{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:07:15Z","timestamp":1793995635330,"version":"4.8.0"},"reference-count":30,"publisher":"BMJ","issue":"6","funder":[{"name":"Thai Traditional and Alternative Medicine Fund","award":["3-2561"],"award-info":[{"award-number":["3-2561"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ EBM"],"accepted":{"date-parts":[[2023,7,10]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of curcumin versus omeprazole in improving patient reported outcomes in people with dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised, double blind controlled trial, with central randomisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Thai traditional medicine hospital, district hospital, and university hospitals in Thailand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Participants with a diagnosis of functional dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>The interventions were curcumin alone (C), omeprazole alone (O), or curcumin plus omeprazole (C+O). Patients in the combination group received two capsules of 250\u2009mg curcumin, four times daily, and one capsule of 20\u2009mg omeprazole once daily for 28 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Functional dyspepsia symptoms on days 28 and 56 were assessed using the Severity of Dyspepsia Assessment (SODA) score. Secondary outcomes were the occurrence of adverse events and serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>206 patients were enrolled in the study and randomly assigned to one of the three groups; 151 patients completed the study. Demographic data (age 49.7\u00b111.9 years; women 73.4%), clinical characteristics and baseline dyspepsia scores were comparable between the three groups. Significant improvements were observed in SODA scores on day 28 in the pain (\u22124.83, \u20135.46 and \u22126.22), non-pain (\u22122.22, \u20132.32 and \u22122.31) and satisfaction (0.39, 0.79 and 0.60) categories for the C+O, C, and O groups, respectively. These improvements were enhanced on day 56 in the pain (\u22127.19, \u20138.07 and \u22128.85), non-pain (\u22124.09, \u20134.12 and \u22123.71) and satisfaction (0.78, 1.07, and 0.81) categories in the C+O, C, and O groups, respectively. No significant differences were observed among the three groups and no serious adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No discernible differences were identified between curcumin and omeprazole in their efficacy for the functional treatment of dyspepsia, and no apparent synergistic effect was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p>TCTR20221208003.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjebm-2022-112231","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:18Z","timestamp":1694476818000},"page":"400-407","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled 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