{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:23:41Z","timestamp":1789993421240,"version":"4.0.1"},"reference-count":7,"publisher":"BMJ","issue":"6859","license":[{"start":{"date-parts":[[1992,10,17]],"date-time":"1992-10-17T00:00:00Z","timestamp":719280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1992,10,17]]},"abstract":"<jats:p>OBJECTIVE--To compare the effectiveness and acceptability of three regimens of postcoital contraception. DESIGN--Randomised group comparison of ethinyloestradiol 100 micrograms plus levonorgestrel 500 micrograms repeated after 12 hours (Yuzpe method); danazol 600 mg repeated after 12 hours; and mifepristone 600 mg single dose. SETTING--Community family planning clinic. SUBJECTS--616 consecutive women with regular cycles aged 16 to 45 years. MAIN OUTCOME MEASURES--Number of pregnancies, incidence of side effects, and timing of next period. RESULTS--The raw pregnancy rates (with 95% confidence intervals) for the Yuzpe, danazol, and mifepristone groups were 2.62% (0.86% to 6.00%), 4.66% (2.15% to 8.67%), and 0% (0% to 1.87%) respectively. Overall, these rates differed significantly (chi 2 = 8.988, df = 2; p = 0.011). The differences between the mifepristone and Yuzpe groups and between the mifepristone and danazol groups were also significant. Side effects were more common and more severe in the Yuzpe group (133 women (70%)) than in either the danazol group (58 (30%)) or the mifepristone group (72 (37%)). The Yuzpe regimen tended to induce bleeding early but mifepristone prolonged the cycle. Three women bled more than seven days late in the Yuzpe group compared with 49 in the mifepristone group. CONCLUSIONS--Mifepristone was effective in reducing expected pregnancy rates and the Yuzpe method also had a clinical effect. Danazol had little or no effect. A further multicentre trial is needed.<\/jats:p>","DOI":"10.1136\/bmj.305.6859.927","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"927-931","source":"Crossref","is-referenced-by-count":166,"title":["Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception."],"prefix":"10.1136","volume":"305","author":[{"given":"A. M.","family":"Webb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,10,17]]},"reference":[{"key":"ref_1","first-page":"\"9LJ\" # \"247","article-title":"Cellular and muscle zinc to surgical patients with and without gastrointestinal cancer","volume":"20","author":"Goode, H.F.; Kelleher, J.; Walker, B.E.; Hall, R.I.; Guillou, P.J.","year":"1990","unstructured":"Goode HF, Kelleher J, Walker BE, Hall RI, Guillou PJ. Cellular and muscle zinc to surgical patients with and without gastrointestinal cancer. Clin Sci Centre, Manchester M20 9LJ Anne M C Webb, clinical 1990;79:247-52.","journal-title":"Clin Sci Centre, Manchester; Anne M C Webb, clinical"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/000456328902600114","article-title":"Zinc concentrations in pure populations of peripheral blood neutrophils, lymphocytes and monocytes","volume":"26","author":"Goode, H.F.; Kelleher, J.; Walker, B.E.","year":"1989","unstructured":"Goode HF, Kelleher J, Walker BE. Zinc concentrations in pure populations of peripheral blood neutrophils, lymphocytes and monocytes. Ann Clin Biochemn 1989;26:89-95. research fellow","journal-title":"Ann Clin Biochemn"},{"key":"ref_3","first-page":"708","article-title":"Simultaneous determination of retinol and (ttocopherol in serum or plasma by liquid chromatography","volume-title":"Clin","volume":"29","author":"Catignami, G.L.; Bieri, J.G.","year":"1983","unstructured":"Catignami GL, Bieri JG. Simultaneous determination of retinol and (ttocopherol in serum or plasma by liquid chromatography. Clin Chemn Department of Medical Statistics, University 1983;29:708-12."},{"issue":"21","key":"ref_4","first-page":"157","article-title":"The determination of ascorbic acid in white blood cells","volume":"1961","author":"Denson, K.W.; Bowers, E.F.","unstructured":"Denson KW, Bowers EF. The determination of ascorbic acid in white blood cells. Clin Sci 1961;21:157-62.","journal-title":"Clin Sci"},{"key":"ref_5","first-page":"375","article-title":"Interception: post-coital esbtrroognencshion d30i1l6awtoomren.inCoantsratchepmtiao.n Patients have been reported","volume":"14","author":"Haspels, A.A.","year":"1976","unstructured":"Haspels AA. Interception: post-coital esbtrroognencshion d30i1l6awtoomren.inCoantsratchepmtiao.n Patients have been reported 1976;14:375-81."},{"key":"ref_6","first-page":"39","article-title":"Handbook of contraceptive practice","volume":"27","author":"J, Bou1n7ds O.W.C.","year":"1983","unstructured":"Department of Health. Handbook of contraceptive practice. London: DoH, B11MRJow1l99a0n.VdsOLS,UGMuiElle3b0au5d J, Bou1n7ds OWC,TBOoBotEhRM.19Si9d2e effects of danazol compared with an ethinylestradiol\/norgestrel combination when used for postcoital contraception. Contraception 1983;27:39-49.","journal-title":"Contraception; TBOoBotEhRM.19Si9d2e effects of danazol compared with an ethinylestradiol\/norgestrel combination when used for postcoital contraception"},{"key":"ref_7","first-page":"253","article-title":"Hormonal postcoital contraception with an ethinvlestradiol nogestrel combination and two danazol regimes. Eur_7 Obstet Gynecol Reprod Biol","volume":"37","author":"Zuliani, G.; Colombo, U.F.; Molla, R.","year":"1990","unstructured":"Zuliani G, Colombo UF, Molla R. Hormonal postcoital contraception with an ethinvlestradiol nogestrel combination and two danazol regimes. Eur_7 Obstet Gynecol Reprod Biol 1990;37:253-60."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.305.6859.927","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.305.6859.927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T05:11:03Z","timestamp":1766380263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.305.6859.927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,17]]},"references-count":7,"journal-issue":{"issue":"6859","published-online":{"date-parts":[[1992,10,17]]},"published-print":{"date-parts":[[1992,10,17]]}},"alternative-id":["10.1136\/bmj.305.6859.927"],"URL":"https:\/\/doi.org\/10.1136\/bmj.305.6859.927","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10,17]]}}}