{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:53:19Z","timestamp":1787961199902,"version":"build-2784847793"},"reference-count":179,"publisher":"BMJ","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Atrial fibrillation is a common chronic disease seen in primary care offices, emergency departments, inpatient hospital services, and many subspecialty practices. Atrial fibrillation care is complicated and multifaceted, and, at various points, clinicians may see it as a consequence and cause of multi-morbidity, as a silent driver of stroke risk, as a bellwether of an acute medical illness, or as a primary rhythm disturbance that requires targeted treatment. Primary care physicians in particular must navigate these priorities, perspectives, and resources to meet the needs of individual patients. This includes judicious use of diagnostic testing, thoughtful use of novel therapeutic agents and procedures, and providing access to subspecialty expertise. This review explores the epidemiology, screening, and risk assessment of atrial fibrillation, as well as management of its symptoms (rate and various rhythm control options) and stroke risk (anticoagulation and other treatments), and offers a model for the integration of the components of atrial fibrillation care.<\/jats:p>","DOI":"10.1136\/bmj.n379","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T10:27:57Z","timestamp":1618223277000},"page":"n379","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Screening and management of atrial fibrillation in primary care"],"prefix":"10.1136","author":[{"given":"Shiva P","family":"Ponamgi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos C","family":"Siontis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Rushlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff-Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Montori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Noseworthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"2021041207250726000_373.apr12_2.n379.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"2021041207250726000_373.apr12_2.n379.2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019897870"},{"key":"2021041207250726000_373.apr12_2.n379.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.08.024"},{"key":"2021041207250726000_373.apr12_2.n379.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.063"},{"key":"2021041207250726000_373.apr12_2.n379.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.962688"},{"key":"2021041207250726000_373.apr12_2.n379.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192666"},{"key":"2021041207250726000_373.apr12_2.n379.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.03.003"},{"key":"2021041207250726000_373.apr12_2.n379.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.11.026"},{"key":"2021041207250726000_373.apr12_2.n379.9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.10.1118"},{"key":"2021041207250726000_373.apr12_2.n379.10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420130036007"},{"key":"2021041207250726000_373.apr12_2.n379.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.5.801"},{"key":"2021041207250726000_373.apr12_2.n379.12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"2021041207250726000_373.apr12_2.n379.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(19)32934-1"},{"key":"2021041207250726000_373.apr12_2.n379.14","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.2.316"},{"key":"2021041207250726000_373.apr12_2.n379.15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs469"},{"key":"2021041207250726000_373.apr12_2.n379.16","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000748"},{"key":"2021041207250726000_373.apr12_2.n379.17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2455"},{"key":"2021041207250726000_373.apr12_2.n379.18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"2021041207250726000_373.apr12_2.n379.19","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.1.M45"},{"key":"2021041207250726000_373.apr12_2.n379.20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510350050036"},{"key":"2021041207250726000_373.apr12_2.n379.21","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S47385"},{"key":"2021041207250726000_373.apr12_2.n379.22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.107.754564"},{"key":"2021041207250726000_373.apr12_2.n379.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.12.006"},{"key":"2021041207250726000_373.apr12_2.n379.24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.23.2851"},{"key":"2021041207250726000_373.apr12_2.n379.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.02.016"},{"key":"2021041207250726000_373.apr12_2.n379.26","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.224"},{"key":"2021041207250726000_373.apr12_2.n379.27","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-009-9411-x"},{"key":"2021041207250726000_373.apr12_2.n379.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01107-4"},{"key":"2021041207250726000_373.apr12_2.n379.29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1954"},{"key":"2021041207250726000_373.apr12_2.n379.30","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.107547"},{"key":"2021041207250726000_373.apr12_2.n379.31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.644484"},{"key":"2021041207250726000_373.apr12_2.n379.32","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu028"},{"key":"2021041207250726000_373.apr12_2.n379.33","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp235"},{"key":"2021041207250726000_373.apr12_2.n379.34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009035"},{"key":"2021041207250726000_373.apr12_2.n379.35","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv375"},{"key":"2021041207250726000_373.apr12_2.n379.36","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-315327"},{"key":"2021041207250726000_373.apr12_2.n379.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.028"},{"key":"2021041207250726000_373.apr12_2.n379.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.077"},{"key":"2021041207250726000_373.apr12_2.n379.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.08.043"},{"key":"2021041207250726000_373.apr12_2.n379.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.091"},{"key":"2021041207250726000_373.apr12_2.n379.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.053"},{"key":"2021041207250726000_373.apr12_2.n379.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.040"},{"key":"2021041207250726000_373.apr12_2.n379.43","unstructured":"King S, Fitzgerald A, Bartlett C, et al. The UK NSC recommendation on Atrial Fibrillation screening in adults. 2019. https:\/\/legacyscreening.phe.org.uk\/atrialfibrillation."},{"key":"2021041207250726000_373.apr12_2.n379.44","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31721-0"},{"key":"2021041207250726000_373.apr12_2.n379.45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808010"},{"key":"2021041207250726000_373.apr12_2.n379.46","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2016.0172"},{"key":"2021041207250726000_373.apr12_2.n379.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.06.1043"},{"key":"2021041207250726000_373.apr12_2.n379.48","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2018.0339"},{"key":"2021041207250726000_373.apr12_2.n379.49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311376"},{"key":"2021041207250726000_373.apr12_2.n379.50","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy045"},{"key":"2021041207250726000_373.apr12_2.n379.51","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026693"},{"key":"2021041207250726000_373.apr12_2.n379.52","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39280.660567.55"},{"key":"2021041207250726000_373.apr12_2.n379.53","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014343"},{"key":"2021041207250726000_373.apr12_2.n379.54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030583"},{"key":"2021041207250726000_373.apr12_2.n379.55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311376"},{"key":"2021041207250726000_373.apr12_2.n379.56","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv235"},{"key":"2021041207250726000_373.apr12_2.n379.57","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313600"},{"key":"2021041207250726000_373.apr12_2.n379.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.10.006"},{"key":"2021041207250726000_373.apr12_2.n379.59","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901183"},{"key":"2021041207250726000_373.apr12_2.n379.60","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316341"},{"key":"2021041207250726000_373.apr12_2.n379.61","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.4190"},{"key":"2021041207250726000_373.apr12_2.n379.62","first-page":"258","article-title":"CHADS2 versus CHA2DS2-VASc score in assessing the stroke and thromboembolism risk stratification in patients with atrial fibrillation: a systematic review and meta-analysis","volume":"10","author":"Chen","year":"2013","journal-title":"J Geriatr Cardiol"},{"key":"2021041207250726000_373.apr12_2.n379.63","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"2021041207250726000_373.apr12_2.n379.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"2021041207250726000_373.apr12_2.n379.65","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d124"},{"key":"2021041207250726000_373.apr12_2.n379.66","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.13"},{"key":"2021041207250726000_373.apr12_2.n379.67","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0134"},{"key":"2021041207250726000_373.apr12_2.n379.68","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.112.972869"},{"key":"2021041207250726000_373.apr12_2.n379.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.019"},{"key":"2021041207250726000_373.apr12_2.n379.70","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0608"},{"key":"2021041207250726000_373.apr12_2.n379.71","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I6A105"},{"key":"2021041207250726000_373.apr12_2.n379.72","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-12-0827"},{"key":"2021041207250726000_373.apr12_2.n379.73","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus305"},{"key":"2021041207250726000_373.apr12_2.n379.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.724"},{"key":"2021041207250726000_373.apr12_2.n379.75","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004259"},{"key":"2021041207250726000_373.apr12_2.n379.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.03.034"},{"key":"2021041207250726000_373.apr12_2.n379.77","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000078311.18928.16"},{"key":"2021041207250726000_373.apr12_2.n379.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.03.017"},{"key":"2021041207250726000_373.apr12_2.n379.79","first-page":"S31","article-title":"Evaluation of Time in Therapeutic Range in Anticoagulated Patients with Venous Thromboembolism: A Single-Center, Retrospective, Observational Study","volume":"141","author":"Zoubida","year":"2016","journal-title":"Thromb Res"},{"key":"2021041207250726000_373.apr12_2.n379.80","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.5.1155"},{"key":"2021041207250726000_373.apr12_2.n379.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.11.026"},{"key":"2021041207250726000_373.apr12_2.n379.82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198674"},{"key":"2021041207250726000_373.apr12_2.n379.83","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2158"},{"key":"2021041207250726000_373.apr12_2.n379.84","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309832"},{"key":"2021041207250726000_373.apr12_2.n379.85","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018905"},{"key":"2021041207250726000_373.apr12_2.n379.86","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2099"},{"key":"2021041207250726000_373.apr12_2.n379.87","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3189"},{"key":"2021041207250726000_373.apr12_2.n379.88","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"2021041207250726000_373.apr12_2.n379.89","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.11.084"},{"key":"2021041207250726000_373.apr12_2.n379.90","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"2021041207250726000_373.apr12_2.n379.91","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"2021041207250726000_373.apr12_2.n379.92","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"2021041207250726000_373.apr12_2.n379.93","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-590323"},{"key":"2021041207250726000_373.apr12_2.n379.94","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"2021041207250726000_373.apr12_2.n379.95","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13139"},{"key":"2021041207250726000_373.apr12_2.n379.96","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21917"},{"key":"2021041207250726000_373.apr12_2.n379.97","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.05.001"},{"key":"2021041207250726000_373.apr12_2.n379.98","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000477"},{"key":"2021041207250726000_373.apr12_2.n379.99","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306841"},{"key":"2021041207250726000_373.apr12_2.n379.100","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707278"},{"key":"2021041207250726000_373.apr12_2.n379.101","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607887"},{"key":"2021041207250726000_373.apr12_2.n379.102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300615"},{"key":"2021041207250726000_373.apr12_2.n379.103","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026793"},{"key":"2021041207250726000_373.apr12_2.n379.104","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035418"},{"key":"2021041207250726000_373.apr12_2.n379.105","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014113"},{"key":"2021041207250726000_373.apr12_2.n379.106","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.04.026"},{"key":"2021041207250726000_373.apr12_2.n379.107","doi-asserted-by":"publisher","DOI":"10.1053\/hj.1999.v137.91403"},{"key":"2021041207250726000_373.apr12_2.n379.108","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.14.1574"},{"key":"2021041207250726000_373.apr12_2.n379.109","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00813-9"},{"key":"2021041207250726000_373.apr12_2.n379.110","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1236"},{"key":"2021041207250726000_373.apr12_2.n379.111","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063479"},{"key":"2021041207250726000_373.apr12_2.n379.112","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"2021041207250726000_373.apr12_2.n379.113","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-7-199910050-00003"},{"key":"2021041207250726000_373.apr12_2.n379.114","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61343-X"},{"key":"2021041207250726000_373.apr12_2.n379.115","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"2021041207250726000_373.apr12_2.n379.116","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15192"},{"key":"2021041207250726000_373.apr12_2.n379.117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.010"},{"key":"2021041207250726000_373.apr12_2.n379.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.035"},{"key":"2021041207250726000_373.apr12_2.n379.119","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.025"},{"key":"2021041207250726000_373.apr12_2.n379.120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.515"},{"key":"2021041207250726000_373.apr12_2.n379.121","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.1371"},{"key":"2021041207250726000_373.apr12_2.n379.122","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003074"},{"key":"2021041207250726000_373.apr12_2.n379.123","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.006418"},{"key":"2021041207250726000_373.apr12_2.n379.124","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000067"},{"key":"2021041207250726000_373.apr12_2.n379.125","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03230-X"},{"key":"2021041207250726000_373.apr12_2.n379.126","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021328"},{"key":"2021041207250726000_373.apr12_2.n379.127","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.041"},{"key":"2021041207250726000_373.apr12_2.n379.128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.038"},{"key":"2021041207250726000_373.apr12_2.n379.129","first-page":"132","article-title":"Safety and tolerability of beta-blockers: prejudices & reality","volume":"62","author":"Erdmann","year":"2010","journal-title":"Indian Heart J"},{"key":"2021041207250726000_373.apr12_2.n379.130","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/17.suppl_C.48"},{"key":"2021041207250726000_373.apr12_2.n379.131","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2019422"},{"key":"2021041207250726000_373.apr12_2.n379.132","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89119-9"},{"key":"2021041207250726000_373.apr12_2.n379.133","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103213241201"},{"key":"2021041207250726000_373.apr12_2.n379.134","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00275-1"},{"key":"2021041207250726000_373.apr12_2.n379.135","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.19.2385"},{"key":"2021041207250726000_373.apr12_2.n379.136","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003303421302"},{"key":"2021041207250726000_373.apr12_2.n379.137","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.12.1741"},{"key":"2021041207250726000_373.apr12_2.n379.138","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.3.572"},{"key":"2021041207250726000_373.apr12_2.n379.139","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391003"},{"key":"2021041207250726000_373.apr12_2.n379.140","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"2021041207250726000_373.apr12_2.n379.141","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"2021041207250726000_373.apr12_2.n379.142","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.12.047"},{"key":"2021041207250726000_373.apr12_2.n379.143","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3934.939"},{"key":"2021041207250726000_373.apr12_2.n379.144","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2006.03.005"},{"key":"2021041207250726000_373.apr12_2.n379.145","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-2240(70)80089-X"},{"key":"2021041207250726000_373.apr12_2.n379.146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.064"},{"key":"2021041207250726000_373.apr12_2.n379.147","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw285"},{"key":"2021041207250726000_373.apr12_2.n379.148","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv057"},{"key":"2021041207250726000_373.apr12_2.n379.149","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12695"},{"key":"2021041207250726000_373.apr12_2.n379.150","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62039-9"},{"key":"2021041207250726000_373.apr12_2.n379.151","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00194"},{"key":"2021041207250726000_373.apr12_2.n379.152","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.21187"},{"key":"2021041207250726000_373.apr12_2.n379.153","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(20)33732-3"},{"key":"2021041207250726000_373.apr12_2.n379.154","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042622"},{"key":"2021041207250726000_373.apr12_2.n379.155","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"2021041207250726000_373.apr12_2.n379.156","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.10.003"},{"key":"2021041207250726000_373.apr12_2.n379.157","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.21.2634"},{"key":"2021041207250726000_373.apr12_2.n379.158","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.467"},{"key":"2021041207250726000_373.apr12_2.n379.159","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup122"},{"key":"2021041207250726000_373.apr12_2.n379.160","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.002366"},{"key":"2021041207250726000_373.apr12_2.n379.161","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707855"},{"key":"2021041207250726000_373.apr12_2.n379.162","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.008128"},{"key":"2021041207250726000_373.apr12_2.n379.163","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa055"},{"key":"2021041207250726000_373.apr12_2.n379.164","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310952"},{"key":"2021041207250726000_373.apr12_2.n379.165","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.11.033"},{"key":"2021041207250726000_373.apr12_2.n379.166","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817591"},{"key":"2021041207250726000_373.apr12_2.n379.167","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"2021041207250726000_373.apr12_2.n379.168","first-page":"2189","article-title":"Amiodarone: guidelines for use and monitoring","volume":"68","author":"Siddoway","year":"2003","journal-title":"Am Fam Physician"},{"key":"2021041207250726000_373.apr12_2.n379.169","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014932"},{"key":"2021041207250726000_373.apr12_2.n379.170","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.01.052"},{"key":"2021041207250726000_373.apr12_2.n379.171","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.08.030"},{"key":"2021041207250726000_373.apr12_2.n379.172","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1109283"},{"key":"2021041207250726000_373.apr12_2.n379.173","unstructured":"Institute of Medicine (US) Committee on Quality of Health Care in America . Crossing the Quality Chasm: A New Health System for the 21st Century. National Academies Press, 2001."},{"key":"2021041207250726000_373.apr12_2.n379.174","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv448"},{"key":"2021041207250726000_373.apr12_2.n379.175","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.04.039"},{"key":"2021041207250726000_373.apr12_2.n379.176","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"2021041207250726000_373.apr12_2.n379.177","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.021"},{"key":"2021041207250726000_373.apr12_2.n379.178","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008718"},{"key":"2021041207250726000_373.apr12_2.n379.179","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613773"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.n379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.n379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T14:28:15Z","timestamp":1618237695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.n379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":179,"alternative-id":["10.1136\/bmj.n379"],"URL":"https:\/\/doi.org\/10.1136\/bmj.n379","relation":{},"ISSN":["1756-1833"],"issn-type":[{"value":"1756-1833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]}}}