{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:35:43Z","timestamp":1780925743387,"version":"3.54.1"},"reference-count":33,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Diab Res Care"],"accepted":{"date-parts":[[2019,11,26]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Research design and methods<\/jats:title>\n                  <jats:p>In this double-blind, randomized clinical trial, a total of 42 patients with chronic periodontitis and type 2 diabetes were included. Patients were randomly assigned to treatment with either clindamycin or amoxicillin-metronidazole three times a day during 7\u2009days. Clinical determinations (probing depth, bleeding on probe, and plaque index) were performed to determine the extent and severity of periodontitis before and after the pharmacological treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After 7\u2009days of administration of clindamycin or amoxicillin-metronidazole, no differences were observed between the clinical determinations, probing depth (0.44 vs 0.50\u2009mm, p=0.624), plaque index (17.62 vs 15.88%, p=0.910), and bleeding on probing (16.12 vs 22.17%, p=0.163), respectively. There were no adverse events in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The administration during 7\u2009days of clindamycin or amoxicillin\/metronidazole showed the same efficacy for the reduction of probing depth, plaque index, and bleeding on probing in patients with periodontitis and type 2 diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjdrc-2019-000665","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T10:07:46Z","timestamp":1579601266000},"page":"e000665","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial"],"prefix":"10.1136","volume":"8","author":[{"given":"Juan Ram\u00f3n","family":"G\u00f3mez-Sandoval","sequence":"first","affiliation":[{"name":"Departamento de Cl\u00ednicas Odontol\u00f3gicas Integrales, Instituto de Invesigaci\u00f3n en Odontolog\u00eda, Especialidad en Periodoncia, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Robles-Cervantes","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Instituto Jalisciense de Cirug\u00eda Reconstructiva, Secretar\u00eda de Salud Jalisco, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Ofelia","family":"Hern\u00e1ndez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica 02 y Divisi\u00f3n de Investigaci\u00f3n en Salud, Unidad M\u00e9dica de Alta Especialidad Hospital de Especialidades, Centro M\u00e9dico Nacional de 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Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vianeth","family":"Mart\u00ednez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Odontol\u00f3gicas Integrales, Instituto de Invesigaci\u00f3n en Odontolog\u00eda, Especialidad en Periodoncia, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Celia","family":"Morgado-Castillo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica 02 y Divisi\u00f3n de Investigaci\u00f3n en Salud, Unidad M\u00e9dica de Alta Especialidad Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico"},{"name":"Diabetes sin Complicaciones S.A de C.V, Zapopan, Jalisco, 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