{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:51:22Z","timestamp":1789872682237,"version":"4.0.1"},"reference-count":24,"publisher":"BMJ","issue":"6968","license":[{"start":{"date-parts":[[1994,12,10]],"date-time":"1994-12-10T00:00:00Z","timestamp":787017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[1994,10,10]]},"published-print":{"date-parts":[[1994,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    : To investigate the prognostic significance of symptomatic primary HIV-1 infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    : Prospective study of homosexual men seroconverting to HIV in 1985 and 1986. Patients were followed up at least three times yearly with clinical examinations and T cell subset determinations for an average of 7.2 years.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting<\/jats:bold>\n                    : Research project centred on attenders for treatment and screening for HIV at the Karolinska Institute, Stockholm. Subjects\u201419 patients presenting with a glandularfever-like illness associated with seroconversion to HIV and 29 asymptomatic seroconverters.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures<\/jats:bold>\n                    : Progression to Centers for Disease Control and Prevention stage IV disease, CD4 cell count below 200 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    \/l, AIDS, and death from AIDS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Symptomatic seroconverters were significantly more likely to develop Centers for Disease Control and Prevention stage IV disease (95% (upsilon) 66%), CD4 cell counts below 200 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    \/l (84% (upsilon) 55%), and AIDS (58% (upsilon) 28%) and die of AIDS (53% (upsilon) 7%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : A glandular-fever-like illness associated with seroconversion to HIV-1 predicts accelerated progression to AIDS and other HIV related diseases.\n                  <\/jats:p>","DOI":"10.1136\/bmj.309.6968.1535","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T19:31:59Z","timestamp":1319743919000},"page":"1535-1537","source":"Crossref","is-referenced-by-count":56,"title":["Does symptomatic primary HIV-1 infection accelerate progression to CDC stage IV disease, CD4 count below 200 \u00d7 10\n                    <sup>6<\/sup>\n                    \/l, AIDS, and death from AIDS?: FIG"],"prefix":"10.1136","volume":"309","author":[{"given":"Stefan","family":"Lindback","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Brostrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Gaines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,12,10]]},"reference":[{"key":"2025122312362165000_309.6968.1535.1","first-page":"537","volume":"i","author":"Cooper","year":"1985","journal-title":"Acute AIDS retrovirus infection\u2013definition of a clinical illness associated with seroconversion, 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Clinical course of primary HIV infection: consequences for subsequent course of infection.","volume":"299","author":"Pedersen","year":"1989","journal-title":"BMJ"},{"key":"2025122312362165000_309.6968.1535.13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00002030-199301000-00008","article-title":"Predictors of rapid progression to AIDS in HIV-1 seroconverters.","volume":"7","author":"Keet","year":"1993","journal-title":"AIDS"},{"key":"2025122312362165000_309.6968.1535.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90006-X"},{"key":"2025122312362165000_309.6968.1535.15","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199010000-00008"},{"key":"2025122312362165000_309.6968.1535.16","first-page":"577","article-title":"Transmission of human immunodeficiency virus (HIV) in health-care settings worldwide.","volume":"67","author":"Marcus","year":"1989","journal-title":"Bull World Health Organ"},{"key":"2025122312362165000_309.6968.1535.17","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92029-2"},{"key":"2025122312362165000_309.6968.1535.18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00002030-199204000-00010","article-title":"Disease progression and early predictors of AIDS in HIV-seroconverted injecting drug users.","volume":"6","author":"Rezza","year":"1992","journal-title":"AIDS"},{"key":"2025122312362165000_309.6968.1535.19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/oxfordjournals.aje.a115445","article-title":"Prevalence, incidence, and progression of human immunodeficiency virus infection in homosexual and bisexual men in hepatitis B vaccine trials, 1978\u20131988.","volume":"130","author":"Hessol","year":"1989","journal-title":"Am J Epidemiol"},{"key":"2025122312362165000_309.6968.1535.20","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1136\/bmj.301.6762.1183","article-title":"Course of HIV infection in a cohort of homosexual and bisexual men: an 11 year follow up study.","volume":"301","author":"Rutherford","year":"1990","journal-title":"BMJ"},{"key":"2025122312362165000_309.6968.1535.21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420050075042"},{"key":"2025122312362165000_309.6968.1535.22","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/00002030-199011000-00002","article-title":"AIDS incubation in 1891 HIV seroconverters from different exposure groups.","volume":"4","author":"Biggar","year":"1990","journal-title":"AIDS"},{"key":"2025122312362165000_309.6968.1535.23","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93281-Q"},{"key":"2025122312362165000_309.6968.1535.24","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/aid.1993.9.913","article-title":"Summary of the National Institutes of Health workshop on primary human immunodeficiency virus type 1 infection.","volume":"9","author":"Niu","year":"1993","journal-title":"AIDS Res Hum Retroviruses"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.309.6968.1535","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.309.6968.1535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T20:36:31Z","timestamp":1766522191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.309.6968.1535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12,10]]},"references-count":24,"journal-issue":{"issue":"6968","published-online":{"date-parts":[[1994,12,10]]},"published-print":{"date-parts":[[1994,12,10]]}},"alternative-id":["10.1136\/bmj.309.6968.1535"],"URL":"https:\/\/doi.org\/10.1136\/bmj.309.6968.1535","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12,10]]}}}