{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T17:31:26Z","timestamp":1766683886161,"version":"3.48.0"},"reference-count":18,"publisher":"BMJ","issue":"6980","license":[{"start":{"date-parts":[[1995,3,11]],"date-time":"1995-03-11T00:00:00Z","timestamp":794880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[1994,12,30]]},"published-print":{"date-parts":[[1995,3,11]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:bold>\n : To determine the diagnostic accuracy of examining bronchial secretions in pulmonary cytopathology and whether cytology and histopathology can complement each other in routine practice among lung specialists.\n <\/jats:p>\n \n Design<\/jats:bold>\n : A prospective study comparing 1225 cytological and biopsy results, conducted during 1987-93. Tumours were confirmed by histopathology, imaging techniques, or clinical outcome and imaging techniques combined.\n <\/jats:p>\n \n Setting<\/jats:bold>\n : 11 lung or internal medicine units, France.\n <\/jats:p>\n \n Subjects<\/jats:bold>\n : 1128 patients (874 men; 254 women) aged 65.3 (SD 13.7) years who underwent fibreoptic bronchoscopy for various pulmonary symptoms.\n <\/jats:p>\n \n Results<\/jats:bold>\n : Exact concordance between cytological and biopsy results was obtained in 1036\/1187 (87.3%) satisfactory specimens. In all 574 lung tumours were diagnosed. One case (0.08%) was a false positive cytological diagnosis in a patient with tuberculosis. Patients with lung cancer were more likely to have positive cytological results than positive biopsy results (P<0.001). Agreement in tumour typing was observed in 375\/424 (88.4%) cases, when non-small cell carcinomas, small cell carcinomas and undifferentiated carcinomas were separated. In the 11 patients with squamous cell carcinomas in situ, eight (72.7%) of the carcinomas were diagnosed cytologically as squamous cell. Unsatisfactory material was obtained in only 20 (1.6%) and 19 (1.6%) cases by cytology and biopsy respectively. Examinations had to be repeated in 86 (7.6%) patients.\n <\/jats:p>\n \n Conclusions<\/jats:bold>\n : Examination of bronchial secretions complements histopathology in both diagnosing and typing lung tumours and could be performed more systematically in patients undergoing fibreoptic bronchoscopy.\n <\/jats:p>\n \n \n \n Key messages<\/jats:title>\n \n \n Key messages<\/jats:p>\n <\/jats:list-item>\n \n In this study an accuracy of 88.4% was achieved in typing lung tumours by examining bronchial secretions<\/jats:p>\n <\/jats:list-item>\n \n Repeated examinations for confirmation or to resolve apparent discrepancies led to confirmation of previous findings in two thirds of cases and to the recognition of malignancy in a third of cases<\/jats:p>\n <\/jats:list-item>\n \n Simple aspiration of bronchial secretions is of value in diagnosing and typing lung tumours<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>\n <\/jats:boxed-text>\n <\/jats:p>","DOI":"10.1136\/bmj.310.6980.624","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T19:33:32Z","timestamp":1319744012000},"page":"624-627","source":"Crossref","is-referenced-by-count":13,"title":["Prospective study of combined use of bronchial aspirates and biopsy specimens in diagnosis and typing of centrally located lung tumours"],"prefix":"10.1136","volume":"310","author":[{"given":"Eric","family":"Piaton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Helene","family":"Grillet-Ravigneaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Saugier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Pellet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,3,11]]},"reference":[{"key":"2025122509283054000_310.6980.624.1","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/jnci\/83.16.1142","article-title":"Smoking-attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States?","volume":"83","author":"Shopland","year":"1991","journal-title":"J Natl Cancer Inst"},{"key":"2025122509283054000_310.6980.624.2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/1097-0142(19920801)70:3<599::AID-CNCR2820700310>3.0.CO;2-9","article-title":"Detection of large cell component in small cell lung carcinoma by combined cytologic and histologic examination and its clinical implication.","volume":"70","author":"Fushimi","year":"1992","journal-title":"Cancer"},{"key":"2025122509283054000_310.6980.624.3","unstructured":"Johnston WW Elson CE .Respiratory tract. In: Bibbo M ed.Comprehensive cytopathology. Philadelphia: W B Saunders,1991: 320\u201398."},{"key":"2025122509283054000_310.6980.624.4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.7.589"},{"key":"2025122509283054000_310.6980.624.5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/dc.2840070104","article-title":"Cytological typing of primary lung cancer: study of 100 cases with autopsy confirmation.","volume":"7","author":"DiBonito","year":"1991","journal-title":"Diagn Cytopathol"},{"key":"2025122509283054000_310.6980.624.6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/10520298109067314","article-title":"Differential nucleolar staining affinity with a modified Papanicolaou staining procedure.","volume":"56","author":"Mouriquand","year":"1981","journal-title":"Stain Technology"},{"key":"2025122509283054000_310.6980.624.7","unstructured":"Kreyberg L .Histological typing of lung tumours. International histological classification of tumours.2nd ed. Geneva: WHO,1981."},{"key":"2025122509283054000_310.6980.624.8","first-page":"104","article-title":"Pulmonary cytology: a brief survey of diagnostic results from July 1, 1952, until December 31, 1960.","volume":"8","author":"Koss","year":"1964","journal-title":"Acta Cytol"},{"key":"2025122509283054000_310.6980.624.9","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1055\/s-0028-1106369","article-title":"Ergebnisse zytologischer Untersuchungen des Bronchialsekrets bei Lungentumoren im Verhaltnis zum Tumorstadium (TNM system).","volume":"100","author":"Atay","year":"1975","journal-title":"Dtsch Med Wochenschr"},{"key":"2025122509283054000_310.6980.624.10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/thx.34.3.294","article-title":"Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma.","volume":"34","author":"Payne","year":"1979","journal-title":"Thorax"},{"key":"2025122509283054000_310.6980.624.11","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91839-M"},{"key":"2025122509283054000_310.6980.624.12","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199312000-00004"},{"key":"2025122509283054000_310.6980.624.13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/ajcp\/73.1.36","article-title":"A study of variability in cytologic diagnoses based on pulmonary aspiration specimens.","volume":"73","author":"Taft","year":"1980","journal-title":"Am J Clin Pathol"},{"key":"2025122509283054000_310.6980.624.14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1136\/jcp.47.5.477","article-title":"Diagnostic value of examining bronchial secretions in pulmonary cytopathology.","volume":"47","author":"Piaton","year":"1994","journal-title":"J Clin Pathol"},{"key":"2025122509283054000_310.6980.624.15","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.12.997"},{"key":"2025122509283054000_310.6980.624.16","first-page":"963","article-title":"The identification of types of pulmonary cancer in cytological smears.","volume":"28","author":"Foot","year":"1952","journal-title":"Am J Pathol"},{"key":"2025122509283054000_310.6980.624.17","first-page":"327","article-title":"Cytologic typing of lung cancer.","volume":"16","author":"Lange","year":"1972","journal-title":"Acta Cytol"},{"key":"2025122509283054000_310.6980.624.18","first-page":"379","article-title":"Diagnosis and typing of lung carcinomas by cytopathologic methods. A review of 108 cases.","volume":"29","author":"Truong","year":"1985","journal-title":"Acta Cytol"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.310.6980.624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.310.6980.624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T17:28:37Z","timestamp":1766683717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.310.6980.624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,11]]},"references-count":18,"journal-issue":{"issue":"6980","published-online":{"date-parts":[[1995,3,11]]},"published-print":{"date-parts":[[1995,3,11]]}},"alternative-id":["10.1136\/bmj.310.6980.624"],"URL":"https:\/\/doi.org\/10.1136\/bmj.310.6980.624","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1995,3,11]]}}}