"6859","license":[{"start":{"date-parts":[[1992,10,17]],"date-time":"1992-10-17T00:00:00Z","timestamp":719280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1992,10,17]]},"abstract":"<jats:p>OBJECTIVE--To evaluate the contribution of specific nutritional deficiencies (as indicated by zinc; vitamin A, C, and E; albumin; and haemoglobin concentrations) to the risk of pressure sores. DESIGN--Observational cohort study. SETTING--St James's University Hospital, Leeds. SUBJECTS--21 elderly patients presenting consecutively to the orthopaedic unit with femoral neck fracture. MAIN OUTCOME MEASURE--Full thickness epidermal break over a pressure bearing surface. RESULTS--10 patients (48%) developed a pressure sore during their hospital stay. Indices of zinc status and concentrations of albumin, haemoglobin, and vitamins A and E were similar in patients who developed a pressure sore and those who did not. Mean leucocyte vitamin C concentration, however, was 6.3 (SD 2.2) micrograms\/10(8) cells in patients who developed a pressure sore as compared with 12.8 (4.6) micrograms\/10(8) cells in patients who did not. CONCLUSIONS--Low concentrations of leucocyte vitamin C appear to be associated with subsequent development of pressure sores in elderly patients with femoral neck fractures.<\/jats:p>","DOI":"10.1136\/bmj.305.6859.925","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"925-927","source":"Crossref","is-referenced-by-count":64,"title":["Vitamin C depletion and pressure sores in elderly patients with femoral neck fracture."],"prefix":"10.1136","volume":"305","author":[{"given":"H. F.","family":"Goode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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Anltmicrtsh Agents C,hemother 1990;34:906-8.","journal-title":"jInt,'tViDii; Ini vitro tumor necrosis factor iicdtiction assaf'or analysis of febrile toxicitv associated with amphotericin B preparations"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/infdis\/156.5.784","article-title":"Induction of prostaglandin svnthesis as the mechanism responsible for chills and fever produced by infuision of amphotericin B","volume":"156","author":"Gigliotti, F.; Shenep, J.; Lott, L.; Thornton, D.","year":"1987","unstructured":"Gigliotti F, Shenep J, Lott L, Thornton D. Induction of prostaglandin svnthesis as the mechanism responsible for chills and fever produced by infuision of amphotericin B. J Infect Dis 1987;156:784-9.","journal-title":"J Infect Dis"},{"key":"ref_6","first-page":"257","article-title":"How do the polyene macrolide antibiotics affect the cellular membrane properties?","volume":"864","author":"Bolard, J.","year":"1986","unstructured":"Bolard J. How do the polyene macrolide antibiotics affect the cellular membrane properties? Biochem Biophys Acta 1986;864:257-304.","journal-title":"Biochem Biophys Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1128\/AAC.34.2.183","article-title":"Amphotericin B: currelnt understanding of mechanisms of action","volume":"34","author":"Brajtburg, J.; Powderly, W.; Kobayashi, G.; Medoff, G.","year":"1990","unstructured":"Brajtburg J, Powderly W, Kobayashi G, Medoff G. Amphotericin B: currelnt understanding of mechanisms of action. Antimicrob Agents Chemother 1990;34: 183-8.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_8","first-page":"6122","article-title":"Unusual lipid structures","volume-title":"selectively reduce the Proc NatlAcadSci USA 1988","volume":"85","author":"Janoff, A.; Boni, L.; Popescu, M.; Minche, SR, Cullis; PR, Madden; T.D.","unstructured":"Janoff A, Boni L, Popescu M, Minche SR, Cullis PR, Madden TD, et al. 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Simultaneous determination of retinol and (ttocopherol in serum or plasma by liquid chromatography. Clin Chemn Department of Medical Statistics, University 1983;29:708-12."},{"issue":"21","key":"ref_12","first-page":"157","article-title":"The determination of ascorbic acid in white blood cells","volume":"1961","author":"Denson, K.W.; Bowers, E.F.","unstructured":"Denson KW, Bowers EF. The determination of ascorbic acid in white blood cells. 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