{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:29:09Z","timestamp":1787696949517,"version":"build-2784847793"},"reference-count":29,"publisher":"BMJ","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To determine whether discontinuing oxytocin stimulation in the active phase of induced labour is associated with lower caesarean section rates.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design<\/jats:title>\n            <jats:p>International multicentre, double blind, randomised controlled trial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Setting<\/jats:title>\n            <jats:p>Nine hospitals in Denmark and one in the Netherlands between 8 April 2016 and 30 June 2020.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Participants<\/jats:title>\n            <jats:p>1200 women stimulated with intravenous oxytocin infusion during the latent phase of induced labour.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Intervention<\/jats:title>\n            <jats:p>Women were randomly assigned to have their oxytocin stimulation discontinued or continued in the active phase of labour.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Main outcome measure<\/jats:title>\n            <jats:p>Delivery by caesarean section.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              A total of 607 women were assigned to discontinuation and 593 to continuation of the oxytocin infusion. The rates of caesarean section were 16.6% (n=101) in the discontinued group and 14.2% (n=84) in the continued group (relative risk 1.17, 95% confidence interval 0.90 to 1.53). In 94 parous women with no previous caesarean section, the caesarean section rate was 7.5% (11\/147) in the discontinued group and 0.6% (1\/155)\n              <jats:bold\/>\n              in the continued group (relative risk 11.6, 1.15 to 88.7). Discontinuation was associated with longer duration of labour (median from randomisation to delivery 282\n              <jats:italic>v<\/jats:italic>\n              201 min; P&lt;0.001), a reduced risk of hyperstimulation (20\/546 (3.7%)\n              <jats:italic>v<\/jats:italic>\n              70\/541 (12.9%); P&lt;0.001), and a reduced risk of fetal heart rate abnormalities (153\/548 (27.9%)\n              <jats:italic>v<\/jats:italic>\n              219\/537 (40.8%); P&lt;0.001) but rates of other adverse maternal and neonatal outcomes were similar between groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In a setting where monitoring of the fetal condition and the uterine contractions can be guaranteed, routine discontinuation of oxytocin stimulation may lead to a small increase in caesarean section rate but a significantly reduced risk of uterine hyperstimulation and abnormal fetal heart rate patterns.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>\n              ClinicalTrials.gov\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT02553226\" ext-link-type=\"clintrialgov\">NCT02553226<\/jats:ext-link>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1136\/bmj.n716","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:05:23Z","timestamp":1618445123000},"page":"n716","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Continued versus discontinued oxytocin stimulation in the active phase of labour (CONDISOX): double blind randomised controlled trial"],"prefix":"10.1136","clinical-trial-number":[{"clinical-trial-number":"nct02553226","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-2117","authenticated-orcid":false,"given":"Sidsel","family":"Boie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Glavind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Uldbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Steer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Bor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"2021041421000632000_373.apr14_6.n716.1","first-page":"1","article-title":"Births: Final Data for 2018","volume":"68","author":"Martin","year":"2019","journal-title":"Natl Vital Stat Rep"},{"key":"2021041421000632000_373.apr14_6.n716.2","unstructured":"World Health Organization. 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