{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:31:56Z","timestamp":1784723516284,"version":"3.55.0"},"reference-count":35,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Gastroenterol"],"accepted":{"date-parts":[[2023,2,9]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Poor bowel preparation is the leading cause of failed colonoscopies and increases costs significantly. Several, split preparation, 2 day regimens are available and recently, Plenvu, a low-volume preparation which can be given on 1\u2009day has been introduced.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Assess efficacy and tolerability of commonly used purgative regimens including Plenvu.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>In this service evaluation, patients undergoing screening colonoscopy at St Mark\u2019s Hospital, London (February 2020\u2013December 2021) were provided Plenvu (1 or 2\u2009days), Moviprep (2\u2009days) or Senna &amp; Citramag (2\u2009days).<\/jats:p>\n                  <jats:p>Boston Bowel Preparation Scale (BBPS) score, fluid volumes and procedure times were recorded. A patient experience questionnaire evaluated taste, volume acceptability, completion and side effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>563 patients were invited to participate and 553 included: 218 Moviprep 2\u2009days, 108 Senna &amp; Citramag 2\u2009days, 152 Plenvu 2\u2009days and 75 Plenvu 1\u2009day.<\/jats:p>\n                  <jats:p>BBPS scores were higher with Plenvu 1 and 2\u2009days vs Senna &amp; Citramag (p=0.003\u2009and 0.002, respectively) and vs Moviprep (p=0.003\u2009and 0.001, respectively). No other significant pairwise BBPS differences and no difference in preparation adequacy was seen between the groups.<\/jats:p>\n                  <jats:p>Patients rated taste as most pleasant with Senna &amp; Citramag and this achieved significance versus Plenvu 1\u2009day and 2\u2009days (p=0.002\u2009and p&lt;0.001, respectively) and versus Moviprep (p=0.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>BBPS score was higher for 1\u2009day and 2\u2009days Plenvu versus both Senna &amp; Citramag and Moviprep. Taste was not highly rated for Plenvu but it appears to offer effective cleansing even when given as a same day preparation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjgast-2022-001070","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T01:05:35Z","timestamp":1679879135000},"page":"e001070","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of bowel preparation regimens for colonoscopy including a novel low volume regimen (Plenvu): CLEANSE study"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-3545","authenticated-orcid":false,"given":"Ahmir","family":"Ahmad","sequence":"first","affiliation":[{"name":"Wolfson Unit for Endoscopy, St Mark's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Marshall","sequence":"additional","affiliation":[{"name":"Wolfson Unit for 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