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For treating trigeminal neuralgia, carbamazepine had a combined number needed to treat of 2.6 for effectiveness, 3.4 for adverse effects, and 24 for severe effects (withdrawal from study). For treating diabetic neuropathy, anticonvulsants had a combined number needed to treat of 2.5 for effectiveness, 3.1 for adverse effects, and 20 for severe effects. For migraine prophylaxis, anticonvulsants had a combined number needed to treat of 1.6 for effectiveness, 2.4 for adverse effects, and 39 for severe effects. Phenytoin had no effect on the irritable bowel syndrome, and carbamazepine had little effect on pain after stroke. Clonazepam was effective in one study for temporomandibular joint dysfunction. No study compared one anticonvulsant with another.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Anticonvulsants were effective for trigeminal neuralgia and diabetic neuropathy and for migraine prophylaxis. Minor adverse effects occurred as often as benefit.\n                  <\/jats:p>","DOI":"10.1136\/bmj.311.7012.1047","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T19:37:39Z","timestamp":1319744259000},"page":"1047-1052","source":"Crossref","is-referenced-by-count":530,"title":["Anticonvulsant drugs for management of pain: a systematic review"],"prefix":"10.1136","volume":"311","author":[{"given":"Henry","family":"McQuay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro R","family":"Jadad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wiffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1995,10,21]]},"reference":[{"key":"2025122208085674000_311.7012.1047.1","unstructured":"Jacox A Carr DB Payne R .Management of cancer pain. Clinical practice guideline No 9. Agency for Health Care Policy and Research, US Department of Health and Human Services. Rockville, MD: Public Health Service,1994: 41\u201374. (AHCPR Publication No 94\u20130592.)"},{"key":"2025122208085674000_311.7012.1047.2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90086-8"},{"key":"2025122208085674000_311.7012.1047.3","unstructured":"Loeser JD .Tic douloureux and atypical facial pain. In: Wall PD Melzack R eds.Textbook of pain.3rd ed. London: Churchill Livingstone,1994: 699\u2013710."},{"key":"2025122208085674000_311.7012.1047.4","unstructured":"Twycross R .The management of pain in cancer. In: Nimmo WS Rowbotham DJ Smith G eds.Anaesthesia.2nd ed. Oxford: Blackwell Science,1994: 1635\u201351."},{"key":"2025122208085674000_311.7012.1047.5","unstructured":"Monks R .Psychotropic drugs. In: Wall PD Melzack R eds.Textbook of pain.3rd ed. 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