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Many studies demonstrated that while hepatic macrophages promoted fibrosis through the recruitment of proinflammatory immune cells, and the secretion of proinflammatory cytokines and chemokines in the early stages, these also promoted the resolution of hepatic fibrosis through the secretion of matrix metalloproteinases in the late stages. This article will review the current role played by hepatic macrophages in liver fibrosis and the potential therapeutic targets that modulate hepatic macrophages.<\/jats:p>","DOI":"10.1136\/bmjgast-2016-000079","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T10:08:21Z","timestamp":1464170901000},"page":"e000079","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets"],"prefix":"10.1136","volume":"3","author":[{"given":"Hai","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People's Armed Police Force, Tianjin, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"You","sequence":"additional","affiliation":[{"name":"Liver Research Center, 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