{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:38:29Z","timestamp":1761676709418,"version":"3.41.2"},"reference-count":27,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Diab Res Care"],"accepted":{"date-parts":[[2018,12,28]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine whether serum adiponectin and orosomucoid were associated with postload glucose \u226470\u2009mg\/dL during an oral glucose tolerance test (OGTT), termed as postload low glycemia, a possible inverse marker for dysglycemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Research design and methods<\/jats:title>\n                  <jats:p>75\u2009g OGTTs were performed with multiple postload glucose and insulin measurements over a 30\u2013120\u2009min period in 168 normal-weight Japanese women (18\u201324 years). Insulin resistance (IR) and \u03b2-cell function inferred from serum insulin kinetics during OGTT, fat mass and distribution by dual-energy X-ray absorptiometry (DXA), serum adiponectin and inflammatory markers were compared cross-sectionally between 39 women with and 129 women without postload low glycemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 168 women, 161 had normal glucose tolerance. Women with as compared with those without postload low glycemia had lower fasting and postload glycemia despite similar fasting and postload insulinemia. They had higher insulinogenic index (p=0.03) and lower adipose IR (a product of fasting free fatty acid and insulin, p=0.01), although DXA-derived general and central adiposity, the Matsuda Index and homeostasis model assessment-IR did not differ. In addition, they had higher adiponectin and lower orosomucoid (both p&lt;0.001). Multivariate logistic regression analyses revealed that adiponectin (OR: 1.14, 95% CI 1.03 to 1.26, p=0.009) and orosomucoid (0.96, 0.93 to 0.97, p=0.008) were associated with postload low glycemia independently of adipose IR and insulinogenic index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Higher adiponectin and lower orosomucoid were associated with 70 or lower mg\/dL of postload glucose, a possible inverse marker for dysglycemia, in young women independently of DXA-derived fat mass and distribution, insulin secretion and IR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjdrc-2018-000596","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T08:42:45Z","timestamp":1549615365000},"page":"e000596","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Higher circulating adiponectin and lower orosomucoid were associated with postload glucose \u226470 mg\/dL, a possible inverse marker for dysglycemia, in young Japanese women"],"prefix":"10.1136","volume":"7","author":[{"given":"Ayaka","family":"Tsuboi","sequence":"first","affiliation":[{"name":"Research Institute for Nutrition Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, Japan"},{"name":"Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Minato","sequence":"additional","affiliation":[{"name":"Research Institute for Nutrition Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, Japan"},{"name":"Graduate School of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumu","family":"Yano","sequence":"additional","affiliation":[{"name":"Research Institute for Nutrition Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Research Institute for Nutrition Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, Japan"},{"name":"Department of Nutritional Sciences for Well-Being, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Kashiwara, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Kurata","sequence":"additional","affiliation":[{"name":"Research Institute for Nutrition Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, Japan"},{"name":"Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Diabetes Center, Shinsuma Hospital, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women\u2019s University Diabetes Division, Nishinomiya, Japan"},{"name":"Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Kazumi","sequence":"additional","affiliation":[{"name":"Research Institute for Nutrition Sciences, Mukogawa Women\u2019s University, Nishinomiya, Hyogo, 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