{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:58Z","timestamp":1790776618390,"version":"4.1.0"},"reference-count":6,"publisher":"BMJ","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ"],"abstract":"<jats:title>The study<\/jats:title>\n          <jats:p>\n            Vinogradova Y, Coupland C, Hippisley-Cox J. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases.\n            <jats:italic>BMJ<\/jats:italic>\n            2020;371:m3873.\n          <\/jats:p>\n          <jats:p>\n            To read the full NIHR Alert, go to:\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/evidence.nihr.ac.uk\/alert\/risk-of-breast-cancer-with-hrt-depends-therapy-type-and-duration\/\">https:\/\/evidence.nihr.ac.uk\/alert\/risk-of-breast-cancer-with-hrt-depends-therapy-type-and-duration\/<\/jats:ext-link>\n          <\/jats:p>","DOI":"10.1136\/bmj.o485","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T16:27:21Z","timestamp":1646756841000},"page":"o485","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Risk of breast cancer with HRT depends on therapy type and duration"],"prefix":"10.1136","author":[{"given":"Helen","family":"Saul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Gursul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Vinogradova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"2022030807501491000_376.mar08_4.o485.1","first-page":"10204","article-title":"Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence","volume":"394","year":"2019","journal-title":"Lancet"},{"key":"2022030807501491000_376.mar08_4.o485.2","first-page":"9382","article-title":"Breast cancer and hormone-replacement therapy in the Million Women Study","volume":"362","year":"2003","journal-title":"Lancet"},{"key":"2022030807501491000_376.mar08_4.o485.3","unstructured":"National Institute for Health and Care Excellence. Guidance on diagnosing and managing menopause. NICE guideline [NG23] 2019. https:\/\/www.nice.org.uk\/guidance\/ng23"},{"key":"2022030807501491000_376.mar08_4.o485.4","unstructured":"Bithell C. HRT and breast cancer risk. Blog post from the Institute of Cancer Research. https:\/\/www.icr.ac.uk\/blogs\/science-talk\/page-details\/what-should-women-know-about-the-new-hrt-and-breast-cancer-study"},{"key":"2022030807501491000_376.mar08_4.o485.5","unstructured":"Institute of Cancer Research. Effect of combined HRT on breast cancer risk likely to have been underestimated, new study finds. https:\/\/www.icr.ac.uk\/news-archive\/effect-of-combined-hrt-on-breast-cancer-risk-likely-to-have-been-underestimated-new-study-finds"},{"key":"2022030807501491000_376.mar08_4.o485.6","unstructured":"Breast Cancer Now. The Breast Cancer Now Generations Study. https:\/\/breastcancernow.org\/breast-cancer-research\/research-projects\/our-research-projects\/breast-cancer-now-generations-study"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.o485","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.o485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T16:27:22Z","timestamp":1646756842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.o485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":6,"alternative-id":["10.1136\/bmj.o485"],"URL":"https:\/\/doi.org\/10.1136\/bmj.o485","relation":{},"ISSN":["1756-1833"],"issn-type":[{"value":"1756-1833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]}}}