{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:29:16Z","timestamp":1754162956100,"version":"3.41.2"},"reference-count":20,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Gastroenterol"],"accepted":{"date-parts":[[2014,7,23]]},"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Idiopathic hypercalciuria is characterised by renal stone formation and vertebral osteoporosis. The syndrome displays high clinical variability with patients almost equally distributed between fasting or renal type (prevalent calcium loss) and absorptive type (prevalent increase of intestinal absorption). Absorptive hypercalciuria (AH) is characterised by hypersensitivity of calcium-sensing receptors of antral G cells with normal fasting gastrinaemia and meal hypergastrinaemia. To the best of our knowledge, no study has been published about the morphological aspects of gastric biopsies of patients with AH and the immunohistochemical findings of gastrin-producing G cells. So we studied morphologically and immunohistochemically a group of 38 patients with AH, describing their gastric findings and associated lesion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>All 38 patients had a clinical-laboratory diagnosis of AH with normal fasting hypergastrinaemia and an abnormal rise of gastrinaemia after a standardised meal test. Their 38 antral and 27 body-fundus biopsies, and 5 normal antral and body controls, were stained with H&amp;E, Giemsa stain, polyclonal antiserum anti-Gastrin and a monoclonal antibody anti-Chromogranin A.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Antral biopsies of all 38 patients showed a simple (15) or linear (23) hyperplasia of G cells, whereas only 2 of 27 body biopsies showed a nodular hyperplasia of endocrine cells. In five patients with AH, we found an association with fundic gland polyps (FGPs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found in all of the patients with AH a correlation between meal hypergastrinaemia and morphological antral G-cell hyperplasia. Moreover, in five patients, AH was associated with FGPs. We know from literature data that FGPs\u2019 development in Zollinger-Ellison syndrome is statistically associated with hypergastrinaemia. From our present data, we suggest that even in AH the stimulated hypergastrinaemia may have a role in polyp development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjgast-2014-000004","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T07:50:06Z","timestamp":1409903406000},"page":"e000004","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["The morphological and immunohistochemical spectrum of gastric biopsies of patients with absorptive hypercalciuria"],"prefix":"10.1136","volume":"1","author":[{"given":"Paolo","family":"Declich","sequence":"first","affiliation":[{"name":"Department of Pathology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Belloni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Tavani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Omazzi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bellone","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Bortoli","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Arena","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Devani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rho Hospital, Rho, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2025073013073529000_1.1.e000004.1","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/01.ASN.0000062960.26868.17","article-title":"Molecular mechanisms of primary hypercalciuria","volume":"14","author":"Frick","year":"2003","journal-title":"J Am Nephrol"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.2","DOI":"10.1210\/jc.2004-0045"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.3","DOI":"10.1073\/pnas.1009078107"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.4","DOI":"10.1159\/000199786"},{"key":"2025073013073529000_1.1.e000004.5","first-page":"283","article-title":"Antral G-cells in sporadic fundic gland polyps patients: an immunohistochemical study","volume":"443","author":"Declich","year":"2003","journal-title":"Virchows Arch"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.6","DOI":"10.1136\/gutjnl-2012-304100"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.7","DOI":"10.1097\/01.MP.0000062995.72390.14"},{"key":"2025073013073529000_1.1.e000004.8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-0028-1104862","article-title":"Dr\u00fcsenk\u00f6rperzysten, eine polypoide l\u00e4sion der magenschleimhaut","volume":"102","author":"Elster","year":"1977","journal-title":"Dtsch Med Wschr"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.9","DOI":"10.1093\/ajcp\/86.4.498"},{"key":"2025073013073529000_1.1.e000004.10","first-page":"3","article-title":"Fundic gland polyps: a still elusive entity on the eve of the year 2000","volume":"51","author":"Declich","year":"2000","journal-title":"Pol J Pathol"},{"key":"2025073013073529000_1.1.e000004.11","first-page":"131","article-title":"Sporadic fundic gland polyps: clinico-pathologic features and associated diseases","volume":"56","author":"Declich","year":"2005","journal-title":"Pol J Pathol"},{"unstructured":"Dayal Y , Wolfe HJ . Hyperplastic proliferations of the gastrointestinal endocrine cells. In: Dayal Y . ed. Endocrine pathology of the gut and pancreas. Boca Raton: CRC Press, 1991:34\u201342.","key":"2025073013073529000_1.1.e000004.12"},{"key":"2025073013073529000_1.1.e000004.13","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.3748\/wjg.v11.i27.4140","article-title":"Gastrin and antral G cells in course of Helicobacter pylori eradication: six months follow up study","volume":"11","author":"Sokic-Milutinovic","year":"2005","journal-title":"World J Gastroenterol"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.14","DOI":"10.1016\/S0046-8177(00)80213-0"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.15","DOI":"10.1016\/S0046-8177(78)80085-9"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.16","DOI":"10.1016\/S0016-5085(97)70111-2"},{"key":"2025073013073529000_1.1.e000004.17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1053\/hupa.2000.8908","article-title":"Fundic gland polyps: do they arise as a by-product of hypergastrinemia in patients with Zollinger-Ellison syndrome?","volume":"31","author":"Declich","year":"2000","journal-title":"Hum Pathol"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.18","DOI":"10.1136\/gutjnl-2011-300348"},{"doi-asserted-by":"publisher","key":"2025073013073529000_1.1.e000004.19","DOI":"10.1136\/gut.51.5.742"},{"key":"2025073013073529000_1.1.e000004.20","first-page":"1721","article-title":"Sporadic fundic gland polyps: what happened before?","volume":"53","author":"Declich","year":"2004","journal-title":"Gut"}],"container-title":["BMJ Open Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjgast-2014-000004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T20:07:43Z","timestamp":1753906063000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopengastro.bmj.com\/lookup\/doi\/10.1136\/bmjgast-2014-000004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1136\/bmjgast-2014-000004"],"URL":"https:\/\/doi.org\/10.1136\/bmjgast-2014-000004","relation":{},"ISSN":["2054-4774"],"issn-type":[{"type":"electronic","value":"2054-4774"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}