{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:52:30Z","timestamp":1791093150877,"version":"4.1.0"},"reference-count":13,"publisher":"BMJ","issue":"7427","license":[{"start":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T00:00:00Z","timestamp":1070496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[2003,10,21]]},"published-print":{"date-parts":[[2003,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    To assess the effectiveness of penicillin for three days and treatment for seven days compared with placebo in resolving symptoms in children with sore throat.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    Randomised, double blind, placebo controlled trial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting<\/jats:bold>\n                    43 family practices in the Netherlands\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Participants<\/jats:bold>\n                    156 children aged 4-15 who had a sore throat for less than seven days and at least two of the four Centor criteria (history of fever, absence of cough, swollen tender anterior cervical lymph nodes, and tonsillar exudate).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Interventions<\/jats:bold>\n                    Patients were randomly assigned to penicillin for seven days, penicillin for three days followed by placebo for four days, or placebo for seven days.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures<\/jats:bold>\n                    Duration of symptoms, mean consumption of analgesics, number of days of absence from school, occurrence of streptococcal sequelae, eradication of the initial pathogen, and recurrences of sore throat after six months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    Penicillin treatment was not more beneficial than placebo in resolving symptoms of sore throat, neither in the total group nor in the 96 children with group A streptococci. In the groups randomised to seven days of penicillin, three days of penicillin, or placebo, one, two, and eight children, respectively, experienced a streptococcal sequela\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    Penicillin treatment had no beneficial effect in children with sore throat on the average duration of symptoms. Penicillin may, however, reduce streptococcal sequelae.\n                  <\/jats:p>","DOI":"10.1136\/bmj.327.7427.1324","type":"journal-article","created":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T18:33:09Z","timestamp":1070562789000},"page":"1324","source":"Crossref","is-referenced-by-count":75,"title":["Penicillin for acute sore throat in children: randomised, double blind trial"],"prefix":"10.1136","volume":"327","author":[{"given":"Sjoerd","family":"Zwart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroeska M","family":"Rovers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruut A","family":"de Melker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno W","family":"Hoes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,12,4]]},"reference":[{"key":"2025122510135933000_327.7427.1324.1","doi-asserted-by":"publisher","DOI":"10.1086\/340949"},{"key":"2025122510135933000_327.7427.1324.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7228.150"},{"key":"2025122510135933000_327.7427.1324.3","doi-asserted-by":"crossref","unstructured":"Del Mar CB Glasziou PP Spinks AB . Antibiotics for sore throat. Cochrane Database Syst Rev 2000;(4): CD000023","DOI":"10.1002\/14651858.CD000023"},{"key":"2025122510135933000_327.7427.1324.4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/0272989X8100100304","article-title":"The diagnosis of strep throat in adults in the emergency room.","volume":"1","author":"Centor","year":"1981","journal-title":"Med Decis Making"},{"key":"2025122510135933000_327.7427.1324.5","unstructured":"Dagnelie CF Zwart S Balder FA Romeijnders ACM Geijer RMM . NHG Standard \u201cAcute sore throat.\u201d Utrecht: Dutch College of General Practitioners, 2002. http:\/\/nhg.artsennet.nl\/guidelines2\/E11.htm (accessed 21 Nov 2003)."},{"key":"2025122510135933000_327.7427.1324.6","unstructured":"Scottish Intercollegiate Guidelines Network . Guideline 34: management of sore throat and indications for tonsillectomy. Edinburgh: Royal College of Physicians, 2001. http:\/\/www.sign.ac.uk\/guidelines\/fulltext\/34\/summary.html (accessed 17 Nov 2003)."},{"key":"2025122510135933000_327.7427.1324.7","doi-asserted-by":"publisher","DOI":"10.1080\/003655400750044944"},{"key":"2025122510135933000_327.7427.1324.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00157398"},{"key":"2025122510135933000_327.7427.1324.9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/02813439709018506","article-title":"The prevalence of beta-hemolytic streptococci in throat specimens from healthy children and adults. Implications for the clinical value of throat cultures.","volume":"15","author":"Gunnarsson","year":"1997","journal-title":"Scand J Prim Health Care"},{"key":"2025122510135933000_327.7427.1324.10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.5.689"},{"key":"2025122510135933000_327.7427.1324.11","unstructured":"Ruoff KL Whiley RA Beighton D . Streptococcus. Murray PR Baron EJ Pfaller MA Tenover FC Yolken RH eds. Manual of clinical microbiology. 7th ed. Washington: ASM Press, 1999: 283\u201396."},{"key":"2025122510135933000_327.7427.1324.12","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1542\/peds.64.6.904","article-title":"Significance of quantitative salivary cultures for group A and non-group A beta-hemolytic streptococci in patients with pharyngitis and in their family contacts.","volume":"64","author":"Kaplan","year":"1979","journal-title":"Pediatrics"},{"key":"2025122510135933000_327.7427.1324.13","doi-asserted-by":"publisher","DOI":"10.1086\/375589"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.327.7427.1324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.327.7427.1324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T18:14:11Z","timestamp":1766686451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.327.7427.1324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,4]]},"references-count":13,"journal-issue":{"issue":"7427","published-online":{"date-parts":[[2003,12,4]]},"published-print":{"date-parts":[[2003,12,6]]}},"alternative-id":["10.1136\/bmj.327.7427.1324"],"URL":"https:\/\/doi.org\/10.1136\/bmj.327.7427.1324","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,4]]}}}