{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:30:51Z","timestamp":1770478251386,"version":"3.49.0"},"reference-count":11,"publisher":"BMJ","issue":"6905","license":[{"start":{"date-parts":[[1993,9,11]],"date-time":"1993-09-11T00:00:00Z","timestamp":747705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1993,9,11]]},"abstract":"<jats:p>OBJECTIVE--To compare the efficacy and safety of terbinafine 1% cream and clotrimazole 1% cream in the treatment of tinea pedis. DESIGN--Multicentre, double blind parallel group study. SETTING--32 general practices and one hospital. PATIENTS--256 patients with mycologically confirmed tinea pedis. Of the 211 patients evaluable, 107 were randomised to terbinafine (75 male, 32 female; mean (range) age 40 (12-81) years) and 104 to clotrimazole (79 male, 25 female; mean (range) age 36 (12-71) years). INTERVENTIONS--Terbinafine 1% cream applied twice daily for one week and inert cream applied twice daily for the next three weeks. Clotrimazole 1% cream applied twice daily for four weeks. MAIN OUTCOME MEASURES--Mycological cure (negative results on microscopy and culture) and effective treatment (mycological cure plus no or minimal signs and symptoms) measured at weeks 1, 2, 3, 4, and 6. RESULTS--At week four rates of mycological cure were 93.5% for terbinafine and 73.1% for clotrimazole (p = 0.0001); and at week six 97.2% for terbinafine and 83.7% for clotrimazole (p = 0.001). Rates of effective treatment at week 4 were 89.7% for terbinafine and 58.7% for clotrimazole (p = 0.0001); and 89.7% for terbinafine and 73.1% for clotrimazole (p = 0.002) at week 6. CONCLUSION--These results indicate that a one week course of terbinafine 1% cream is more effective in the treatment of tinea pedis than a four week course of clotrimazole 1% cream, both in terms of mycological cure and effective treatment.<\/jats:p>","DOI":"10.1136\/bmj.307.6905.645","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T08:16:37Z","timestamp":1238400997000},"page":"645-647","source":"Crossref","is-referenced-by-count":48,"title":["Comparison of terbinafine and clotrimazole in treating tinea pedis."],"prefix":"10.1136","volume":"307","author":[{"given":"E G","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Dodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G J","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/1523-1747.ep12521036","article-title":"Mechanisms of action of the antimycotic imidazoles","volume":"76","author":"Sud, I.J.; Fenigold, D.S.","year":"1981","unstructured":"Sud IJ, Fenigold DS. Mechanisms of action of the antimycotic imidazoles. J Invest Dermatol 1981;76:438-41.","journal-title":"J Invest Dermatol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1128\/AAC.31.9.1365","article-title":"Antifungal activity of the allylamine derivative terbinafine in vitro","volume":"31","author":"Petranyi, G.; Meingassner, J.G.; Meith, H.","year":"1987","unstructured":"Petranyi G, Meingassner JG, Meith H. Antifungal activity of the allylamine derivative terbinafine in vitro. AntimicrobAgents Chemother 1987;31:1365-8.","journal-title":"AntimicrobAgents Chemother"},{"key":"ref_3","first-page":"101","article-title":"In vitro activity of terbinafine. Clin Exp Dermatol","volume":"14","author":"Clayton, Y.M.","year":"1989","unstructured":"Clayton YM. In vitro activity of terbinafine. Clin Exp Dermatol 1989;14:101-4."},{"key":"ref_4","first-page":"124","article-title":"Clinical efficacy and tolerability of terbinafine (Lamisil)- a new topical and systemic fungicidal drug for treatmnent of dermatomycoses. Clin Exp Dermatol","volume":"14","author":"Villars, V.; Jones, T.C.","year":"1989","unstructured":"Villars V, Jones TC. Clinical efficacy and tolerability of terbinafine (Lamisil)- a new topical and systemic fungicidal drug for treatmnent of dermatomycoses. Clin Exp Dermatol 1989;14:124-7."},{"key":"ref_5","first-page":"795","article-title":"Efficacy and tolerability of topical terbinafine on the treatment of tinea cruris","volume":"23","author":"Millikan, L.E.","year":"1990","unstructured":"Millikan LE. Efficacy and tolerability of topical terbinafine on the treatment of tinea cruris. j7Am Acad Dermatol 1990;23:795-9."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0190-9622(90)70292-P","article-title":"Treatrnent of tinea cruris with topical terbinafine","volume":"23","author":"Greer, D.L.; HW, Jr, Jolly","year":"1990","unstructured":"Greer DL, Jolly HW Jr. Treatrnent of tinea cruris with topical terbinafine. JAm Acad Dermatol 1990;23:800-4.","journal-title":"JAm Acad Dermatol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/09546639209088719","article-title":"One week treatment of tinea corporis and tinea cruris with terbinafine (Lamisil) 1% cream: a placebo controlled study","volume":"3","author":"Evans, E.G.V.; James, I.G.V.; Joshipura, R.C.","year":"1992","unstructured":"Evans EGV, James IGV, Joshipura RC. One week treatment of tinea corporis and tinea cruris with terbinafine (Lamisil) 1% cream: a placebo controlled study. Journal ofDermatological Treatment 1992;3:181-4.","journal-title":"Journal ofDermatological Treatment"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/09546639109092729","article-title":"Two week treatment of tinea pedis with terbinafine (Lamisil) 1% cream: a placebo-controlled study","volume":"2","author":"Evans, E.G.V.; James, I.G.V.; Joshipura, R.C.","year":"1991","unstructured":"Evans EGV, James IGV, Joshipura RC. Two week treatment of tinea pedis with terbinafine (Lamisil) 1% cream: a placebo-controlled study. Journal of Dermatological Treatment 1991;2:95-7.","journal-title":"Journal of Dermatological Treatment"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/0190-9622(92)70141-2","article-title":"Efficacy of a 1 week, twice daily regimen of terbinafine 1% cream in the treatment of interdigital tinea pedis","volume":"26","author":"Berman, B.; Ellis, C.; Leydon, J.; Lowe, N.; Savin, R.; Shupack, J.","year":"1992","unstructured":"Berman B, Ellis C, Leydon J, Lowe N, Savin R, Shupack J, et al. Efficacy of a 1 week, twice daily regimen of terbinafine 1% cream in the treatment of interdigital tinea pedis. JAm Acad Dermatol 1992;26:956-60.","journal-title":"JAm Acad Dermatol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1365-2133.1992.tb00461.x","article-title":"An investigation of the pharmacokinetics of topical terbinafine (Lamisil) 1% cream","volume":"127","author":"Hill, S.; Thomas, R.; Smith, S.G.; Finlay, A.Y.","year":"1992","unstructured":"Hill S, Thomas R, Smith SG, Finlay AY. An investigation of the pharmacokinetics of topical terbinafine (Lamisil) 1% cream. Br J Dermatol 1992;127: 396-400.","journal-title":"Br J Dermatol"},{"key":"ref_11","first-page":"21","article-title":"A double-blind comparison of 1, 3, 5 and 7 day topical therapy with 1% terbinafine (Lamisil) cream in tinea pedis","volume":"127","author":"Evans, E.G.V.","year":"1992","unstructured":"Evans EGV. A double-blind comparison of 1, 3, 5 and 7 day topical therapy with 1% terbinafine (Lamisil) cream in tinea pedis. 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