{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T21:05:22Z","timestamp":1766437522646,"version":"3.48.0"},"reference-count":17,"publisher":"BMJ","issue":"6899","license":[{"start":{"date-parts":[[1993,7,31]],"date-time":"1993-07-31T00:00:00Z","timestamp":744076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1993,7,31]]},"abstract":"<jats:p>OBJECTIVE--To compare the efficacy of two glibenclamide regimens in patients with non-insulin dependent diabetes who were fasting during Ramadan and regular glibenclamide treatment in the non-fasting group. DESIGN--Non-randomised control group of patients who did not fast during Ramadan and two groups of patients who fasted randomised equally to one of two regimens: to take their usual morning dose of glibenclamide in the evening and their usual evening dose before dawn; or to follow this pattern but to reduce the total dose by a quarter. SETTING--Two university hospitals, one private hospital, and two private clinics in Casablanca and Rabat, Morocco. SUBJECTS--591 diabetic patients (198 men, 391 women, two unspecified) with similar duration of diabetes and length and amount of glibenclamide treatment, of whom 542 completed the study. MAIN OUTCOME MEASURES--Serum fructosamine and total glycated haemoglobin concentrations and number of hypoglycaemic events. RESULTS--At the end of Ramadan there were no significant differences between the groups in fructosamine concentration (400 mumol\/l in controls and 381 mumol\/l and 376 mumol\/l in the fasting groups); percentage of glycated haemoglobin (14.7%, 14.0%, and 13.6%); or number of hypoglycaemic events during Ramadan (11, 14, and 10). CONCLUSION--Glibenclamide is effective and safe for patients with non-insulin dependent diabetes who fast during Ramadan. The easiest regimen is to take the normal morning dose (together with any midday dose) at sunset and any evening dose before dawn.<\/jats:p>","DOI":"10.1136\/bmj.307.6899.292","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"292-295","source":"Crossref","is-referenced-by-count":65,"title":["Muslims with non-insulin dependent diabetes fasting during Ramadan: treatment with glibenclamide."],"prefix":"10.1136","volume":"307","author":[{"given":"J","family":"Belkhadir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"el Ghomari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Kl\u00f6cker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mikou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nasciri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sabri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,7,31]]},"reference":[{"key":"ref_1","first-page":"521","article-title":"The fast of Ramadan. 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Effects of fasting during Ramadan on urinary excretion in Malaysian Muslims. Br J Nutr 1990;63: 329-37.","journal-title":"Br J Nutr"},{"key":"ref_10","first-page":"171","article-title":"Effect of Ramadan fasting on the values of haematological and biochemical parameters","volume":"8","author":"El-Hazmi, M.A.F.; Al-Faleh, F.Z.; Al-Mofleh, I.A.","year":"1987","unstructured":"El-Hazmi MAF, Al-Faleh FZ, Al-Mofleh IA. Effect of Ramadan fasting on the values of haematological and biochemical parameters. Saudi Medical Journal 1987;8: 171-6.","journal-title":"Saudi Medical Journal"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1515\/labm.1989.13.7-8.245","article-title":"A new colorimetric method for the determination of fructosamine","volume":"13","author":"Kruse-Jarres, J.D.; Jarausch, J.; Lehmann, P.; Vogt, B.W.; Rietz, P.","year":"1989","unstructured":"Kruse-Jarres JD, Jarausch J, Lehmann P, Vogt BW, Rietz P. 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Frankfurt: Hoechst AG, 1993."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.307.6899.292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.307.6899.292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:46:45Z","timestamp":1766429205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.307.6899.292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7,31]]},"references-count":17,"journal-issue":{"issue":"6899","published-online":{"date-parts":[[1993,7,31]]},"published-print":{"date-parts":[[1993,7,31]]}},"alternative-id":["10.1136\/bmj.307.6899.292"],"URL":"https:\/\/doi.org\/10.1136\/bmj.307.6899.292","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1993,7,31]]}}}