{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T05:24:52Z","timestamp":1678339492652},"reference-count":3,"publisher":"BMJ","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ"],"DOI":"10.1136\/bmj.o2301","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T12:25:15Z","timestamp":1663935915000},"page":"o2301","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Motor neuron disease treatment misses primary endpoint but reports benefits within a year"],"prefix":"10.1136","author":[{"given":"Elisabeth","family":"Mahase","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"2023030808293508000_378.sep23_7.o2301.1","unstructured":"Trial of antisense oligonucleotide tofersen for SOD1 ALS. NEJM. 2022. www.nejm.org\/doi\/full\/10.1056\/NEJMoa2204705"},{"key":"2023030808293508000_378.sep23_7.o2301.2","unstructured":"FDA accepts Biogen\u2019s new drug application and grants priority review of tofersen for a rare, genetic form of ALS. https:\/\/investors.biogen.com\/news-releases\/news-release-details\/fda-accepts-biogens-new-drug-application-and-grants-priority."},{"key":"2023030808293508000_378.sep23_7.o2301.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1462"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.o2301","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.o2301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T17:38:24Z","timestamp":1678297104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.o2301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":3,"alternative-id":["10.1136\/bmj.o2301"],"URL":"https:\/\/doi.org\/10.1136\/bmj.o2301","relation":{},"ISSN":["1756-1833"],"issn-type":[{"value":"1756-1833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]}}}