{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:06:51Z","timestamp":1791266811361,"version":"4.1.0"},"reference-count":35,"publisher":"BMJ","issue":"6955","license":[{"start":{"date-parts":[[1994,9,10]],"date-time":"1994-09-10T00:00:00Z","timestamp":779155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[1994,6,22]]},"published-print":{"date-parts":[[1994,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    : To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    : Cross sectional population based study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects<\/jats:bold>\n                    : 980 people aged 69 to 78 (349 men, 631 women).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting<\/jats:bold>\n                    : Population of Kuopio, eastern Finland.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures<\/jats:bold>\n                    : Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 in subjects without dementia (P&lt;0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.\n                  <\/jats:p>","DOI":"10.1136\/bmj.309.6955.636","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T19:30:18Z","timestamp":1319743818000},"page":"636-638","source":"Crossref","is-referenced-by-count":147,"title":["Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based 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