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High sensitivity cardiac troponins (hs-cTn) are the preferred biomarkers for diagnosing acute myocardial infarction, allowing for more accurate detection and exclusion of myocardial injury. However, elevations in hs-cTn can occur in patients who are not experiencing acute myocardial infarction. Therefore, it is important for clinicians to recognize how to integrate hs-cTn levels into their clinical decision making process. Structured risk assessments, using evidence based diagnostic protocols, should be employed to estimate the risk of acute coronary syndrome and adverse events in patients with chest pain. Clinical decision pathways should be used routinely in emergency departments. Patients at intermediate or high risk of obstructive coronary artery disease might benefit from cardiac imaging and further testing. Patients should be involved in decision making, with information provided about risks, radiation exposure, costs, and alternative options to facilitate informed decision making.<\/jats:p>","DOI":"10.1136\/bmj.r136","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T05:00:37Z","timestamp":1743310837000},"page":"r136","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluating patients with chest pain in the emergency department"],"prefix":"10.1136","author":[{"given":"Fernanda","family":"Bellolio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Body","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P","family":"Than","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik P","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"2025032922000914000_388.mar28_4.r136.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001029"},{"key":"2025032922000914000_388.mar28_4.r136.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.079"},{"key":"2025032922000914000_388.mar28_4.r136.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.001384"},{"key":"2025032922000914000_388.mar28_4.r136.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036528"},{"key":"2025032922000914000_388.mar28_4.r136.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.08.009"},{"key":"2025032922000914000_388.mar28_4.r136.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.11.003"},{"key":"2025032922000914000_388.mar28_4.r136.7","doi-asserted-by":"crossref","unstructured":"Cairns C, Kang K. 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