{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T19:24:51Z","timestamp":1766690691108,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"7055","license":[{"start":{"date-parts":[[1996,8,24]],"date-time":"1996-08-24T00:00:00Z","timestamp":840844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[1996,6,17]]},"published-print":{"date-parts":[[1996,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    : To analyse the association between use of antihypertensive treatment, diastolic blood pressure, and long term incidence of ischaemic cardiac events in elderly men.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    : Population based cohort study. Baseline examination in 1982-3 and follow up for up to 10 years.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting<\/jats:bold>\n                    : Malmo, Sweden.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects<\/jats:bold>\n                    : 484 randomly selected men born in 1914 and living in Malmo during 1982.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures<\/jats:bold>\n                    : Observational comparisons of incidence rates and rate and hazard ratios of ischaemic cardiac events (myocardial infarction or death due to chronic ischaemic cardiac disease).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : The crude incidence rate of ischaemic cardiac events was higher in those subjects who were taking antihypertensive drugs than in those who were not (rate ratio 2.6 (95% confidence interval 1.7 to 3.9)). After adjustment for potential confounders (differences in baseline smoking habits, blood pressure, time since diagnosis of hypertension, ischaemic or other cardiovascular disease, hypercholesterolaemia, hypertriglyceridaemia, diabetes mellitus, obesity, and raised serum creatinine concentration) this rate was reduced but still raised (hazard ratio 1.9 (1.0 to 3.7)). In men with diastolic blood pressure &gt;90 mm Hg, antihypertensive treatment was associated with a twofold increase in the incidence of ischaemic cardiac events (rate ratio 2.0 (1.1 to 3.6)), which vanished after adjustment for potential confounders (hazard ratio 1.1 (0.5 to 2.6)). In those subjects with diastolic blood pressure &lt;\/=90 mm Hg, antihypertensive treatment was associated with fourfold increase in incidence (rate ratio 3.9 (2.1 to 7.1)), which remained after adjustment for potential confounders (hazard ratio 3.8 (1.3 to 11.0)).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : Antihypertensive treatment may increase the risk of myocardial infarction in elderly men with treated diastolic blood pressures &lt;\/=90 mm Hg.\n                  <\/jats:p>","DOI":"10.1136\/bmj.313.7055.457","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T16:59:49Z","timestamp":1320080389000},"page":"457-461","source":"Crossref","is-referenced-by-count":33,"title":["Incidence of myocardial infarction in elderly men being treated with antihypertensive drugs: population based cohort study"],"prefix":"10.1136","volume":"313","author":[{"given":"Juan","family":"Merlo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Ranstam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Liedholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Hedblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Lindblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven-Olof","family":"Isacsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Melander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Rastam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,8,24]]},"reference":[{"issue":"(suppl 5)","key":"2025122310541967000_313.7055.457.1","first-page":"136","article-title":"Controlled clinical trials of drug treatment for hypertension","volume":"13","author":"Cutler","year":"1989","journal-title":"Hypertension"},{"key":"2025122310541967000_313.7055.457.2","unstructured":"Collins R Peto R . Antihypertensive drug therapy: effects on stroke and coronary heart disease. In: Swales JD, ed. Textbook of hypertension. Oxford: Blackwell, 1994:1156-64."},{"key":"2025122310541967000_313.7055.457.3","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92570-8"},{"key":"2025122310541967000_313.7055.457.4","first-page":"481","article-title":"Is blood pressure treatment as effective in a population setting as in controlled trials? Results from a prospective study.","volume":"12","author":"Thurmer","year":"1994","journal-title":"J Hypertens"},{"key":"2025122310541967000_313.7055.457.5","first-page":"53","article-title":"Blood pressure and mortality: an epidemiological survey with 10 years follow-up.","volume":"6","author":"Clausen","year":"1992","journal-title":"J Hum Hypertens"},{"key":"2025122310541967000_313.7055.457.6","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(83)90145-5"},{"key":"2025122310541967000_313.7055.457.7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(87)90231-5","article-title":"Benefits and potential harm of lowering high blood pressure","volume":"i","author":"Cruickshank","year":"1987","journal-title":"Lancet"},{"key":"2025122310541967000_313.7055.457.8","first-page":"489","article-title":"The J-curve phenomenon and the treatment of hypertension.","volume":"265","author":"Farnett","year":"1991","journal-title":"Is there a point beyond which pressure reduction is dangerous? JAMA"},{"key":"2025122310541967000_313.7055.457.9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/bmj.308.6930.681","article-title":"Control of blood pressure and risk of first acute myocardial infarction: Skaraborg hypertension project.","volume":"308","author":"Lindblad","year":"1994","journal-title":"BMJ"},{"key":"2025122310541967000_313.7055.457.10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.HYP.22.4.551","article-title":"Blood pressure change and survival after age 74.","volume":"22","author":"Langer","year":"1993","journal-title":"Hypertension"},{"key":"2025122310541967000_313.7055.457.11","unstructured":"Isacsson S-O . Venous occlusion plethysmography in 55-year-old men. A population study in Malmo, Sweden [dissertation]. Acta Med Scand 1972;537 (suppl)."},{"key":"2025122310541967000_313.7055.457.12","doi-asserted-by":"publisher","DOI":"10.1136\/jech.40.2.174"},{"key":"2025122310541967000_313.7055.457.13","unstructured":"Rose GA Blackburn H . Cardiovascular survey methods. Geneva: WHO, 1968."},{"key":"2025122310541967000_313.7055.457.14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.HYP.20.1.32","article-title":"Hypertension and ST segment depression during ambulatory electrocardiograph recording. Results from the prospective study \u00e2\u0080\u009cMen born in 1914\u00e2\u0080\u009d from Malmo, Sweden.","volume":"20","author":"Hedblad","year":"1992","journal-title":"Hypertension"},{"key":"2025122310541967000_313.7055.457.15","first-page":"178","volume":"3","year":"1995","journal-title":"Information from the Medical Products Agency, Sweden"},{"key":"2025122310541967000_313.7055.457.16","first-page":"17","article-title":"Hazard of obesity\u00e2\u0080\u0094the Norwegian experience.","volume":"723","author":"Waaler","year":"1988","journal-title":"Acta Med Scand"},{"key":"2025122310541967000_313.7055.457.17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0277-9536(87)90043-8","article-title":"Different social network and social support characteristics, nervous problems and insomnia: theoretical and methodological aspects on some results from the population study \u00e2\u0080\u009cMen born in 1914, Malmo, Sweden.\u00e2\u0080\u009d","volume":"25","author":"Hanson","year":"1987","journal-title":"Soc Sci Med"},{"key":"2025122310541967000_313.7055.457.18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/08037059309077535","article-title":"The 1993 guidelines for the management of mild hypertension: memorandum from a WHO\/ISH meeting.","volume":"2","author":"Zanchetti","year":"1993","journal-title":"Blood Pressure"},{"key":"2025122310541967000_313.7055.457.19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2165\/00002512-199507020-00003","article-title":"Optimising diuretic therapy in elderly patients with hypertension.","volume":"7","author":"Cushman","year":"1995","journal-title":"Drugs Aging"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.313.7055.457","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.313.7055.457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:54:34Z","timestamp":1766516074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.313.7055.457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8,24]]},"references-count":19,"journal-issue":{"issue":"7055","published-online":{"date-parts":[[1996,8,24]]},"published-print":{"date-parts":[[1996,8,24]]}},"alternative-id":["10.1136\/bmj.313.7055.457"],"URL":"https:\/\/doi.org\/10.1136\/bmj.313.7055.457","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"type":"print","value":"0959-8138"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1996,8,24]]}}}