{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:15:05Z","timestamp":1792088105990,"version":"4.4.0"},"reference-count":38,"publisher":"BMJ","issue":"7437","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"accepted":{"date-parts":[[2003,11,14]]},"published-print":{"date-parts":[[2004,2,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    To reassess the prevalence of aspirin induced asthma and other issues related to the syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Data sources<\/jats:bold>\n                    Biosis, SciSearch (1990 to March 2002), Embase (1974 to March 2002), Medline (1966 to March 2002), Toxline, Derwent Drug File (1964 to March 2002), Conference Papers Index and Inside Conferences, Int'l Pharmaceutical Abstracts, Pharma-Online (1978 to March 2002).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Selection criteria<\/jats:bold>\n                    Study type, patient population, and outcome measures. Review was restricted to respiratory responses to analgesics available without prescription.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    The prevalence of aspirin induced asthma was highest when determined by oral provocation testing (adults 21%, 95% confidence interval 14% to 29%; children 5%, 0% to 14%) than by verbal history (adults 3%, 2% to 4%; children 2%, 1% to 3%). Cross sensitivity to doses of over the counter non-steroidal anti-inflammatory drugs was present in most patients with aspirin induced asthma: ibuprofen, 98%; naproxen, 100%; and diclofenac, 93%. The incidence of cross sensitivity to paracetamol among such patients was only 7%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    Aspirin induced asthma in adults is more prevalent than previously suggested. When there is a clinical necessity to use aspirin or a non-steroidal anti-inflammatory drug and there is uncertainty about safety, oral provocation testing should be performed.\n                  <\/jats:p>","DOI":"10.1136\/bmj.328.7437.434","type":"journal-article","created":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T18:27:58Z","timestamp":1077215278000},"page":"434","source":"Crossref","is-referenced-by-count":346,"title":["Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice"],"prefix":"10.1136","volume":"328","author":[{"given":"Christine","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"2025122511135784000_328.7437.434.1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90106-3"},{"key":"2025122511135784000_328.7437.434.2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90115-5"},{"key":"2025122511135784000_328.7437.434.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162468699"},{"key":"2025122511135784000_328.7437.434.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12841-3"},{"key":"2025122511135784000_328.7437.434.5","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116290"},{"key":"2025122511135784000_328.7437.434.6","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/clpt.1986.214","article-title":"Rates of sensitivity reactions to aspirin: problems in interpreting the data.","volume":"40","author":"Kwoh","year":"1986","journal-title":"Clin Pharmacol Ther"},{"key":"2025122511135784000_328.7437.434.7","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200124110-00004"},{"key":"2025122511135784000_328.7437.434.8","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.569"},{"key":"2025122511135784000_328.7437.434.9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15e09.x"},{"key":"2025122511135784000_328.7437.434.10","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(72)90014-0"},{"key":"2025122511135784000_328.7437.434.11","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1975.00330060021002"},{"key":"2025122511135784000_328.7437.434.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1976.tb01896.x"},{"key":"2025122511135784000_328.7437.434.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1976.tb01889.x"},{"key":"2025122511135784000_328.7437.434.14","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90059-9"},{"key":"2025122511135784000_328.7437.434.15","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90080-0"},{"key":"2025122511135784000_328.7437.434.16","first-page":"226","article-title":"Aspirin intolerance: relationship with severity of clinical characteristics of asthma (abstract).","volume":"63","author":"Picado","year":"1982","journal-title":"Eur J Respir Dis"},{"key":"2025122511135784000_328.7437.434.17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/02770908309078051","article-title":"Acetaminophen and aspirin challenges in subgroups of asthmatics.","volume":"20","author":"Falliers","year":"1983","journal-title":"J Asthma"},{"key":"2025122511135784000_328.7437.434.18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000194922","article-title":"Prevalence of aspirin intolerance in asthmatics treated in a hospital.","volume":"50","author":"Castillo","year":"1986","journal-title":"Respiration"},{"key":"2025122511135784000_328.7437.434.19","first-page":"205","article-title":"Intoleranz und allergie gegen analgetika.","volume":"13","author":"Milosevic","year":"1990","journal-title":"Allergologie Jahrgang"},{"key":"2025122511135784000_328.7437.434.20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1164\/ajrccm\/146.1.76","article-title":"Long-term prognosis of near-fatal asthma: a 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma.","volume":"146","author":"Marquette","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2025122511135784000_328.7437.434.21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.56.3.443","article-title":"Aspirin intolerance in chronic childhood asthma: detected by oral challenge.","volume":"56","author":"Rachelefsky","year":"1975","journal-title":"Pediatrics"},{"key":"2025122511135784000_328.7437.434.22","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90077-X"},{"key":"2025122511135784000_328.7437.434.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1979.tb01526.x"},{"key":"2025122511135784000_328.7437.434.24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1542\/peds.71.3.313","article-title":"Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma.","volume":"71","author":"Fischer","year":"1983","journal-title":"Pediatrics"},{"key":"2025122511135784000_328.7437.434.25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1542\/peds.73.5.631","article-title":"Role of acetyl salicylic acid and sodium metabisulfite in chronic childhood asthma.","volume":"73","author":"Towns","year":"1984","journal-title":"Pediatrics"},{"key":"2025122511135784000_328.7437.434.26","first-page":"1016","article-title":"Aspirin allergy.","volume":"76","author":"Walton","year":"1957","journal-title":"Can Med Assoc J"},{"key":"2025122511135784000_328.7437.434.27","unstructured":"Pearson RSB . Hypersensitivity to aspirin. In: Dixon A Martin KB eds. Salicylates: an international symposium. London: Churchill, 1963: 170\u20133."},{"key":"2025122511135784000_328.7437.434.28","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(74)90080-3"},{"key":"2025122511135784000_328.7437.434.29","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(73)90030-4"},{"key":"2025122511135784000_328.7437.434.30","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(76)90102-0"},{"key":"2025122511135784000_328.7437.434.31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/bmj.2.6081.231","article-title":"Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen.","volume":"2","author":"Szczeklik","year":"1977","journal-title":"BMJ"},{"key":"2025122511135784000_328.7437.434.32","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70102-1"},{"key":"2025122511135784000_328.7437.434.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70290-3"},{"key":"2025122511135784000_328.7437.434.34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/bmj.1.5949.67","article-title":"Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.","volume":"1","author":"Szczeklik","year":"1975","journal-title":"BMJ"},{"key":"2025122511135784000_328.7437.434.35","first-page":"321","article-title":"Adverse reaction of acetaminophen as an alternative analgesic in AAS triad.","volume":"16","author":"Barles","year":"1988","journal-title":"Allergol Immunopathol (Madr)"},{"key":"2025122511135784000_328.7437.434.36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2165\/00003495-199300461-00065","article-title":"Oral challenge with alternative nonsteroidal antiinflammatory drugs (NSAIDs) and paracetamol in patients intolerant to these agents.","volume":"46","author":"Ispano","year":"1993","journal-title":"Drugs"},{"key":"2025122511135784000_328.7437.434.37","doi-asserted-by":"publisher","DOI":"10.1027\/0838-1925.12.4.171"},{"key":"2025122511135784000_328.7437.434.38","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.016003432.x"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.328.7437.434","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.328.7437.434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T19:14:05Z","timestamp":1766690045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.328.7437.434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,19]]},"references-count":38,"journal-issue":{"issue":"7437","published-online":{"date-parts":[[2004,2,19]]},"published-print":{"date-parts":[[2004,2,21]]}},"alternative-id":["10.1136\/bmj.328.7437.434"],"URL":"https:\/\/doi.org\/10.1136\/bmj.328.7437.434","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,19]]}}}