{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:29:23Z","timestamp":1791851363179,"version":"4.3.4"},"reference-count":26,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Diab Res Care"],"accepted":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Serum calcification propensity is emerging as an independent predictor for cardiovascular outcomes in high-risk populations. Calcification propensity can be monitored by the maturation time of calciprotein particles in serum (T<jats:sub>50<\/jats:sub> test). A low T<jats:sub>50<\/jats:sub> value is an independent determinant of cardiovascular morbidity and mortality in various populations. Aim was to investigate the T<jats:sub>50<\/jats:sub> and its relationship to type 2 diabetes mellitus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Research design and methods<\/jats:title>\n                  <jats:p>Using nephelometry, serum T<jats:sub>50<\/jats:sub> was cross-sectionally measured in 932 stable patients with type 2 diabetes mellitus (55% male) with a median age of 66 (62\u201375) years, diabetes duration of 6.5 (3.0\u201310.2) years and hemoglobin A1c (HbA1c) of 49 (44\u201354) mmol\/mol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Serum T<jats:sub>50<\/jats:sub> was normally distributed with a mean value of 261\u00b166\u2009min. In linear regression, serum T<jats:sub>50<\/jats:sub> was lower in women and current smokers. A lower T<jats:sub>50<\/jats:sub> value was found in patients with a higher HbA1c or higher systolic blood pressure, insulin users and patients with a longer history of diabetes. The association with HbA1c was independent of other determinants in multivariable analysis. There was no association between T<jats:sub>50<\/jats:sub> and previous macrovascular events or the presence of microvascular disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Serum calcification propensity is independently associated with glycemic control, suggesting that a lower HbA1c may be associated with better cardiovascular outcomes. Retrospective analysis could not establish an association between a history of macrovascular events and T<jats:sub>50<\/jats:sub>, and prospective studies will have to be performed to address this hypothesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT01570140\">NCT01570140<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjdrc-2020-002016","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T11:14:06Z","timestamp":1614165246000},"page":"e002016","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Serum calcification propensity is associated with HbA1c in type 2 diabetes mellitus"],"prefix":"10.1136","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct01570140","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Rik","family":"Mencke","sequence":"first","affiliation":[{"name":"Department of Pathology and Medical Biology \u2013 Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarens","family":"van der Vaart","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology \u2013 Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[{"name":"Calciscon AG, Nidau, 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