{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:08:35Z","timestamp":1792004915163,"version":"4.4.0"},"reference-count":25,"publisher":"BMJ","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To evaluate the relation between diagnosis of covid-19 with SARS-CoV-2 variant B.1.1.7 (also known as variant of concern 202012\/01) and the risk of hospital admission compared with diagnosis with wild-type SARS-CoV-2 variants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design<\/jats:title>\n            <jats:p>Retrospective cohort analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Setting<\/jats:title>\n            <jats:p>Community based SARS-CoV-2 testing in England, individually linked with hospital admission data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Participants<\/jats:title>\n            <jats:p>839\u2009278 patients with laboratory confirmed covid-19, of whom 36\u2009233 had been admitted to hospital within 14 days, tested between 23 November 2020 and 31 January 2021 and analysed at a laboratory with an available TaqPath assay that enables assessment of S-gene target failure (SGTF), a proxy test for the B.1.1.7 variant. Patient data were stratified by age, sex, ethnicity, deprivation, region of residence, and date of positive test.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Main outcome measures<\/jats:title>\n            <jats:p>Hospital admission between one and 14 days after the first positive SARS-CoV-2 test.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>27\u2009710 (4.7%) of 592\u2009409 patients with SGTF variants and 8523 (3.5%) of 246\u2009869 patients without SGTF variants had been admitted to hospital within one to 14 days. The stratum adjusted hazard ratio of hospital admission was 1.52 (95% confidence interval 1.47 to 1.57) for patients with covid-19 infected with SGTF variants, compared with those infected with non-SGTF variants. The effect was modified by age (P&lt;0.001), with hazard ratios of 0.93-1.21 in patients younger than 20 years with versus without SGTF variants, 1.29 in those aged 20-29, and 1.45-1.65 in those aged \u226530 years. The adjusted absolute risk of hospital admission within 14 days was 4.7% (95% confidence interval 4.6% to 4.7%) for patients with SGTF variants and 3.5% (3.4% to 3.5%) for those with non-SGTF variants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The results suggest that the risk of hospital admission is higher for people infected with the B.1.1.7 variant compared with wild-type SARS-CoV-2, likely reflecting a more severe disease. The higher severity may be specific to adults older than 30 years.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1136\/bmj.n1412","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T11:25:10Z","timestamp":1623756310000},"page":"n1412","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":105,"title":["Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-0626","authenticated-orcid":false,"given":"Tommy","family":"Nyberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Twohig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross J","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun R","family":"Seaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Flannagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Charlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"De Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Dabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Presanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"2021061508200744000_373.jun15_3.n1412.1","unstructured":"PANGO lineages. grinch: global report investigating novel coronavirus haplotypes: B.1.1.7. 2021. https:\/\/cov-lineages.org\/global_report_B.1.1.7.html."},{"key":"2021061508200744000_373.jun15_3.n1412.2","unstructured":"Public Health England. Investigation of variants of concern: technical briefing. 2021. https:\/\/www.gov.uk\/government\/publications\/investigation-of-novel-sars-cov-2-variant-variant-of-concern-20201201."},{"key":"2021061508200744000_373.jun15_3.n1412.3","unstructured":"UK Government Prime Minister\u2019s Office. Prime Minister announces national lockdown. 2021. https:\/\/www.gov.uk\/government\/news\/prime-minister-announces-national-lockdown."},{"key":"2021061508200744000_373.jun15_3.n1412.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03470-x"},{"key":"2021061508200744000_373.jun15_3.n1412.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg3055"},{"key":"2021061508200744000_373.jun15_3.n1412.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n579"},{"key":"2021061508200744000_373.jun15_3.n1412.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03426-1"},{"key":"2021061508200744000_373.jun15_3.n1412.8","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.11.2100256"},{"key":"2021061508200744000_373.jun15_3.n1412.9","doi-asserted-by":"crossref","unstructured":"Patone M Thomas K Hatch R . Analysis of severe outcomes associated with the SARS-CoV-2 Variant of Concern 202012\/01 in England using ICNARC Case Mix Programme and QResearch databases. medRxiv 2021.","DOI":"10.1101\/2021.03.11.21253364"},{"key":"2021061508200744000_373.jun15_3.n1412.10","doi-asserted-by":"crossref","unstructured":"Tuite AR, Fisman DN, Odutayo A, et al. COVID-19 Hospitalizations, ICU Admissions and Deaths Associated with the New Variants of Concern. 2021. https:\/\/covid19-sciencetable.ca\/sciencebrief\/covid-19-hospitalizations-icu-admissions-and-deaths-associated-with-the-new-variants-of-concern\/.","DOI":"10.47326\/ocsat.2021.02.18.1.0"},{"key":"2021061508200744000_373.jun15_3.n1412.11","unstructured":"Horby P, Bell I, Breuer J, et al. NERVTAG paper: Update note on B.1.1.7 severity. 2021. https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/961042\/S1095_NERVTAG_update_note_on_B.1.1.7_severity_20210211.pdf."},{"key":"2021061508200744000_373.jun15_3.n1412.12","unstructured":"Abbott S, Funk S. Population-level association between S-gene target failure and the relationship between cases, hospitalisations and deaths of Covid-19. 2021. https:\/\/github.com\/epiforecasts\/covid19.sgene.utla.rt\/blob\/main\/severity-report.pdf"},{"key":"2021061508200744000_373.jun15_3.n1412.13","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3802578"},{"key":"2021061508200744000_373.jun15_3.n1412.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2021.03.012"},{"key":"2021061508200744000_373.jun15_3.n1412.15","unstructured":"UK Government Department of Health and Social Care. NHS Test and Trace statistics (England): methodology. 2021. https:\/\/www.gov.uk\/government\/publications\/nhs-test-and-trace-statistics-england-methodology\/nhs-test-and-trace-statistics-england-methodology."},{"key":"2021061508200744000_373.jun15_3.n1412.16","unstructured":"NHS Digital. Secondary Uses Service (SUS). 2021. https:\/\/digital.nhs.uk\/services\/secondary-uses-service-sus."},{"key":"2021061508200744000_373.jun15_3.n1412.17","unstructured":"NHS Digital. Emergency Care Data Set (ECDS). 2021. https:\/\/digital.nhs.uk\/data-and-information\/data-collections-and-data-sets\/data-sets\/emergency-care-data-set-ecds."},{"key":"2021061508200744000_373.jun15_3.n1412.18","doi-asserted-by":"publisher","DOI":"10.1101\/2021.02.16.21251625"},{"key":"2021061508200744000_373.jun15_3.n1412.19","doi-asserted-by":"publisher","DOI":"10.3201\/eid2705.203524"},{"key":"2021061508200744000_373.jun15_3.n1412.20","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.06.20092957"},{"key":"2021061508200744000_373.jun15_3.n1412.21","unstructured":"Gov.uk. Coronavirus (COVID-19) in the UK. 2021. https:\/\/coronavirus.data.gov.uk\/."},{"key":"2021061508200744000_373.jun15_3.n1412.22","unstructured":"Office for National Statistics. Coronavirus (COVID-19) Infection Survey: characteristics of people testing positive for COVID-19 in England, 27 January 2021. 2021. https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/conditionsanddiseases\/articles\/coronaviruscovid19infectionsinthecommunityinengland\/characteristicsofpeopletestingpositiveforcovid19inengland27january2021#symptoms-profile-by-cases-com."},{"key":"2021061508200744000_373.jun15_3.n1412.23","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.16.2100348"},{"key":"2021061508200744000_373.jun15_3.n1412.24","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3792894"},{"key":"2021061508200744000_373.jun15_3.n1412.25","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00030-4"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.n1412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.n1412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T15:20:35Z","timestamp":1623770435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.n1412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":25,"alternative-id":["10.1136\/bmj.n1412"],"URL":"https:\/\/doi.org\/10.1136\/bmj.n1412","relation":{},"ISSN":["1756-1833"],"issn-type":[{"value":"1756-1833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]}}}