{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T21:05:20Z","timestamp":1766437520102,"version":"3.48.0"},"reference-count":29,"publisher":"BMJ","issue":"6899","license":[{"start":{"date-parts":[[1993,7,31]],"date-time":"1993-07-31T00:00:00Z","timestamp":744076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1993,7,31]]},"abstract":"<jats:p>OBJECTIVE--To examine the relation between the use of aspirin and non-steroidal anti-inflammatory drugs and the presence of asymptomatic colorectal adenomas. DESIGN--Case-control study of subjects participating in a randomised controlled trial of faecal occult blood screening for colorectal cancer. Data on analgesics and other drugs were obtained from a questionnaire which was mainly concerned with diet and was administered by an interviewer. SETTING--Nottingham. SUBJECTS--147 patients with positive results in faecal occult blood tests who were found to have colorectal adenomas (cases), 153 age and sex matched control subjects with negative results in such tests (negative controls), and 176 control subjects with positive results in the tests who were found not to have colorectal adenomas (positive controls). MAIN OUTCOME MEASURES--Relative risk of developing colorectal adenomas according to frequency and duration of use of analgesics. RESULTS--Cases reported taking less aspirin and non-steroidal anti-inflammatory drugs than the negative controls, with the estimated relative risk for any use being 0.49 (95% confidence interval 0.3 to 0.8). The inverse association was less strong when cases were compared with the positive controls (0.66 (0.4 to 1.1)). The association was specific for aspirin and non-steroidal anti-inflammatory drugs there being no association with paracetamol or other drugs. Prescribed use of non-steroidal anti-inflammatory drugs for longer than five years was associated with the lowest risk (0.21 (0.1 to 0.8)), although the numbers reporting prolonged prescribed use were small. CONCLUSIONS--These findings support the hypothesis that aspirin and non-steroidal anti-inflammatory drug use protects against the development of colorectal neoplasia.<\/jats:p>","DOI":"10.1136\/bmj.307.6899.285","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"285-289","source":"Crossref","is-referenced-by-count":203,"title":["Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme."],"prefix":"10.1136","volume":"307","author":[{"given":"R F","family":"Logan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Hawtin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Hardcastle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,7,31]]},"reference":[{"key":"ref_1","first-page":"1323","article-title":"Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors","volume":"64","author":"Pollard, M.; Luckert, P.H.","year":"1980","unstructured":"Pollard M, Luckert PH. Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors. Cancer Treat Rep 1980;64:1323-7.","journal-title":"Cancer Treat Rep"},{"key":"ref_2","first-page":"57","article-title":"The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat","volume":"21","author":"Pollard, M.; Luckert, P.H.; Schmidt, M.A.","year":"1983","unstructured":"Pollard M, Luckert PH, Schmidt MA. The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat. CancerLeu 1983;21:57-61.","journal-title":"CancerLeu"},{"key":"ref_3","first-page":"1614","article-title":"Treatment of chemically-induced intestinal","volume-title":"cancers with indomethacin. Proc Soc Exp BiolMed","volume":"167","author":"Pollard, M.; Luckert, P.H.","year":"1981","unstructured":"Pollard M, Luckert PH. Treatment of chemically-induced intestinal cancers with indomethacin. 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Cancer Res 1981;41:1954-7.","journal-title":"Cancer Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/carcin\/4.10.1225","article-title":"Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats by non-steroid anti-inflammatory agent indomethacin","volume":"4","author":"Narisawa, T.; Satoh, M.; Sano, M.; Takahashi, T.","year":"1983","unstructured":"Narisawa T, Satoh M, Sano M, Takahashi T. Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats by non-steroid anti-inflammatory agent indomethacin. 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Cancer Res 1987;47:5340-6.","journal-title":"Cancer Res"},{"key":"ref_8","first-page":"2562","article-title":"Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antinflammatory drug with D, L-c-difluoromethylomithine, an ornithine decarboxylase inhibitor, in diet","volume":"50","author":"Reddy, B.S.; Nayini, J.; Tokumo, K.; Rigotty, J.; Zang, E.; Kelloff, G.","year":"1990","unstructured":"Reddy BS, Nayini J, Tokumo K, Rigotty J, Zang E, Kelloff G. Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antinflammatory drug with D,L-c-difluoromethylomithine, an ornithine decarboxylase inhibitor, in diet. Cancer Res 1990;50:2562-8.","journal-title":"Cancer Res"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/BF02553001","article-title":"Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer","volume":"27","author":"Metzger, U.; Meier, J.; Uhlschmid, G.; Weihe, H.","year":"1984","unstructured":"Metzger U, Meier J, Uhlschmid G, Weihe H. Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer. Dis Colon Rectum 1984;27:366-9.","journal-title":"Dis Colon Rectum"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jso.2930240119","article-title":"Sulindac for polyposis of the colon","volume":"24","author":"Waddell, W.R.; Loughry, R.W.","year":"1983","unstructured":"Waddell WR, Loughry RW. Sulindac for polyposis of the colon. J Surg Oncol 1983;24:83-7.","journal-title":"J Surg Oncol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0016-5085(91)90519-Q","article-title":"Sulindac causes regression of rectal polyps in familial adenomatous polyposis","volume":"101","author":"Labayle, D.; Fischer, D.; Vielh, P.; Drouhin, F.; Pariente, A.; Bories, C.","year":"1991","unstructured":"Labayle D, Fischer D, Vielh P, Drouhin F, Pariente A, Bories C, et al. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. 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Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer 1988;48:399-404.","journal-title":"Cancer"},{"key":"ref_14","first-page":"355","article-title":"A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large bowel-cancer","volume":"83","author":"Rosenberg, L.; Palmer, JR, Zauber; AG, Warshauer; ME, Stolley; PD, Shapiro; S.","year":"1991","unstructured":"Rosenberg L, Palmer JR, Zauber AG, Warshauer ME, Stolley PD, Shapiro S. A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large bowel-cancer.JNadCancerInst 1991;83:355-8.","journal-title":"JNadCancerInst"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1056\/NEJM199112053252301","article-title":"Aspirin use and reduced risk of colon cancer","volume":"325","author":"Thun, M.J.; Namboodiri, M.M.; Heath, C.W.","year":"1991","unstructured":"Thun MJ, Namboodiri MM, Heath CW. 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Colorectal adenomas and diet: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme. Br J Cancer 1993;67:177-84.","journal-title":"Br J Cancer"},{"key":"ref_18","first-page":"1160","article-title":"Randomised, controlled trial of faecal occult blood screening for colorectal cancer. Results for first 107,349 subjects","volume":"i:","author":"Hardcastle, J.D.; Thomas, W.M.; Chamberlain, J.; Pye, G.; Sheffield, J.; James, P.D.","year":"1989","unstructured":"Hardcastle JD, Thomas WM, Chamberlain J, Pye G, Sheffield J, James PD, et al. Randomised, controlled trial of faecal occult blood screening for colorectal cancer. Results for first 107,349 subjects. Lancet 1989;i: 1160-4.","journal-title":"Lancet"},{"key":"ref_19","article-title":"SEARCH: a computer package for the analysis of case-control studies","author":"Macfarlane, G.J.; Boyle, P.; Maisonneuve, P.","year":"1988","unstructured":"Macfarlane GJ, Boyle P, Maisonneuve P. SEARCH: a computer package for the analysis of case-control studies. Lyons: International Agency for Research on Cancer, 1988."},{"key":"ref_20","first-page":"1","article-title":"GLIM: the generalised linear interactive modeUing system","volume-title":"3.77 Manual and Macro Library Release 1","author":"Baker, R.J.; Clarke, M.R.B.; Nelder, J.A.","year":"1985","unstructured":"Baker RJ, Clarke MRB, Nelder JA. GLIM: the generalised linear interactive modeUing system. Oxford: Numerical Algorithms Group, 1985. (GLIM 3.77 Manual and Macro Library Release 1. 1.)"},{"key":"ref_21","article-title":"EGRET (Epidemiological Graphics, Estimation, and Testing Package)","author":"Statistics; Corporation, Epidemiology Research","year":"1991","unstructured":"Statistics and Epidemiology Research Corporation. EGRET (Epidemiological Graphics, Estimation, and Testing Package). Seattle: SERC, 1991."},{"key":"ref_22","first-page":"799","article-title":"A comparison of an immunological faecal occult blood test Fecatwin sensitive\/ FECA EIA with Haemoccult in population screening for colorectal cancer","volume":"51","author":"Armitage, N.; Hardcastle, J.D.; Amar, S.S.; Balfour, T.W.; Haynes, J.; James, P.D.","year":"1985","unstructured":"Armitage N, Hardcastle JD, Amar SS, Balfour TW, Haynes J, James PD. A comparison of an immunological faecal occult blood test Fecatwin sensitive\/ FECA EIA with Haemoccult in population screening for colorectal cancer. BrJCancer 1985;51:799-804.","journal-title":"BrJCancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0140-6736(80)90452-3","article-title":"Reappraisal of the effects of aspirin on the stomach","volume":"ii:","author":"Rees, W.D.; Turnberg, L.A.","year":"1980","unstructured":"Rees WD, Turnberg LA. Reappraisal of the effects of aspirin on the stomach. Lancet 1980;ii:410-3.","journal-title":"Lancet"},{"key":"ref_24","first-page":"71","article-title":"Bleeding pattems in colorectal cancer: the effect of aspirin and the implications for faecal occult blood testing","volume":"69","author":"Doran, J.; Hardcastle, J.D.","year":"1982","unstructured":"Doran J, Hardcastle JD. Bleeding pattems in colorectal cancer: the effect of aspirin and the implications for faecal occult blood testing. Br J Surg 1982;69:71 1-3.","journal-title":"Br J Surg"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00004836-198304000-00006","article-title":"1,300 mg of aspirin daily does not cause positive fecal Hemoccult tests","volume":"5","author":"Norfleet, R.G.","year":"1983","unstructured":"Norfleet RG. 1,300 mg of aspirin daily does not cause positive fecal Hemoccult tests.JClin Gastroenterol 1983;5:123-5.","journal-title":"JClin Gastroenterol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1136\/gut.31.11.1294","article-title":"Role of upper gastrointestinal investigations in a screening study for colorectal neoplasia","volume":"31","author":"Thomas, W.M.; Hardcastle, J.D.","year":"1990","unstructured":"Thomas WM, Hardcastle JD. Role of upper gastrointestinal investigations in a screening study for colorectal neoplasia. Gut 1990;31:1294-7.","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/jama.1990.03450010080035","article-title":"Small adenomas detected during fecal occult blood test screening for colorectal cancer: the impact of serendipity","volume":"264","author":"Ransohoff, D.F.; Lang, C.A.","year":"1990","unstructured":"Ransohoff DF, Lang CA. Small adenomas detected during fecal occult blood test screening for colorectal cancer: the impact of serendipity. JAMA 1990;264:76-8.","journal-title":"JAMA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/bmj.294.6586.1510","article-title":"Influence of nonsteroidal anti-inflammatory drugs on the outcome of faecal occult blood tests in screening for colorectal cancer","volume":"294","author":"Pye, G.; Ballantyne, K.C.; Armitage, N.C.; Hardcastie, J.D.","year":"1987","unstructured":"Pye G, Ballantyne KC, Armitage NC, Hardcastie JD. Influence of nonsteroidal anti-inflammatory drugs on the outcome of faecal occult blood tests in screening for colorectal cancer. BMJ 1987;294:1510-1.","journal-title":"BMJ"},{"key":"ref_29","first-page":"1054","article-title":"16,16-Dimethyl prostaglandin E2 suppresses the increases in the proliferative activity of rat colonic epithelium induced by","volume-title":"indomethacin and aspirin. Gastroenterology 1985; 89","author":"DeRubertis, F.R.; Craven, P.A.; Saito, R.","unstructured":"DeRubertis FR, Craven PA, Saito R. 16,16-Dimethyl prostaglandin E2 suppresses the increases in the proliferative activity of rat colonic epithelium induced by indomethacin and aspirin. 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