{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:08:35Z","timestamp":1794244115227,"version":"4.9.0"},"reference-count":51,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Diab Res Care"],"accepted":{"date-parts":[[2019,7,8]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Daily remote foot temperature monitoring is an evidence-based preventive practice for patients at risk for diabetic foot complications. Unfortunately, the conventional approach requires comparison of temperatures between contralaterally matched anatomy, limiting practice in high-risk cohorts such as patients with a wound to one foot and those with proximal lower extremity amputation (LEA). We developed and assessed a novel approach for monitoring of a single foot for the prevention and early detection of diabetic foot complications. The purpose of this study was to assess the sensitivity, specificity, and lead time associated with unilateral diabetic foot temperature monitoring.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Research design and methods<\/jats:title>\n                  <jats:p>We used comparisons among ipsilateral foot temperatures and between foot temperatures and ambient temperature as a marker of inflammation. We analyzed data collected from a 129-participant longitudinal study to evaluate the predictive accuracy of our approach. To evaluate classification accuracy, we constructed a receiver operator characteristic curve and reported sensitivity, specificity, and lead time for four different monitoring settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Using this approach, monitoring a single foot was found to predict 91% of impending non-acute plantar foot ulcers on average 41 days before clinical presentation with a resultant mean 4.2 alerts per participant-year. By adjusting the threshold temperature setting, the specificity could be increased to 78% with corresponding reduced sensitivity of 53%, lead time of 33 days, and 2.2 alerts per participant-year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Given the high incidence of subsequent diabetic foot complications to the sound foot in patients with a history of proximal LEA and patients being treated for a wound, practice of daily temperature monitoring of a single foot has the potential to significantly improve outcomes and reduce resource utilization in this challenging high-risk population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjdrc-2019-000696","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T07:19:02Z","timestamp":1565162342000},"page":"e000696","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Unilateral remote temperature monitoring to predict future ulceration for the diabetic foot in remission"],"prefix":"10.1136","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct02647346","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Lawrence A","family":"Lavery","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-5859","authenticated-orcid":false,"given":"Brian J","family":"Petersen","sequence":"additional","affiliation":[{"name":"Podimetrics, Inc, Somerville, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Linders","sequence":"additional","affiliation":[{"name":"Podimetrics, Inc, Somerville, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Bloom","sequence":"additional","affiliation":[{"name":"Podimetrics, Inc, Somerville, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"key":"2025073113045778000_7.1.e000696.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"2025073113045778000_7.1.e000696.2","unstructured":"Boulton AJM , Armstrong DG , Kirsner RS , et al . 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