{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:09:40Z","timestamp":1780387780449,"version":"3.54.1"},"reference-count":15,"publisher":"BMJ","issue":"6920","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[1993,10,15]]},"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    : To provide accurate estimates of the risk of lymphoma in patients with dermatitis herpetiformis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    : Comparison of observed and expected incidence of cancer in patients with dermatitis herpetiformis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects<\/jats:bold>\n                    : 976 patients aged 4 to 97 years with no clinical signs of coeliac disease who were admitted to hospital between 1963 and 1983.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting<\/jats:bold>\n                    : Data from Swedish Cancer Registry.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures<\/jats:bold>\n                    : Incidence and type of cancer.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : 106 cancers were diagnosed in 94 patients. The relative risk was 1.4 (95% confidence interval 1.1 to 1.7) in male patients and 1.2 (0.8 to 1.7) in female patients. When the individual cancer sites were analysed a significant risk was found only for malignant, non-Hodgkin's lymphoma in male patients, with a relative risk of 5.4 (2.2 to 11.1).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : The risk of lymphoma is greater in male patients with dermatitis herpetiformis, and this calls for increased surveillance in these patients.\n                  <\/jats:p>","DOI":"10.1136\/bmj.308.6920.13","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T19:17:43Z","timestamp":1319743063000},"page":"13","source":"Crossref","is-referenced-by-count":81,"title":["Risk of lymphoma in patients with dermatitis herpetiformis"],"prefix":"10.1136","volume":"308","author":[{"given":"B","family":"Sigurgeisson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Agnarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Lindelof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"2025122309021689000_308.6920.13.1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/bmj.286.6358.16","article-title":"Increased incidence of malignancy in dermatitis herpetiformis.","volume":"286","author":"Leonard","year":"1983","journal-title":"BMJ"},{"key":"2025122309021689000_308.6920.13.2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000249270","article-title":"Natural history of dermatitis herpetiformis in southern Sweden.","volume":"173","author":"Christensen","year":"1986","journal-title":"Dermatologica"},{"key":"2025122309021689000_308.6920.13.3","unstructured":"Swedish Cancer Registry .Cancer incidence in Sweden 1958\u20131987.Stockholm: National Board of Health and Welfare, 1960\u201391."},{"key":"2025122309021689000_308.6920.13.4","unstructured":"Mattsson B .Cancer registration in Sweden: studies on completeness and validity of incidence and mortality registers (thesis).Stockholm: Karolinska Institute, 1984."},{"key":"2025122309021689000_308.6920.13.5","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(91)90121-9"},{"key":"2025122309021689000_308.6920.13.6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/oxfordjournals.aje.a114001","article-title":"Use of Poisson regression models in estimating incidence rates and ratios.","volume":"121","author":"Frome","year":"1985","journal-title":"Am J Epidemiol"},{"key":"2025122309021689000_308.6920.13.7","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1136\/bmj.1.5696.610","article-title":"Dermatitis herpetiformis, steatorrhoea and malignancy.","volume":"i","author":"Gjone","year":"1970","journal-title":"BMJ"},{"key":"2025122309021689000_308.6920.13.8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0190-9622(83)70134-9","article-title":"Histiocytic lymphoma occurring in a patient with dermatitis herpetiformis.","volume":"9","author":"Jenkins","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"2025122309021689000_308.6920.13.9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2340\/0001555562343346","article-title":"Lymphoma in dermatitis herpetiformis: report on four cases.","volume":"62","author":"Reunala","year":"1982","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"2025122309021689000_308.6920.13.10","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/0016-5085(86)90275-1","article-title":"Small bowel malignant lymphoma complicting celiac sprue an the mesenteric lymph node cavitation syndrome.","volume":"90","author":"Freeman","year":"1986","journal-title":"Gastroenterology"},{"key":"2025122309021689000_308.6920.13.11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1136\/bmj.293.6552.908","article-title":"Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma.","volume":"292","author":"O'Farrelly","year":"1986","journal-title":"BMJ"},{"key":"2025122309021689000_308.6920.13.12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0738-081X(91)90028-J","article-title":"Malignant disease in dermatitis herpetiformis.","volume":"9","author":"Reunala","year":"1992","journal-title":"Clinics in Dermatology"},{"key":"2025122309021689000_308.6920.13.13","first-page":"221","article-title":"Dermatitis herpetiformis-a skin manifestation of a generalized disturbance in immunity.","volume":"186","author":"Davis","year":"1978","journal-title":"QJ 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