{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:34:26Z","timestamp":1774319666032,"version":"3.50.1"},"reference-count":41,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Diab Res Care"],"accepted":{"date-parts":[[2016,11,14]]},"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine prevalences and predictors of undiagnosed diabetes mellitus (UDM) and impaired fasting glucose (IFG) in non-Hispanic whites with <jats:italic>HFE<\/jats:italic> p.C282Y homozygosity and controls without common <jats:italic>HFE<\/jats:italic> mutations identified in population screening.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Research design and methods<\/jats:title>\n                  <jats:p>We analyzed these observations in a postscreening examination: age; sex; body mass index; systolic\/diastolic blood pressure; metacarpophalangeal joint hypertrophy; hepatomegaly; blood neutrophils; alanine and aspartate aminotransferase; elevated C reactive protein; transferrin saturation; serum ferritin; and Field Center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 223 p.C282Y homozygotes and 449 controls without diagnosed diabetes (43.9% men). Mean age of p.C282Y homozygotes was 52\u00b113\u2005years (controls 57\u00b114\u2005years; p&lt;0.0001). Mean transferrin saturation in p.C282Y homozygotes was 67\u00b126% (controls 34\u00b114%; p&lt;0.0001). Mean serum ferritin in p.C282Y homozygotes was 607\u2005pmol\/L (95% CI 497 to 517; controls 274\u2005pmol\/L (247 to 301); p&lt;0.0001). Overall prevalences of UDM (4.0% vs 4.2%) and IFG (23.8% vs 25.6%) did not differ significantly between p.C282Y homozygotes and wt\/wt controls, respectively. In logistic regressions, male sex, body mass index, and alanine aminotransferase were significantly associated with UDM. ORs were 2.7 (1.2 to 2.8); 1.0 (1.0 to 1.1); and 1.0 (1.0 to 1.0), respectively. Age, male sex, and body mass index were significantly associated with IFG. ORs were 1.0 (1.0 to 1.1); 2.8 (1.9 to 4.2); and 1.0 (1.0 to 1.1), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Prevalences of UDM and IFG were similar in p.C282Y homozygotes and controls in a postpopulation screening examination. Male sex was the strongest predictor of UDM and IFG.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjdrc-2016-000278","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T21:00:26Z","timestamp":1482958826000},"page":"e000278","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Undiagnosed diabetes and impaired fasting glucose in <i>HFE<\/i> C282Y homozygotes and <i>HFE<\/i> wild-type controls in the HEIRS Study"],"prefix":"10.1136","volume":"4","author":[{"given":"James C","family":"Barton","sequence":"first","affiliation":[{"name":"Southern Iron Disorders Center, Birmingham, Alabama, USA"},{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Clayborn","family":"Barton","sequence":"additional","affiliation":[{"name":"Southern Iron Disorders Center, Birmingham, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald T","family":"Acton","sequence":"additional","affiliation":[{"name":"Southern Iron Disorders Center, Birmingham, Alabama, USA"},{"name":"Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"2025073111394914000_4.1.e000278.1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1399-0004.1974.tb01688.x","article-title":"Idiopathic haemochromatosis: an autosomal recessive disease","volume":"5","author":"Saddi","year":"1974","journal-title":"Clin Genet"},{"key":"2025073111394914000_4.1.e000278.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805263182103"},{"key":"2025073111394914000_4.1.e000278.3","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"2025073111394914000_4.1.e000278.4","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2005.9.231"},{"key":"2025073111394914000_4.1.e000278.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261875"},{"key":"2025073111394914000_4.1.e000278.6","unstructured":"Edwards CQ , Barton JC . 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