{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:08:36Z","timestamp":1793196516376,"version":"4.5.0"},"reference-count":5,"publisher":"BMJ","issue":"7080","license":[{"start":{"date-parts":[[1997,2,22]],"date-time":"1997-02-22T00:00:00Z","timestamp":856569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[1996,12,6]]},"published-print":{"date-parts":[[1997,2,22]]},"abstract":"Abstract<\/jats:title>\n \n Objective:<\/jats:bold>\n To determine whether eradication of\n Helicobacter pylori<\/jats:italic>\n infection reduces recurrence of benign gastric ulceration.\n <\/jats:p>\n \n Design:<\/jats:bold>\n Randomised, double blind, controlled study. Patients were randomised in a 1:2 ratio to either omeprazole 40 mg once daily for eight weeks or the same treatment plus amoxycillin 750 mg twice daily for weeks 7 and 8. A 12 month untreated follow up ensued.\n <\/jats:p>\n \n Setting:<\/jats:bold>\n Teaching and district general hospitals between 1991 and 1994.\n <\/jats:p>\n \n Subjects:<\/jats:bold>\n 107 patients with benign gastric ulcer associated with\n H pylori<\/jats:italic>\n .\n <\/jats:p>\n \n Main outcome measures:<\/jats:bold>\n Endoscopically confirmed relapse with gastric ulcer (analysed with life table methods),\n H pylori<\/jats:italic>\n eradication, and healing of gastric ulcers (Mantel-Haenszel test).\n <\/jats:p>\n \n Results:<\/jats:bold>\n 172 patients were enrolled. Malignancy was diagnosed in 19; 24 were not infected with\n H pylori<\/jats:italic>\n ; four withdrew because of adverse events; and 18 failed to attend for start of treatment, leaving 107 patients eligible for analysis (35 omeprazole alone; 72 omeprazole plus amoxycillin). In the omeprazole\/amoxycillin group 93% (67\/72; 95% confidence interval 84% to 98%) of gastric ulcers healed and 83% (29\/35; 66% to 94%) in the omeprazole group (P=0.103). Eradication of\n H pylori<\/jats:italic>\n was 58% (42\/72; 46% to 70%) and 6% (2\/35; 1% to 19%) (P<0.001) and relapse after treatment was 22% (16\/72) and 49% (17\/35) (life table analysis, P<0.001), in the two groups, respectively. The recurrence rates were 7% (3\/44) after successful\n H pylori<\/jats:italic>\n eradication and 48% (30\/63) in those who continued to be infected (P<0.001).\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n Eradication of\n H pylori<\/jats:italic>\n reduces relapse with gastric ulcer over one year. Eradication rates achieved with this regimen, however, are too low for it to be recommended for routine use.\n <\/jats:p>\n \n \n \n Key messages<\/jats:title>\n \n \n \n The occurrence of gastric ulcer is positively associated with\n H pylori<\/jats:italic>\n infection\n <\/jats:p>\n <\/jats:list-item>\n \n \n Treatment to eradicate\n H pylori<\/jats:italic>\n (omeprazole 40 mg once daily and amoxycillin 750 mg twice daily) reduces recurrence of gastric ulcers compared with omeprazole treatment alone\n <\/jats:p>\n <\/jats:list-item>\n \n \n Regardless of the treatment given, rates of recurrence of gastric ulcers were lower in patients with successful\n H pylori<\/jats:italic>\n eradication compared with those who continued to be infected\n <\/jats:p>\n <\/jats:list-item>\n \n \n The rate of eradication of\n H pylori<\/jats:italic>\n was 58% in the omeprazole\/amoxycillin treatment group\n <\/jats:p>\n <\/jats:list-item>\n \n Rates of healing of gastric ulcers were not significantly higher in those patients who received eradication treatment<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>\n <\/jats:boxed-text>\n <\/jats:p>","DOI":"10.1136\/bmj.314.7080.565","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T19:45:20Z","timestamp":1319744720000},"page":"565","source":"Crossref","is-referenced-by-count":42,"title":["Randomised double blind controlled study of recurrence of gastric ulcer after treatment for eradication of\n Helicobacter pylori<\/i>\n infection"],"prefix":"10.1136","volume":"314","author":[{"given":"A T R","family":"Axon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"\u00d3'Mor\u00e1in","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K D","family":"Bardhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P H","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P M","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F D","family":"Hollanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A F","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Tompkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Birrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K R W","family":"Gillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,2,22]]},"reference":[{"key":"2025122313120113000_314.7080.565.1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.7326\/0003-4819-120-12-199406150-00001","article-title":"Helicobacter pylori infection and the risk for duodenal and gastric ulceration.","volume":"120","author":"Nomura","year":"1994","journal-title":"Ann Intern Med"},{"key":"2025122313120113000_314.7080.565.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520010077036"},{"key":"2025122313120113000_314.7080.565.3","first-page":"5116","article-title":"Helicobacter pylori.","volume":"89","author":"Marshall","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025122313120113000_314.7080.565.4","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/gut.36.6.834","article-title":"Cure of peptic gastric ulcer associated with eradication of Helicobacter pylori.","volume":"36","year":"1995","journal-title":"Gut"},{"key":"2025122313120113000_314.7080.565.5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJM199501193320302","article-title":"Antibacterial treatment of gastric ulcers associated with Helicobacter pylori.","volume":"332","author":"Sung","year":"1995","journal-title":"N Engl J Med"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.314.7080.565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.314.7080.565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T21:12:08Z","timestamp":1766524328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.314.7080.565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,22]]},"references-count":5,"journal-issue":{"issue":"7080","published-online":{"date-parts":[[1997,2,22]]},"published-print":{"date-parts":[[1997,2,22]]}},"alternative-id":["10.1136\/bmj.314.7080.565"],"URL":"https:\/\/doi.org\/10.1136\/bmj.314.7080.565","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2,22]]}}}